Impaired Insulin-Stimulated Expression of the Glycogen Synthase Gene in Skeletal Muscle of Type 2 Diabetic Patients Is Acquired Rather Than Inherited1

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Pathogenesis of NIDDM: A Balanced Overview

1992 • 2,111 citations

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

1997 • 1,647 citations

Early Metabolic Defects in Persons at Increased Risk for Non-Insulin-Dependent Diabetes Mellitus

1989 • 835 citations

REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE EXPRESSION

1997 • 726 citations

Regulation of gene expression by insulin

1996 • 543 citations

Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man.

1987 • 519 citations

Monitoring mRNA Expression by Polymerase Chain Reaction: The "Primer-Dropping" Method

1994 • 410 citations

Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus.

1992 • 301 citations

Role of Insulin in the Regulation of Protein Synthesis

1980 • 234 citations

Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus.

1995 • 210 citations

Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus.

1991 • 154 citations

Impaired Activation of Glycogen Synthase in People at Increased Risk for Developing NIDDM

1992 • 139 citations

Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms.

1996 • 132 citations

Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle.

1996 • 124 citations

Analysis of the Signaling Pathway Involved in the Regulation of Hexokinase II Gene Transcription by Insulin

1996 • 122 citations

Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus.

1993 • 98 citations

Function of the Human Insulin Promoter in Primary Cultured Islet Cells

1996 • 82 citations

Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with Type 2 (non-insulin-dependent) diabetes mellitus

1992 • 68 citations

Defective regulation of phosphatidylinositol-3-kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients

1999 • 65 citations

Impaired Expression of Glycogen Synthase mRNA in Skeletal Muscle of NIDDM Patients

1991 • 63 citations

Insulin-regulated mitochondrial gene expression is associated with glucose flux in human skeletal muscle.

1999 • 62 citations

Acquired Defects of Glycogen Synthase Activity in Cultured Human Skeletal Muscle Cells: Influence of High Glucose and Insulin Levels

1996 • 59 citations

Association of the glycogen synthase locus on 19q13 with NIDDM in Pima Indians

1996 • 52 citations

Isolation and Characterization of the Human Muscle Glycogen Synthase Gene

1995 • 38 citations

Intracellular Glucose and Fat Metabolism in Identical Twins Discordant for Non-insulin-dependent Diabetes Mellitus (NIDDM): Acquired Versus Genetic Metabolic Defects?

1996 • 29 citations

Regulation of Glycogen Synthase Activity in Cultured Skeletal Muscle Cells From Subjects With Type II Diabetes: Role of Chronic Hyperinsulinemia and Hyperglycemia

1997 • 26 citations

Expression of naturally occurring variants in the muscle glycogen synthase gene.

1999 • 19 citations

Long-term effects of insulin on the enzyme activity and messenger RNA of glycogen synthase in rat hepatoma H4 cells: An effect of insulin on glycogen synthase mRNA stability

1991 • 16 citations

Increased concentrations of glycogen synthase protein in skeletal muscle of patients with NIDDM

1995 • 13 citations

Nuclear Magnetic Resonance Studies of Glucose Metabolism in Non-Insulin-Dependent Diabetes Mellitus Subjects

1996 • 13 citations

Insulin Stimulates Protein Synthesis of Glycogen Synthase in Rat Hepatoma H4 Cells Associated with Acceleration of Translation Rate.

1996 • 5 citations

Sequence of the 5'-flanking region of the gene encoding human muscle glycogen synthase

1994 • 3 citations