TGF-β and cancer

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Tamoxifen for early breast cancer: an overview of the randomised trials

1998 • 4,082 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)

1993 • 755 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

Tumor-suppressive pathways in pancreatic carcinoma.

1997 • 689 citations

DPC4 gene in various tumor types.

1996 • 680 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival

1993 • 518 citations

Latent transforming growth factor-β: Structural features and mechanisms of activation

1997 • 511 citations

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1998 • 494 citations

A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells

1996 • 479 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer

1996 • 451 citations

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.

1995 • 445 citations

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.

1994 • 431 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

TGF-β receptor signaling

1997 • 417 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1

1995 • 413 citations

Tumor suppressor activity of the TGF-β pathway in human cancers

1996 • 412 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

1993 • 402 citations

Comparison of Low-Dose Isotretinoin with Beta Carotene to Prevent Oral Carcinogenesis

1993 • 402 citations

Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.

1990 • 398 citations

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.

1999 • 395 citations

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15

1997 • 378 citations

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

1993 • 356 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Induction of transforming growth factor beta 1 in human breast cancer in vivo following tamoxifen treatment.

1992 • 344 citations

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.

1996 • 341 citations

Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells

1995 • 340 citations

Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

1989 • 333 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells

1994 • 325 citations

Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts

1990 • 324 citations

The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

1996 • 323 citations

Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency

1998 • 319 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

Mad-related genes in the human

1996 • 308 citations

Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells.

1997 • 295 citations

Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

1995 • 292 citations

Frequency of Smad gene mutations in human cancers.

1997 • 289 citations

Transforming growth factors from neoplastic and nonneoplastic tissues.

1983 • 288 citations

High levels of transforming growth factor beta 1 in patients with colorectal cancer: Association with disease progression

1996 • 285 citations

Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.

1998 • 284 citations

Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

1994 • 274 citations

Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

1991 • 266 citations

Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis

1998 • 263 citations

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1996 • 259 citations

Regulation of tumor growth and metastasis by thrombospondin‐1

1996 • 257 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site

1995 • 249 citations

Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas.

1998 • 249 citations

Transforming growth factor beta: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells.

1988 • 247 citations

Influenza virus neuraminidase activates latent transforming growth factor beta

1996 • 246 citations

Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers.

1996 • 242 citations

Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis.

1993 • 239 citations

Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation ¹

1997 • 227 citations

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

1994 • 219 citations

Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells.

1995 • 216 citations

Prevention of Second Primary Tumors With Isotretinoin in Patients With Squamous Cell Carcinoma of the Head and Neck: Long-term Follow-up

1994 • 208 citations

Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma.

1993 • 208 citations

Elevated Plasma Transforming Growth Factor-β1 Levels in Breast Cancer Patients Decrease After Surgical Removal of the Tumor

1995 • 207 citations

Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

1996 • 197 citations

p53-Independent Role of MDM2 in TGF-β1 Resistance

1998 • 195 citations

Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells.

1996 • 195 citations

Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA.

1993 • 192 citations

Transforming growth factor beta₁ modulates extracellular matrix organization and cell‐cell junctional complex formation during in vitro angiogenesis

1990 • 184 citations

TGF-beta 1 is an autocrine-negative growth regulator of human colon carcinoma FET cells in vivo as revealed by transfection of an antisense expression vector.

1992 • 182 citations

High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer.

1995 • 179 citations

Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: An inventory in search of autocrine and paracrine loops

1998 • 175 citations

Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.

1991 • 174 citations

Association of transforming growth factor-β1 with prostate cancer: An immunohistochemical study

1993 • 170 citations

Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis

1997 • 169 citations

Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis.

1996 • 167 citations

Transforming growth factor β stimulates mamary adenocarcinoma cell invasion and metastasis potential

1990 • 164 citations

DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma.

1996 • 164 citations

Intracellular signalling: The Mad way to do it

1996 • 162 citations

Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis.

1995 • 162 citations

Growth factor expression in normal, benign, and malignant breast tissue

1988 • 161 citations

Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.

