Derangements of pyruvate dehydrogenase in circulating lymphocytes of NIDDM patients and their healthy offspring

Statistical Methods in Medical Research.

1972 • 4,731 citations

Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance

1979 • 4,730 citations

The insulin signaling system.

1994 • 1,733 citations

Early Metabolic Defects in Persons at Increased Risk for Non-Insulin-Dependent Diabetes Mellitus

1989 • 835 citations

Generation by Insulin of a Chemical Mediator That Controls Protein Phosphorylation and Dephosphorylation

1979 • 373 citations

The mammalian pyruvate dehydrogenase complex: Structure and regulation

1983 • 336 citations

Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus.

1992 • 301 citations

The Metabolic Profile of NIDDM Is Fully Established in Glucose-Tolerant Offspring of Two Mexican-American NIDDM Parents

1992 • 274 citations

Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: Effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion

1971 • 231 citations

Pyruvate Dehydrogenase Activation in Adipocyte Mitochondria by an Insulin-Generated Mediator from Muscle

1979 • 222 citations

Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus.

1990 • 204 citations

Active and Inactive Forms of Pyruvate Dehydrogenase in Rat Liver

1972 • 199 citations

Determination of coenzyme A and acetyl CoA in tissue extracts

1969 • 197 citations

Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: Evidence for generation of insulin's second messenger in a subcellular system

1980 • 172 citations

International federation of clinical chemistry

1996 • 159 citations

Second Messengers of Insulin Action

1990 • 148 citations

Impaired Activation of Glycogen Synthase in People at Increased Risk for Developing NIDDM

1992 • 139 citations

Does Mitogen-Activated-Protein Kinase have a Role in Insulin Action?. The Cases for and Against

1995 • 125 citations

Purification and properties of pyruvate dehydrogenase phosphatase from bovine heart and kidney

1982 • 115 citations

Intracellular Defects in Glucose Metabolism in Obese Patients With NIDDM

1992 • 110 citations

Does Mitogen‐Activated‐Protein Kinase have a Role in Insulin Action?

1995 • 107 citations

Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet

1976 • 105 citations

Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exercise

1976 • 104 citations

Insulin stimulation of pyruvate dehydrogenase in an isolated plasma membrane-mitochondrial mixture occurs by activation of pyruvate dehydrogenase phosphatase.

1980 • 95 citations

Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities.

1982 • 85 citations

Insulin stimulates the release from liver plasma membranes of a chemical modulator of pyruvate dehydrogenase

1981 • 74 citations

Studies on the Insulin Mediator: II. Separation of Two Antagonistic Biologically Active Materials from Fraction II

1980 • 64 citations

Incorporation of 32Pi into pyruvate dehydrogenase phosphate in mitochondria from control and insulin-treated adipose tissue

1976 • 63 citations

Insulin mediator stimulation of pyruvate dehydrogenase phosphatases

1992 • 45 citations

Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects

1986 • 40 citations

Lactate Production and Pyruvate Dehydrogenase Activity in Fat and Skeletal Muscle From Diabetic Rats

1992 • 36 citations

The insulinomimetic effects of the polar head group of an insulin-sensitive glycophospholipid on pyruvate dehydrogenase in both subcellular and whole cell assays

1988 • 36 citations

Insulin action on metabolism

1997 • 20 citations

Regulation of pyruvate dehydrogenase by insulin and polyamines within electropermeabilized fat-cells and isolated mitochondria

1992 • 19 citations

Estimation of normal ranges of clinical laboratory data

1986 • 19 citations

Provisional recommendation on the theory of reference values (1978)

1978 • 15 citations

Insulin resistance in obese subjects and newly diagnosed NIDDM patients and derangements of pyruvate dehydrogenase in their circulating lymphocytes

1997 • 14 citations

Insulin modulation of pyruvate dehydrogenase in human circulating lymphocytes

1988 • 13 citations

The International Federation of Clinical Chemistry, IFCC Section (1978) no. 2. International Federation of Clinical Chemistry provisional recommendation on the theory of reference values (1978). Part 1. The concept of reference values.

1979 • 9 citations

The insulin signal and its effects on the pyruvate dehydrogenase complex in cirulating lymphocytes of obese children

1992 • 9 citations

A signal for β-cell failure

1998 • 8 citations

Effect of sulfonylurea agents on pyruvate dehydrogenase activity in circulating lymphocytes from patients with non-insulin-dependent diabetes mellitus (NIDDM)

1994 • 8 citations

Effects of insulin on pyruvate dehydrogenase in circulating lymphocytes from normal and diabetic rats

1988 • 7 citations

Molecular effects of sulphonylurea agents in circulating lymphocytes of patients with non‐insulin‐dependent diabetes mellitus

1998 • 6 citations