Overexpression of hexokinase II increases insulinand exercise-stimulated muscle glucose uptake in vivo

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

1980 • 1,066 citations

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

1980 • 1,042 citations

Pancreatic Glucagon Secretion in Normal and Diabetic Subjects

1969 • 540 citations

Multiple Hexokinases of Rat Tissues

1966 • 483 citations

A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes

1976 • 417 citations

Mechanism of insulin action on glucose transport in the isolated rat adipose cell. Enhancement of the number of functional transport systems.

1978 • 330 citations

Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle

1993 • 281 citations

Glucose Transport Is Rate Limiting for Skeletal Muscle Glucose Metabolism in Normal and STZ-Induced Diabetic Rats

1988 • 208 citations

Enhanced Insulin Action Due to Targeted GLUT4 Overexpression Exclusively in Muscle

1996 • 191 citations

Hexokinase II mRNA and gene structure, regulation by insulin, and evolution.

1993 • 181 citations

Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice.

1995 • 168 citations

Predicting submaximal oxygen consumption during treadmill running in mice

1993 • 151 citations

Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle.

1993 • 119 citations

Glucose uptake and transport in contracting, perfused rat muscle with different pre‐contraction glycogen concentrations.

1990 • 113 citations

Improvement of Insulin Action in Diabetic Transgenic Mice Selectively Overexpressing GLUT4 in Skeletal Muscle

1996 • 110 citations

Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene.

1994 • 101 citations

Rat skeletal muscle hexokinase II mRNA and activity are increased by a single bout of acute exercise

1994 • 100 citations

Functional Organization of Mammalian Hexokinase II

1996 • 89 citations

No accumulation of glucose in human skeletal muscle during euglycemic hyperinsulinemia

1988 • 85 citations

Regulation of glucose utilization in human skeletal muscle during moderate dynamic exercise

1991 • 79 citations

Overexpression of Hexokinase II in Transgenic Mice

1996 • 76 citations

Sarcolemmal glucose transport and GLUT-4 translocation during exercise are diminished by endurance training

1998 • 75 citations

A novel¹³C NMR method to assess intracellular glucose concentration in muscle, in vivo

1998 • 62 citations

Expression of human GLUT4 in mice results in increased insulin action

1994 • 58 citations

Expression of an insulin-responsive glucose transporter (GLUT4) minigene in transgenic mice: effect of exercise and role in glucose homeostasis.

1995 • 54 citations

Limitations to exercise- and maximal insulin-stimulated muscle glucose uptake

1998 • 53 citations

Differential effects of GLUT-1 or GLUT-4 overexpression on insulin responsiveness in transgenic mice

1994 • 50 citations

Human Hexokinase II mRNA and Gene Structure

1995 • 46 citations

Progressive increase in glucose transport and GLUT-4 in human sarcolemmal vesicles during moderate exercise

1997 • 46 citations

Incorporation of [3-3H]Glucose and 2-[1-14C]Deoxyglucose Into Glycogen in Heart and Skeletal Muscle In Vivo: Implications for the Quantitation of Tissue Glucose Uptake

1997 • 38 citations

Analysis of insulin-stimulated skeletal muscle glucose uptake in conscious rat using isotopic glucose analogs

1998 • 30 citations

Incorporation of 2-deoxy-d-glucose into glycogen. Implications for measurement of tissue-specific glucose uptake and utilisation

1996 • 30 citations

Incorporation of 2-deoxy-d-glucose into glycogen

1968 • 29 citations

In vivo NMR evidence for moderate glucose accumulation in human skeletal muscle during hyperglycemia

1996 • 18 citations

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