1996 • 161 citations

TGF-β singaling and cancer: structural and functional consequences of mutations in Smads

1998 • 160 citations

Differential regulation of expression of three transforming growth factor beta species in human breast cancer cell lines by estradiol.

1990 • 160 citations

TGF-β: A Critical Modulator of Immune Cell Function

1997 • 160 citations

Targeted deletion of Smad4 shows it is required for transforming growth factor β and activin signaling in colorectal cancer cells

1998 • 158 citations

The Royal Marsden Hospital pilot tamoxifen chemoprevention trial

1994 • 156 citations

Resistance to transforming growth factor beta and activin due to reduced receptor expression in human breast tumor cell lines.

1995 • 155 citations

Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1.

1992 • 155 citations

Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma.

1994 • 155 citations

Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breast

1992 • 154 citations

Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer.

1998 • 154 citations

Transforming Growth Factor-β (TGF-β)-induced Down-regulation of Cyclin A Expression Requires a Functional TGF-β Receptor Complex

1995 • 154 citations

Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.

1994 • 150 citations

Mutations of the DPC4/Smad4 gene in biliary tract carcinoma.

1998 • 148 citations

Excessive production of transforming growth-factor β1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth

1992 • 147 citations

Human cytomegalovirus infection induces transcription and secretion of transforming growth factor beta 1

1994 • 146 citations

A Dominant Inhibitory Mutant of the Type II Transforming Growth Factor β Receptor in the Malignant Progression of a Cutaneous T-Cell Lymphoma

1996 • 146 citations

Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1.

1996 • 145 citations

Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells.

1997 • 145 citations

The effect of transforming growth factor-β2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma

1993 • 142 citations

Regression of Oral Leukoplakia With -Tocopherol: A Community Clinical Oncology Program Chemoprevention Study

1993 • 140 citations

The Cat and Mouse Games That Genes, Viruses, and Cells Play

1997 • 138 citations

Increased expression of transforming growth factor beta isoforms and basic fibroblast growth factor in complex hyperplasia and adenocarcinoma of the endometrium: evidence for paracrine and autocrine action.

1994 • 136 citations

Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition

1997 • 134 citations

Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

1995 • 131 citations

Down-regulation of protein and mRNA expression for transforming growth factor-β (TGF-β1) type I and type II receptors in human prostate cancer

1997 • 130 citations

Complex regulation of TGFβ expression by retinoic acid in the vitamin A-deficient rat

1991 • 127 citations

Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas

1997 • 126 citations

Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

1992 • 126 citations

Identification of Important Regions in the Cytoplasmic Juxtamembrane Domain of Type I Receptor That Separate Signaling Pathways of Transforming Growth Factor-β

1996 • 125 citations

A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice.

1997 • 125 citations

Transforming growth factor beta production and responsiveness in normal human melanocytes and melanoma cells.

1994 • 124 citations

Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product.

1991 • 120 citations

Mechanism of retinoid‐induced activation of latent transforming growth factor‐β in bovine endothelial cells

1993 • 118 citations

Overexpression of transforming growth factor (TGF) beta1 type II receptor restores TGF-beta1 sensitivity and signaling in human prostate cancer cells.

1998 • 117 citations

Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor beta 1 levels during monoterpene-induced regression of mammary tumors.

1993 • 114 citations

Loss of expression of transforming growth factor-beta receptors is associated with poor prognosis in prostate cancer patients.

1998 • 113 citations

Serum levels of interleukins, growth factors and anglogenin in patients with endometrial cancer

1997 • 113 citations

Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer.

1996 • 110 citations

Six novel mutations in the endoglin gene in hereditary hemorrhagic telangiectasia type 1 suggest a dominant-negative effect of receptor function

1995 • 109 citations

Macrophage nitric oxide synthesis delays progression of ultraviolet light-induced murine skin cancers.

1993 • 109 citations

Transforming growth factor-beta 1: comparative immunohistochemical localization in human primary and metastatic prostate cancer.

