Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.

Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

1972 • 31,801 citations

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

1979 • 7,240 citations

Pathogenesis of NIDDM: A Balanced Overview

1992 • 2,111 citations

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

Metabolic Effects of Metformin in Non-Insulin-Dependent Diabetes Mellitus

1995 • 1,135 citations

Lipid Research Clinics Program

1984 • 837 citations

Measurement of Size and Turnover Rate of Body Glucose Pool by the Isotope Dilution Method

1956 • 827 citations

Biguanides and NIDDM

1992 • 601 citations

ON THE HORMONAL REGULATION OF CARBOHYDRATE METABOLISM; STUDIES WITH C14 GLUCOSE.

1963 • 540 citations

The Minnesota impedance cardiograph- theory and applications.

1974 • 403 citations

Mechanism of Metformin Action in Obese and Lean Noninsulin-Dependent Diabetic Subjects*

1991 • 400 citations

Predominant Role of Gluconeogenesis in Increased Hepatic Glucose Production in NIDDM

1989 • 387 citations

Indirect calorimetry: methodological and interpretative problems

1990 • 370 citations

A microfluorometric method for the determination of free fatty acids in plasma

1983 • 336 citations

Relative effects of calorie restriction and weight loss in noninsulin- dependent diabetes mellitus

1993 • 300 citations

The disposal of an oral glucose load in patients with non-insulin-dependent diabetes

1988 • 296 citations

SEQUENTIAL CHANGES IN SERUM INSULIN CONCENTRATION DURING DEVELOPMENT OF NON-INSULIN-DEPENDENT DIABETES

1989 • 276 citations

Glycemic Effects of Intensive Caloric Restriction and Isocaloric Refeeding in Noninsulin-Dependent Diabetes Mellitus*

1985 • 249 citations

Glucoregulatory responses in normal and diabetic dogs recorded by a new tracer method

1971 • 244 citations

Acute Antihyperglycemic Mechanisms of Metformin in NIDDM: Evidence for Suppression of Lipid Oxidation and Hepatic Glucose Production

1994 • 217 citations

Metformin Improves Glucose, Lipid Metabolism, and Reduces Blood Pressure in Hypertensive, Obese Women

1993 • 207 citations

Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism.

1990 • 199 citations

Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus.

1992 • 192 citations

Mechanism of Metformin Action in Non-Insulin-Dependent Diabetes

1987 • 184 citations

Metformin: a review of its pharmacological properties and therapeutic use.

1979 • 172 citations

Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes

1993 • 149 citations

Contribution of liver and skeletal muscle to alanine and lactate metabolism in humans

1990 • 143 citations

The impact of metformin therapy on hepatic glucose production and skeletal muscle glycogen synthase activity in overweight type II diabetic patients

1993 • 142 citations

Lactate Turnover and Gluconeogenesis in Normal and Obese Humans: Effect of Starvation

1970 • 128 citations

Phenformin-Associated Lactic Acidosis: Pathogenesis and Treatment

1977 • 117 citations

Metformin improves peripheral but not hepatic insulin action in obese patients with type II diabetes

1989 • 116 citations

Inhibition of hepatic gluconeogenesis by metformin

1988 • 108 citations

Effect of Metformin on Insulin-Stimulated Glucose Turnover and Insulin Binding to Receptors in Type II Diabetes

1987 • 105 citations

Combined metformin-sulfonylurea treatment of patients with noninsulin-dependent diabetes in fair to poor glycemic control.

1992 • 85 citations

Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms of hyperglycemia in obese non-insulin-dependent diabetic subjects

1988 • 84 citations

Cardiac output measured by impedance cardiography during maximal exercise tests

1985 • 82 citations

Lipolysis and gluconeogenesis from glycerol are increased in patients with noninsulin-dependent diabetes mellitus.

1992 • 81 citations

Turnover and precursor-product relationships of nonlipid metabolites.

1983 • 79 citations

Determination of Lactate Kinetics in the Human Analysis of Data From Single Injection vs. Continuous Infusion Methods

1972 • 75 citations

Sample site selection for tracer studies applying a unidirectional circulatory approach

1987 • 63 citations

Metabolic effects of metformin addition to chronic glibenclamide treatment in type 2 diabetes.

1994 • 37 citations

Estimating Gluconeogenic Rates in NIDDM

1993 • 29 citations