Hexokinase II-deficient Mice

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Pathogenesis of NIDDM: A Balanced Overview

1992 • 2,111 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Insulin Resistance — Mechanisms, Syndromes, and Implications

1991 • 788 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Gene Targeting: A Practical Approach

1994 • 592 citations

Gene targeting: a practical approach.

1993 • 585 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

Multiple Hexokinases of Rat Tissues

1966 • 483 citations

Hexokinases

2006 • 353 citations

Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene

1992 • 319 citations

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.

1996 • 287 citations

Non-injection methods for the production of embryonic stem cell-embryo chimaeras

1993 • 286 citations

Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis

1995 • 277 citations

Saphenous vein puncture for blood sampling of the mouse, rat, hamster, gerbil, guineapig, ferret and mink

1998 • 260 citations

Pancreatic β-Cell-specific Targeted Disruption of Glucokinase Gene

1995 • 235 citations

The New Elements of Insulin Signaling: Insulin Receptor Substrate-1 and Proteins With SH2 Domains

1993 • 221 citations

Glucose Transport Is Rate Limiting for Skeletal Muscle Glucose Metabolism in Normal and STZ-Induced Diabetic Rats

1988 • 208 citations

Hexokinase II mRNA and gene structure, regulation by insulin, and evolution.

1993 • 181 citations

Lessons Learned From Molecular Biology of Insulin-Gene Mutations

1990 • 154 citations

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

1997 • 144 citations

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

1998 • 143 citations

Animal Model for Maturity-onset Diabetes of the Young Generated by Disruption of the Mouse Glucokinase Gene

1995 • 135 citations

Molecular cloning of glucokinase cDNA. Developmental and dietary regulation of glucokinase mRNA in rat liver.

1987 • 133 citations

Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.

1998 • 121 citations

Purification and Properties of Pig‐Heart Hexokinase

1973 • 115 citations

Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects.

1998 • 94 citations

The comparative isozymology of vertebrate hexokinases

1982 • 90 citations

Overexpression of Hexokinase II in Transgenic Mice

1996 • 76 citations

Amino Acid Substitutions in Hexokinase II Among Patients With NIDDM

1995 • 64 citations

Cell cycle arrest in the G2 phase induced by phorbol ester and diacylglycerol in vascular endothelial cells

1996 • 56 citations

Six Mutations in the Glucokinase Gene Identified in MODY by Using a Nonradioactive Sensitive Screening Technique

1994 • 50 citations

Death of mouse embryos that lack a functional gene for glucose phosphate isomerase

1990 • 34 citations

Developmental expression of hexokinase 1 in the rat

1992 • 33 citations

Phenotype of transgenic mice overexpressing GLUT4 and hexokinase II in muscle

1997 • 29 citations

Glucose-6-phosphate isomerase deficiency associated with nonspherocytic hemolytic anemia in the mouse: an animal model for the human disease

1993 • 27 citations

Developmental expression of hexokinase 1 and 3 in rats

1997 • 21 citations

Nuclear Magnetic Resonance Studies of Muscle and Applications to Exercise and Diabetes

1996 • 17 citations

Genetic evidence that glycolysis is necessary for gastrulation in the mouse

1996 • 17 citations

A glucosephosphate isomerase (GPI) null mutation in Mus musculus: evidence that anaerobic glycolysis is the predominant energy delivering pathway in early post-implantation embryos

1992 • 15 citations

Distinguishing the type I and type II isozymes of hexokinase: the need for a reexamination of past practice.

1998 • 14 citations