1995 • 108 citations

Localization of transforming growth factor-β isotypes in lesions of the human breast

1992 • 107 citations

Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition

1996 • 107 citations

Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer

1997 • 107 citations

Immunoelectron microscopic localization of transforming growth factor beta 1 and latent transforming growth factor beta 1 binding protein in human gastrointestinal carcinomas: qualitative difference between cancer cells and stromal cells.

1993 • 105 citations

Induction of transforming growth factor-β autocrine activity by all-trans-retinoic acid and 1α,25-dihydroxyvitamin D3 in NRP-152 rat prostatic epithelial cells

1996 • 103 citations

Mutations of the Transforming Growth Factor-β Type II Receptor Gene and Genomic Instability in Hereditary Nonpolyposis Colorectal Cancer

1995 • 103 citations

Production of and responsiveness to transforming growth factor-beta in normal and oncogene-transformed human mammary epithelial cells.

1989 • 102 citations

The Expression of Vascular Endothelial Growth Factor and Transforming Growth Factor-β Associates With Angiogenesis in Epithelial Ovarian Cancer

1997 • 102 citations

Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population.

1996 • 101 citations

Identification of cellular target genes of the Epstein-Barr virus transactivator Zta: activation of transforming growth factor beta igh3 (TGF-beta igh3) and TGF-beta 1

1995 • 100 citations

Structural alterations of transforming growth factor-? receptor genes in human cervical carcinoma

1999 • 100 citations

Genetic alterations in sporadic and Crohn's-associated adenocarcinomas of the small intestine

1997 • 99 citations

A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor beta1.

1998 • 99 citations

Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract.

1998 • 98 citations

Relationship between tamoxifen-induced transforming growth factor beta 1 expression, cytostasis and apoptosis in human breast cancer cells

1995 • 97 citations

Regulation of Transforming Growth Factor α and Transforming Growth Factor β Messenger Ribonucleic Acid Abundance in T-47D, Human Breast Cancer Cells

1989 • 97 citations

Genomic structure of the transforming growth factor beta type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers.

1996 • 96 citations

Low-Dose Isotretinoin Versus -Carotene to Prevent Oral Carcinogenesis: Long-term Follow-up

1997 • 94 citations

Altered Regulation of TGF‐β1 and TGF‐α in Primary Keratinocytes and Papillomas Expressing v‐Ha‐ras

1991 • 94 citations

Expression of transforming growth factor-? (TGF-?) isoforms in osteosarcomas

1997 • 93 citations

Abrogation of Smad3 and Smad2 or of Smad4 Gene Expression Positively Regulates Murine Embryonic Lung Branching Morphogenesis in Culture

1998 • 93 citations

Dpc4 transcriptional activation and dysfunction in cancer cells.

1998 • 90 citations

The prognostic significance of transforming growth factors in human breast cancer

1993 • 90 citations

Evidence for stimulation of the transforming growth factor beta 1 promoter by HIV-1 Tat in cells derived from CNS.

1993 • 88 citations

Transforming growth factor-β-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides

1996 • 88 citations

Mutational analysis of the transforming growth factor beta receptor type II gene in human ovarian carcinoma.

1998 • 87 citations

Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck

1997 • 85 citations

Expression of transforming growth factor beta type II receptor reduces tumorigenicity in human gastric cancer cells.

1997 • 83 citations

Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers

1998 • 82 citations

Up-regulation of Transforming Growth Factor (TGF)-β Receptors by TGF-β1 in COLO-357 Cells

1998 • 80 citations

Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas

1997 • 79 citations

Microsatellite instability and mutations of p53 and TGF-‚ RII genes in gastric cancer

1996 • 77 citations

Spontaneous production of transforming growth factor-beta 2 by primary cultures of bronchial epithelial cells. Effects on cell behavior in vitro.

1992 • 77 citations

Transforming growth factor-beta and cancer: a love-hate relationship?

1997 • 76 citations

Presence of two signaling TGF-beta receptors in human pancreatic cancer correlates with advanced tumor stage.

