Regulation of the citric acid cycle in mammalian systems

Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle

1974 • 1,252 citations

Regulation of Metabolic Processes in Mitochondria

1967 • 1,182 citations

Keilin's Respiratory Chain Concept and Its Chemiosmotic Consequences

1979 • 727 citations

The Influence of Respiration and ATP Hydrolysis on the Proton‐Electrochemical Gradient across the Inner Membrane of Rat‐Liver Mitochondria as Determined by Ion Distribution

1974 • 707 citations

Metabolite Transport in Mitochondria

1979 • 618 citations

Regulation in Metabolism

1974 • 607 citations

Myocardial utilization of carbohydrate and lipids

1972 • 505 citations

Disturbances in Lipid and Lipoprotein Metabolism

1978 • 482 citations

Coenzyme A and carnitine distribution in normal and ischemic hearts.

1978 • 481 citations

Hormonal effects on calcium homeostasis in isolated hepatocytes.

1980 • 441 citations

Calcium transients in aequorin-injected frog cardiac muscle

1978 • 441 citations

Vectorial Chemistry and the Molecular Mechanics of Chemiosmotic Coupling: Power Transmission by Proticity

1976 • 431 citations

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1979 • 431 citations

Calcium and Cardiac Excitation-Contraction Coupling

1979 • 425 citations

The Regulation of Intracellular Calcium

1978 • 415 citations

Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide

1976 • 399 citations

The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria

1978 • 380 citations

Molecular and physiological aspects of adenine nucleotide trasport in mitochondria

1976 • 373 citations

Regulation of Ca ²⁺ release from mitochondria by the oxidation-reduction state of pyridine nucleotides

1978 • 364 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

Regulation of Hepatic Metabolism

1976 • 314 citations

Control of maximum rates of glycolysis in rat cardiac muscle.

1979 • 311 citations

The Role of Citric Acid in Intermediate Metabolism in Animal Tissues

1968 • 292 citations

Proton-pumping cytochrome c oxidase

1979 • 280 citations

MITOCHONDRIA AND THE CONTROL OF INTRACELLULAR CALCIUM

1978 • 278 citations

Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart

1970 • 270 citations

RECENT ADVANCES IN STUDIES ON CARDIAC STRUCTURE AND METABOLISM

1976 • 261 citations

Use of Isolated Liver Cells and Kidney Tubules in Metabolic Studies

1976 • 252 citations

Calcium uptake and membrane potential in mitochondria

1974 • 247 citations

Microenvironments and Metabolic Compartmentation

1979 • 236 citations

Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: Effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion

1971 • 231 citations

Control of Citric Acid Cycle Activity in Rat Heart Mitochondria

1970 • 229 citations

Regulation of heart muscle pyruvate dehydrogenase kinase

1974 • 227 citations

The metabolic significance of anion transport in mitochondria

1974 • 225 citations

Regulation of Fatty Acid Utilization in Isolated Perfused Rat Hearts

1973 • 222 citations

The phosphorylation potential generated by respiring mitochondria

1973 • 212 citations

Evidence for more than one C²⁺ion transport mechanism in mitochondria

1976 • 211 citations

Relation between the Gradient of the ATP/ADP Ratio and the Membrane Potential across the Mitochondrial Membrane

1977 • 210 citations

Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats

1977 • 208 citations

Studies on alpha-adrenergic activation of hepatic glucose output. The role of mitochondrial calcium release in alpha-adrenergic activation of phosphorylase in perfused rat liver.

1979 • 201 citations

The calcium cycle of mitochondria

1979 • 197 citations

Regulated release of Ca2+ from respiring mitochondria by Ca2+/2H+ antiport.

1979 • 182 citations

Feedback Interactions in the Control of Citric Acid Cycle Activity in Rat Heart Mitochondria

1972 • 179 citations

Regulation of pyruvate metabolism in mammalian tissues.

1979 • 166 citations

Non-equilibrium thermodynamics of energy conversion in bioenergetics

1979 • 162 citations

Control of Energy Metabolism

1976 • 160 citations

Regulation of Glutamate Metabolism and Interactions with the Citric Acid Cycle in Rat Heart Mitochondria

1973 • 158 citations

Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase

1974 • 157 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Properties of the Ca2+-sensitive dehydrogenases within intact uncoupled mitochondria from the white and brown adipose tissue of the rat

1980 • 157 citations

Control of mitochondrial respiration: A quantitative evaluation of the roles of cytochrome c and oxygen

1977 • 150 citations

Effect of nicotinamide adenine dinucleotide on the membrane-associated reduced nicotinamide adenine dinucleotide oxidase of Mycobacterium phlei.

