Mechanism by which metformin reduces glucose production in type 2 diabetes.

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

1988 • 2,463 citations

Metformin

1996 • 1,637 citations

Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes Mellitus

1995 • 1,328 citations

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

Metabolic Effects of Metformin in Non-Insulin-Dependent Diabetes Mellitus

1995 • 1,135 citations

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

1998 • 798 citations

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

1992 • 736 citations

Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.

1981 • 628 citations

Quantitation of Hepatic Glycogenolysis And Gluconeogenesis in Fasting Humans With ¹³ C NMR

1991 • 515 citations

Efficacy of Metformin in Type II Diabetes

1997 • 497 citations

Contributions of gluconeogenesis to glucose production in the fasted state.

1996 • 470 citations

Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.

1996 • 410 citations

Mechanism of Metformin Action in Obese and Lean Noninsulin-Dependent Diabetic Subjects*

1991 • 400 citations

A microfluorometric method for the determination of free fatty acids in plasma

1983 • 336 citations

Metformin: A review of its metabolic effects

1998 • 311 citations

Metabolic Effects of Troglitazone Monotherapy in Type 2 Diabetes Mellitus

1998 • 293 citations

Effect of Metformin on Carbohydrate and Lipoprotein Metabolism in NIDDM Patients

1990 • 263 citations

Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans.

1998 • 231 citations

Acute Antihyperglycemic Mechanisms of Metformin in NIDDM: Evidence for Suppression of Lipid Oxidation and Hepatic Glucose Production

1994 • 217 citations

Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus.

1975 • 215 citations

Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state.

1995 • 178 citations

The Role of Fatty Acids in Mediating the Effects of Peripheral Insulin on Hepatic Glucose Production in the Conscious Dog

1997 • 162 citations

The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans.

1996 • 150 citations

Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes

1993 • 149 citations

Central Role of the Adipocyte in Insulin Resistance

1998 • 122 citations

Relationship Between Hepatic Glucose Production and Fasting Plasma Glucose Concentration in Patients With NIDDM

1994 • 107 citations

Liver glycogen turnover in fed and fasted humans

1994 • 106 citations

Effects of Metformin on Lactate Uptake and Gluconeogenesis in the Perfused Rat Liver

1997 • 105 citations

Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis

1999 • 93 citations

In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans

1991 • 86 citations

Combined metformin-sulfonylurea treatment of patients with noninsulin-dependent diabetes in fair to poor glycemic control.

1992 • 85 citations

Limitations of the Mass Isotopomer Distribution Analysis of Glucose to Study Gluconeogenesis

1995 • 84 citations

Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans.

1990 • 70 citations

Validation of ¹³C NMR measurements of liver glycogen in vivo

1994 • 68 citations

Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.

1999 • 63 citations

Human serum cholesterol synthesis measured with the deuterium label.

1966 • 54 citations

A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo

1999 • 49 citations

A limitation in the use of mass isotopomer distributions to measure gluconeogenesis in fasting humans

1995 • 42 citations

Limitations of the Mass Isotopomer Distribution Analysis of Glucose to Study Gluconeogenesis

1998 • 27 citations

A micromethod for the measurement of deuterium bound to carbon‐6 of glucose to quantify gluconeogenesis in vivo

1995 • 24 citations

Direct analysis of 18O in glucose by mass spectrometry☆

1973 • 13 citations

Deleted Work

1955 • 0 citations