1997 • 75 citations

Transforming growth factor-beta inhibits proliferation of human ovarian cancer cells obtained from ascites

1994 • 75 citations

Transforming Growth Factor‐β and Hepatocyte Growth Factor Produced by Gastric Fibroblasts Stimulate the Invasiveness of Scirrhous Gastric Cancer Cells

1997 • 73 citations

Establishment of two new scirrhous gastric cancer cell lines: analysis of factors associated with disseminated metastasis

1995 • 72 citations

Regulation of apoptosis in normal and malignant ovarian epithelial cells by transforming growth factor beta.

1995 • 72 citations

Discordant transforming growth factor beta 1 RNA and protein localization during chemical carcinogenesis of the skin.

1992 • 72 citations

Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line.

1994 • 71 citations

Antiproliferative and antitumor activities of D‐reverse peptides derived from the second type‐1 repeat of thrombospondin‐1

1997 • 70 citations

Repression of autocrine transforming growth factor beta 1 and beta 2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties.

1993 • 69 citations

Transfection of the type I TGF-β receptor restores TGF-β responsiveness in pancreatic cancer

1998 • 69 citations

Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.

1993 • 68 citations

Growth Inhibition of Human Pancreatic Carcinoma Cells by Transforming Growth Factor Beta-1

1993 • 67 citations

Escape from transforming growth factor beta control and oncogene cooperation in skin tumor development.

1991 • 67 citations

Reduced surface expression of transforming growth factor beta receptor type II in mitogen-activated T cells from Sézary patients.

1995 • 65 citations

A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene.

1994 • 65 citations

Tamoxifen for the Primary Prevention of Breast Cancer: A Review and Critique of the Concept and Trial

1993 • 64 citations

Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.

1991 • 64 citations

Lack of the latent transforming growth factor beta binding protein in malignant, but not benign prostatic tissue.

1993 • 61 citations

Regulation of transforming growth factor-β subtypes by members of the steroid hormone superfamily

1990 • 61 citations

Transforming growth factor beta as a clinical biomarker for prostate cancer

1997 • 60 citations

Transforming growth factor-beta receptor type 2 mutations and microsatellite instability in sporadic colorectal adenomas and carcinomas.

1997 • 59 citations

Mutation analysis of the transforming growth factor-β type II receptor in human cell lines resistant to growth inhibition by transforming growth factor-β

1997 • 59 citations

Frequent inactivation of the transforming growth factor beta type II receptor in small-cell lung carcinoma cells.

1997 • 58 citations

Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells.

1997 • 58 citations

Effects of transforming growth factor beta 1 on growth and apoptosis of human acute myelogenous leukemia cells.

1993 • 56 citations

Mutations of the transforming growth factor-β type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability

1996 • 56 citations

Loss of transforming growth factor-beta type II receptor gene expression in primary human esophageal cancer.

1996 • 56 citations

Transforming growth factor beta 2 (TGF-beta 2) levels in plasma of patients with metastatic breast cancer treated with tamoxifen.

1995 • 54 citations

A mutation in the transforming growth factor beta type II receptor gene promoter associated with loss of gene expression.

1996 • 54 citations

Transforming growth factor β 1 secreted from scirrhous gastric cancer cells is associated with excess collagen deposition in the tissue

1994 • 54 citations

Altered expression of transforming growth factor-beta 1 in cervical neoplasia as an early biomarker in carcinogenesis of the uterine cervix.

1996 • 54 citations

Mutation analysis of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human colon cancer using genomic DNA and Intron primers

1997 • 54 citations

Expression of transforming growth factor beta mRNA isoforms in human breast cancer

1994 • 52 citations

Comparison of normal and tumorigenic endothelial cells: Differences in thrombospondin production and responses to transforming growth factor-beta

1994 • 52 citations

Cloning of mid-G1 serum response genes and identification of a subset regulated by conditional myc expression.

1994 • 51 citations

Step-wise progression in human skin carcinogenesis in vitro involves mutational inactivation of p53, rasH oncogene activation and additional chromosome loss.

1995 • 51 citations

Overexpression of the tumor suppressor gene Smad4/DPC4 induces p21waf1 expression and growth inhibition in human carcinoma cells.