1975 • 145 citations

Citric Acid Cycle: Control and Compartmentation

1969 • 135 citations

Mitochondrial-Cytosolic Interactions in Perfused Rat Heart

1973 • 134 citations

Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria

1978 • 130 citations

Evidence for mitochondrial localization of the hormone-responsive pool of Ca2+ in isolated hepatocytes.

1979 • 128 citations

Regulation of Mitochondrial α-Ketoglutarate Metabolism by Product Inhibition at α-Ketoglutarate Dehydrogenase

1974 • 123 citations

Mitochondrial pyruvate transport and its hormonal regulation

1980 • 119 citations

Respiratory control in isolated perfused rat heart. Role of the equilibrium relations between the mitochondrial electron carriers and the adenylate system

1975 • 118 citations

Some Kinetic Properties of Pig-Heart Oxoglutarate Dehydrogenase that Provide a Basis for Metabolic Control of the Enzyme Activity and also a Stoicheiometric Assay for Coenzyme A in Tissue Extracts

1964 • 117 citations

Carboxylation and decarboxylation reactions. Anaplerotic flux and removal of citrate cycle intermediates in skeletal muscle.

1979 • 115 citations

Mitochondrial Function in the Heart

1979 • 114 citations

Calcium Transients During Excitation-Contraction Coupling in Mammalian Heart: Aequorin Signals of Canine Purkinje Fibers

1980 • 106 citations

Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet

1976 • 105 citations

Regulation of Pyruvate Dehydrogenase in Rat Liver Mitochondria by Phosphorylation-Dephosphorylation

1974 • 104 citations

Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exercise

1976 • 104 citations

Inhibition of citrate synthase by succinyl‐CoA and other metabolites

1971 • 99 citations

Cell Compartmentation and Metabolic Channeling

1981 • 98 citations

Anion translocators in rat‐heart mitochondria

1971 • 95 citations

Microenvironments and metabolic compartmentation

1978 • 94 citations

Rat Liver Pyruvate Carboxylase

1971 • 93 citations

CALCIUM BUFFERING IN SQUID AXONS

1978 • 93 citations

The steady state concentrations of coenzyme A-SH and coenzyme A thioester, citrate, and isocitrate during tricarboxylate cycle oxidations in rabbit heart mitochondria.

1975 • 86 citations

Electrical imbalance of adenine nucleotide transport across the mitochondrial membrane.

1978 • 85 citations

Regulation of mitochondrial pyruvate carboxylation and gluconeogenesis in rat hepatocytes via an alpha-adrenergic, adenosine 3‘:5‘-monophosphate-independent mechanism.

1979 • 85 citations

Calcium transients in mammalian muscles

1980 • 85 citations

Enhanced activity of pyruvate dehydrogenase kinase in rat heart mitochondria in alloxan‐diabetes or starvation

1978 • 85 citations

Diphosphopyridine Nucleotide-linked Isocitrate Dehydrogenase from Bovine Heart

1970 • 84 citations

Mitochondrial and Cytosolic NADPH Systems and Isocitrate Dehydrogenase Indicator Metabolites during Ureogenesis from Ammonia in Isolated Rat Hepatocytes

1977 • 83 citations

Relationship between Oxygen Uptake of Perifused Rat-Liver Cells and the Cytosolic Phosphorylation State Calculated from Indicator Metabolites and a Redetermined Equilibrium Constant

1978 • 81 citations

DPN-Linked Isocitrate Dehydrogenase of Animal Tissues* *The unpublished experimental work from this laboratory presented here and the preparation of this article have been assisted by a grant from the National Institute of Arthritis and Metabolic Diseases (AM 10501), United States Public Health Service.

1970 • 76 citations

Na⁺ releases Ca²⁺ from liver, kidney and lung mitochondria

1980 • 74 citations

Permeability of isolated mitochondria to oxaloacetate

1973 • 72 citations

Active and inactive forms of pyruvatedehydrogenase in skeletal muscle as related to the metabolic and functional state of the muscle cell

1975 • 71 citations

A continuous recording technique for the measurement of carbon dioxide, and its application to mitochondrial oxidation and decarboxylation reactions

1967 • 71 citations

Use of isolated liver cells and kidney tubules in metabolic studies

1977 • 71 citations

Ketogenesis in isolated rat liver mitochondria I. Relationships with the citric acid cycle and with the mitochondrial energy state

1972 • 71 citations

Kinetic Studies of Citrate Synthase from Rat Kidney and Rat Brain

1973 • 63 citations

Drug Oxidations Dependent on Cytochrome P‐450 in Isolated Hepatocytes

1977 • 56 citations

Homeostatic regulation of cellular energy metabolism

1978 • 54 citations

Activation of pyruvate dehydrogenase in the perfused rat liver by vasopressin

1978 • 54 citations

METABOLIC CONTROL IN THE PERFUSED RAT HEART**Supported by U. S. Public Health Service Grant No. 12202-01.

