Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

2002 • 1,540 citations

Mechanism of free fatty acid-induced insulin resistance in humans.

1996 • 1,507 citations

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

2002 • 1,345 citations

Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

1999 • 1,300 citations

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study

1999 • 1,267 citations

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

1999 • 1,256 citations

Pathophysiology of insulin resistance in human disease

1995 • 1,239 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Fat Accumulation in the Liver Is Associated with Defects in Insulin Suppression of Glucose Production and Serum Free Fatty Acids Independent of Obesity in Normal Men

2002 • 1,057 citations

Mechanisms of fatty acid-induced inhibition of glucose uptake.

1994 • 1,049 citations

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

1999 • 891 citations

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

2001 • 728 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 • 694 citations

Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo

1999 • 694 citations

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 • 588 citations

Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats

1991 • 586 citations

Characterization of the insulin resistance of aging.

1983 • 395 citations

SEQUENTIAL CHANGES IN SERUM INSULIN CONCENTRATION DURING DEVELOPMENT OF NON-INSULIN-DEPENDENT DIABETES

1989 • 276 citations

The Economic Costs of Non—Insulin-Dependent Diabetes Mellitus

1989 • 191 citations

Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle

2001 • 149 citations

Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle

2001 • 142 citations

13C/31P NMR studies on the mechanism of insulin resistance in obesity.

1998 • 114 citations

Effect of increased free fatty acid supply on glucose metabolism and skeletal muscle glycogen synthase activity in normal man

1992 • 75 citations

Development of diabetes in Japanese subjects with impaired glucose tolerance: A seven year follow-up study

1982 • 55 citations

[Physiopathology of mitochondria. From Luft's disease to aging and diabetes].

1993 • 5 citations

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