1998 • 51 citations

Regulation of the steps of angiogenesis by human head and neck squamous cell carcinomas.

1996 • 50 citations

Serum levels of interleukins, growth factors and angiogenin in patients with endometrial cancer

1997 • 50 citations

Expression of transforming growth factors beta-1, beta 2 and beta 3 in human bladder carcinomas

1997 • 50 citations

Expression of transforming growth factor-beta 1 in human bladder cancer

1995 • 47 citations

Differential localization of transforming growth factor-β isoforms in human gastric mucosa and overexpression in gastric carcinoma

1997 • 47 citations

Immunohistochemical study of epidermal growth factor and transforming growth factor-β in the penetrating type of early gastric cancer

1992 • 46 citations

Mutations of the transforming growth factor β type II receptor gene and microsatellite instability in gastric cancer

1996 • 46 citations

Changes in the immunohistochemical localisation of fibroblast growth factor-2, transforming growth factor-β1 and thrombospondin-1 are associated with early angiogenic events in the hyperplastic rat thyroid

1996 • 45 citations

Progressive Loss of Sensitivity to Growth Control by Retinoic Acid and Transforming Growth Factor-Beta at Late Stages of Human Papillomavirus Type 16-Initiated Transformation of Human Keratinocytes

1995 • 45 citations

Growth factor involvement in the multihormonal regulation of MCF-7 breast cancer cell growth in soft agar

1991 • 43 citations

Altered expression of transforming growth factor-β1 in cervical neoplasia as an early biomarker in carcinogenesis of the uterine cervix

1996 • 43 citations

The somatic mutation frequency of the transforming growth factor β receptor type II gene varies widely among different cancers with microsatellite instability

1996 • 42 citations

Transforming growth factor beta secretion from primary breast cancer fibroblasts

1995 • 41 citations

Histomorphological and immunohistochemical characterization of colonic aberrant crypt foci in rats: relationship to growth factor expression

1997 • 40 citations

Immunosuppressive cytokines (IL-10, TGF-β) genes expression in human gastric carcinoma tissues

1996 • 40 citations

Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts

1996 • 39 citations

Effects of transforming growth factor-beta released from gastric carcinoma cells on the contraction of collagen-matrix gels containing fibroblasts.

1991 • 38 citations

Transforming growth factor-?-mediated down-regulation of antitumor cytotoxicity of spleen cells from MOPC-315 tumor-bearing mice engaged in tumor eradication following low-dose melphalan therapy

1994 • 37 citations

Retinoic acid induces secretion of latent transforming growth factor beta 1 and beta 2 in normal and human papillomavirus type 16-immortalized human keratinocytes.

1992 • 37 citations

SHORT COMMUNICATION: Phenobarbital selectively promotes initiated cells with reduced TGFβ receptor levels

1996 • 37 citations

Regulation and Role of TGFβ Production in Breast Cancer^a

1996 • 36 citations

Observations on the origin and significance of the nuclear envelopelimited monolayers of chromatin unit threads associated with the cell nucleus

1973 • 36 citations

Blockade of Transforming Growth Factor-β Signaling Does Not Abrogate Antiestrogen-induced Growth Inhibition of Human Breast Carcinoma Cells

1997 • 35 citations

Antisense oligonucleotide specific for transforming growth factor-beta 1 inhibit both in vitro and in vivo growth of MBT-2 murine bladder cancer.

1998 • 35 citations

HPV16 E6 Oncoprotein Stimulates the Transforming Growth Factor-β1 Promoter in Fibroblasts through a Specific GC-Rich Sequence

1997 • 33 citations

Synthesis and secretion of transforming growth factor beta isoforms by primary cultures of human breast tumour fibroblasts in vitro and their modulation by tamoxifen

1996 • 33 citations

Transforming growth factor–beta1 inhibits generation of angiostatin by human pancreatic cancer cells

1998 • 31 citations

Differential expression of transforming growth factor-?1 and ?3 as well as C-FOS mRNA in normal human prostate, benign prostatic hyperplasia and prostatic cancer