1965 • 53 citations

Action of Magnesium Ion on Diphosphopyridine Nucleotide-linked Isocitrate Dehydrogenase from Bovine Heart

1974 • 51 citations

IS THERE AN ORGANIZATION OF KREBS CYCLE ENZYMES IN THE MITOCHONDRIAL MATRIX?

1972 • 48 citations

Sodium-induced calcium release from mitochondria in brown adipose tissue.

1979 • 48 citations

Regulation by calcium ions of pyruvate carboxylation, pyruvate transport, and adenine nucleotide transport in isolated rat liver mitochondria.

1977 • 48 citations

Physicochemical Properties of the Diphosphopyridine Nucleotide-specific Isocitrate Dehydrogenase of Pig Heart

1974 • 46 citations

Conversion of inactive (phosphorylated) pyruvate dehydrogenase complex into active complex by the phosphate reaction in heart mitochondria is inhibited by alloxan-diabetes or starvation in the rat

1978 • 46 citations

Some aspects of the kinetics of rat liver pyruvate carboxylase

1970 • 44 citations

The transport of oxaloacetate in isolated mitochondria

1977 • 44 citations

The control of isocitrate oxidation by rat liver mitochondria

1969 • 43 citations

Alanine as a gluconeogenic carrier

1979 • 38 citations

Effects of calcium ions and adenosine diphosphate on the activities of NAD+-linked isocitrate dehydrogenase from the radular muscles of the whelk and flight muscles of insects

1976 • 38 citations

Mechanisms for the oxidative decarboxylation of isocitrate: Implications for control

1975 • 38 citations

The control of tricarboxylate-cycle oxidations in blowfly flight muscle. The steady-state concentrations of citrate, isocitrate 2-oxoglutarate and malate in flight muscle and isolated mitochondria

1975 • 33 citations

Inhibition Studies of Rat Citrate Synthase

1973 • 31 citations

Regulation of Citrate Synthesis in Isolated Rat Liver Mitochondria

1971 • 29 citations

Role of multi‐site phosphorylation in regulation of pig heart pyruvate dehydrogenase phosphatase

1979 • 27 citations

Effects of glucagon and Na+ on the control of extramitochondrial free Ca2+ concentration by mitochondria from liver and heart

1980 • 27 citations

Pyruvate Dehydrogenase Activation after an Increase in Cardiac Output

1976 • 25 citations

MEASUREMENT OF CALCIUM ION CONCENTRATIONS WITH PHOTOPROTEINS

1978 • 25 citations

Pyruvate dehydrogenase complex — meticulous regulator of glucose disposal in animals

1978 • 24 citations

Regulation of carbamoyl-phosphate synthase (ammonia) in liver in relation to urea cycle activity

1979 • 22 citations

FEEDBACK CONTROL OF THE CITRIC ACID CYCLE

1972 • 21 citations

The Inhibition of Isocitrate Oxidation by Palmitoyl‐<scp>l</scp>‐carnitine and Palmitoyl‐CoA in Rat Liver Mitochondria

1976 • 21 citations

Control of Phosphoenolpyruvate Synthesis by Substrate Level Phosphorylation in Guinea Pig Liver Mitochondria

1973 • 17 citations

The regulation of metabolism

1956 • 17 citations

Energy-linked regulation of the citric acid cycle and the pool size of the cycle intermediates in the isolated perfused rat heart

1977 • 14 citations

Citric Acid Cycle. Control and Compartmentation. Herausgeg. von J. M. Lowenstein. Marcel Dekker, Inc., New York‐London 1969. 1. Aufl., XXI, 366 S., zahlr. Abb., $ 17.75

1970 • 13 citations

Fatty acid synthesis and Krebs' cycle activity in heart mitochondria

1973 • 8 citations

Cardiovascular System

1980 • 6 citations

Ethanol Metabolism in Perfused Liver and Isolated Hepatocytes with Associated Methodologies

1979 • 6 citations

CPRRELATION OF ISOMETRIC TENSION AND REDOX STATE IN PERFUSED RABBIT INTERVENTRICULAR SEPTUM

1978 • 5 citations