Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo

An improved assay for nanomole amounts of inorganic phosphate

1979 • 2,157 citations

Pathogenesis of NIDDM: A Balanced Overview

1992 • 2,111 citations

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

1992 • 736 citations

Quantitation of Hepatic Glycogenolysis And Gluconeogenesis in Fasting Humans With ¹³ C NMR

1991 • 515 citations

Contributions of gluconeogenesis to glucose production in the fasted state.

1996 • 470 citations

Laboratory animals exhibiting obesity and diabetes syndromes

1977 • 417 citations

The Family of Glycogen Phosphorylases: Structure and Functio

1989 • 386 citations

Role of Liver in Pathophysiology of NIDDM

1992 • 209 citations

Enhanced muscle glucose metabolism after exercise in the rat: the two phases

1984 • 205 citations

The spectrin membrane skeleton of normal and abnormal human erythrocytes: a review

1983 • 195 citations

Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study.

1997 • 186 citations

The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans.

1996 • 150 citations

Potent inhibition of glycogen phosphorylase by a spirohydantoin of glucopyranose: First pyranose analogues of hydantocidin

1995 • 133 citations

Design of Inhibitors of Glycogen Phosphorylase: A Study of .alpha.- and .beta.-C-Glucosides and 1-Thio-.beta.-D-glucose Compounds

1994 • 120 citations

The regulation of glycogen phosphorylase alpha by nucleotide derivatives. Kinetic and x-ray crystallographic studies.

1978 • 119 citations

Synergistic regulation of phosphorylase a by glucose and caffeine.

1978 • 113 citations

Glucose analog inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes

1991 • 109 citations

Glucose production, recycling, and gluconeogenesis in normals and diabetics: a mass isotopomer [U-13C]glucose study

1996 • 107 citations

Glucose uptake and insulin sensitivity in rat muscle: changes during 3-96 weeks of age

1983 • 106 citations

Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene.

1994 • 101 citations

Kinetic mechanism of phosphorylase a. I. Initial velocity studies

1970 • 86 citations

Simultaneous synthesis and degradation of rat liver glycogen. An in vivo nuclear magnetic resonance spectroscopic study.

1990 • 78 citations

A New Technique for Isolating and Culturing Human Hepatocytes from Whole or Split Livers not Used for Transplantation

1994 • 71 citations

New Pharmacological Approaches to Therapy of NIDDM

1992 • 67 citations

Analysis of an allosteric binding site: the nucleoside inhibitor site of phosphorylase a

1982 • 51 citations

Regulation of the dephosphorylation of glycogen phosphorylase a and synthase b by glucose and caffeine in isolated hepatocytes

1981 • 42 citations

Specific Inhibition of Glycogen Phosphorylase by a Spirodiketopiperazine at the Anomeric position of Glucopyranose

1995 • 37 citations

An engineered liver glycogen phosphorylase with AMP allosteric activation

1991 • 32 citations

Specific inhibition of glycogen phosphorylase by a spirodiketopiperazine at the anomeric position of glucopyranose

1995 • 31 citations

Effects of C-1-substituted glucose analogue on the activation states of glycogen synthase and glycogen phosphorylase in rat hepatocytes

1995 • 31 citations

Effects of Novel Analogues of D‐Glucose on Glycogen Phosphorylase Activities in Crude Extracts of Liver and Skeletal Muscle

1995 • 31 citations

[Enzymatic studies of hepatic fragments; application to the classification of glycogenoses].

1959 • 30 citations

Insulin and glucose suppress hepatic glycogenolysis by distinct enzymatic mechanisms

1993 • 24 citations

Synthesis and crystallographic analysis of two rhizopuspepsin inhibitor complexes

1992 • 23 citations

Mass spectra of labelled methylquinolines

1970 • 21 citations

2 Hepatic glucose metabolism and insulin resistance in NIDDM and obesity

1993 • 21 citations

The effect of caffeine and caffeine analogs on rat liver phosphorylase a activity.

1997 • 21 citations

Glycogen: its mode of formation and contribution to hepatic glucose output in postabsorptive humans

1994 • 17 citations

The nucleotide sequence of rat liver glycogen phosphorylase cDNA

1992 • 16 citations

Purification of glycogen phosphorylase isozymes by metal-affinity chromatography

1992 • 16 citations

Actions of the novel antidiabetic agent englitazone in rat hepatocytes

1993 • 13 citations

Role of liver and muscle in type II diabetes.

1992 • 4 citations

Role of liver and muscle in type II diabetes.

1992 • 3 citations

Effects of Novel Analogues of D-Glucose on Glycogen Phosphorylase Activities in Crude Extracts of Liver and Skeletal Muscle

1995 • 2 citations

Deleted Work

1955 • 0 citations