1994 • 31 citations

The role of TGF‐β production in growth inhibition of breast‐tumor cells by progestins

1995 • 30 citations

Potentiation of Metastatic Capacity by Transforming Growth Factor‐β1 Gene Transfection

1993 • 30 citations

Differential Response of Cervical Intraepithelial and Cervical Carcinoma Cell Lines to Transforming Growth Factor-β1

1994 • 29 citations

Challenges: The pharmacological manipulation of members of the transforming growth factor beta family in the chemoprevention of breast cancer

1993 • 28 citations

Transfer of chromosome 18 into human head and neck squamous carcinoma cells: evidence for tumor suppression by Smad4/DPC4.

1997 • 28 citations

Prognostic significance of TGF-beta 1 and TGF-beta 2 expressions in female breast cancer.

1995 • 27 citations

Roles of the transforming growth factor β1 and its type I and II receptors in the development of a pulmonary adenocarcinoma: Results of an immunohistochemical study

1997 • 26 citations

Escape from negative regulation of growth by transforming growth factor β and from the induction of apoptosis by the dietary agent sodium butyrate may be important in colorectal carcinogenesis

1993 • 25 citations

Transfection of the Type II TGF-β Receptor Into Colon Cancer Cells Increases Receptor Expression, Inhibits Cell Growth, and Reduces the Malignant Phenotype

1998 • 24 citations

Estrogen-induced tumorigenesis in the pituitary gland of TGF-β(+/−) knockout mice

1998 • 23 citations

Transforming growth factor beta 1 induction is associated with transforming growth factors beta 2 and beta 3 down-modulation in 12-O-tetradecanoylphorbol-13-acetate-induced skin hyperplasia.

1993 • 22 citations

Langerhans Cells in the TGFβ1 Null Mouse

1997 • 22 citations

Transforming growth factor-beta 1 induces growth inhibition of a human medullary thyroid carcinoma cell line despite an increase in steady state c-myc messenger ribonucleic acid levels.

1994 • 21 citations

Lack of transforming growth factor-β type II receptor expression in human retinoblastoma cells

1998 • 21 citations

The Conventional Transforming Growth Factor-β (TGF-β) Receptor Type I Is Not Required for TGF-β1 Signaling in a Human Prostate Cancer Cell Line, LNCaP

1998 • 19 citations

Functional characterization of transforming growth factor beta type II receptor mutants in human cancer.

1998 • 18 citations

TGF-beta1 in colonic neoplasia: a genetic molecular and immunohistochemical study.

1997 • 18 citations

Mutation of the transforming growth factor-beta type II receptor gene is a rare event in human sporadic gastric carcinomas.

1998 • 17 citations

Distribution of Transforming Growth Factor‐β and Its Receptors in Gastric Carcinoma Tissue

1996 • 16 citations

Oncogene and Cytokine Expression of Human Colorectal Tumors Responding to Immunotherapy

1997 • 15 citations

Transcriptional Activation of the c-myc Proto-Oncogene in Murine Keratinocytes Enhances the Response to Epidermal Growth Factor

1989 • 14 citations

Plasma transforming growth factor beta levels in breast cancer patients.

1998 • 13 citations

High level of beta-type transforming growth factor activity in human urine obtained from cancer patients.

1986 • 11 citations

Transforming growth factor-beta and suppression of carcinogenesis.

1989 • 10 citations

Relationship of transforming growth factor beta 1 to angiogenesis in gastric carcinoma

1997 • 9 citations

A novel missense mutation and frameshift mutations in the type II receptor of transforming growth factor-β gene in sporadic colon cancer with microsatellite instability

1998 • 9 citations

TGF-beta 1 in colonic neoplasia. A genetic molecular and immunohistochemical study.

1996 • 7 citations

Transforming growth factor beta‐1 (TGF‐β1) released by an Epstein‐Barr virus (EBV) positive spontaneous lymphoblastoid cell line from a patient with Kostmann's congenital neutropenia inhibits the growth of normal committed haemopoietic progenitors in vitro

1993 • 4 citations