Overexpression of Hexokinase II in Transgenic Mice

A Flexible System of Enzymatic Analysis

1972 • 4,133 citations

A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose

1968 • 1,213 citations

Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle.

1994 • 425 citations

31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.

1992 • 324 citations

Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus.

1995 • 316 citations

Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle

1993 • 281 citations

Kinetics of glucose disposal in whole body and across the forearm in man.

1987 • 268 citations

Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats.

1990 • 258 citations

Glucose Transport Is Rate Limiting for Skeletal Muscle Glucose Metabolism in Normal and STZ-Induced Diabetic Rats

1988 • 208 citations

Muscle Creatine Kinase Sequence Elements Regulating Skeletal and Cardiac Muscle Expression in Transgenic Mice

1989 • 204 citations

Hexokinase II mRNA and gene structure, regulation by insulin, and evolution.

1993 • 181 citations

Multiple Forms of Hexokinase

1970 • 173 citations

Skeletal Muscle Glucose Transport and Metabolism Are Enhanced in Transgenic Mice Overexpressing the Glut4 Glucose Transporter

1995 • 166 citations

The multiple forms of mammalian hexokinase and their significance to the action of insulin

1967 • 163 citations

Glucose Metabolism in Rat Skeletal Muscle at Rest: Effect of Starvation, Diabetes, Ketone Bodies and Free Fatty Acids

1974 • 129 citations

Metabolite changes in individual rat muscle fibers during stimulation

1982 • 101 citations

Glucose transport activity in skeletal muscles from transgenic mice overexpressing GLUT1. Increased basal transport is associated with a defective response to diverse stimuli that activate GLUT4

1994 • 96 citations

The Effects of Hyperinsulinemia and Hyperglycemia on GLUT4 and Hexokinase II mRNA and Protein in Rat Skeletal Muscle and Adipose Tissue

1993 • 91 citations

Acute Hyperglycemia Provides an Insulin-Independent Inducer for GLUT4 Translocation in C2C12 Myotubes and Rat Skeletal Muscle

1995 • 79 citations

Glucose transporters in single skeletal muscle fibers. Relationship to hexokinase and regulation by contractile activity.

1994 • 72 citations

Evidence for functional hexokinase compartmentation in rat skeletal muscle mitochondria.

1984 • 71 citations

Kinetics, Mechanism, and Regulation of Rat Skeletal Muscle Hexokinase

1974 • 66 citations

Skeletal Muscle Glucose Transport and Metabolism Are Enhanced in Transgenic Mice Overexpressing the Glut4 Glucose Transporter.

1995 • 60 citations

Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice.

1994 • 57 citations

Reduced Expression of Hexokinase II in Insulin-Resistant Diabetes

1995 • 55 citations

Glucose transport and GLUT4 protein distribution in skeletal muscle of GLUT4 transgenic mice

1996 • 50 citations

Changes in free and bound forms and total amount of hexokinase isozyme II of rat muscle in response to contractile activity

1990 • 47 citations

Human Hexokinase II mRNA and Gene Structure

1995 • 46 citations

Loss of glucose-induced insulin secretion and GLUT2 expression in transplanted β-cells

1995 • 34 citations

Multiple forms of glucose-adenosine triphosphate phosphotransferase in rat mammary gland

1967 • 27 citations

Muscle-Specific Expression of Human Insulin Receptor in Transgenic Mice

1993 • 16 citations