Transforming growth factor-beta 1 induces growth inhibition of a human medullary thyroid carcinoma cell line despite an increase in steady state c-myc messenger ribonucleic acid levels.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation

1993 • 348 citations

The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells

1991 • 330 citations

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

1991 • 279 citations

Modulation of Transforming Growth Factor-βProduction in Normal Human Osteoblast-Like Cells by 17β-Estradiol and Parathyroid Hormone

1991 • 271 citations

Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration

1989 • 266 citations

In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1.

1992 • 190 citations

Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer.

1991 • 177 citations

Transforming growth factor-β 1 as a signal for induction of cell death by apoptosis

1993 • 173 citations

Effect of transforming growth factor beta on cell death of cultured rat hepatocytes.

1991 • 166 citations

Transforming growth factor beta 1 induces apoptotic cell death in cultured human gastric carcinoma cells.

1992 • 152 citations

Apoptosis is induced by transforming growth factor-beta 1 within 5 hours in regressing liver without significant fragmentation of the DNA.

1993 • 142 citations

Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells.

1987 • 116 citations

TGF‐β inhibits growth factor‐induced DNA synthesis in hamster fibroblasts without affecting the early mitogenic events

1988 • 99 citations

Phorbol esters increase calcitonin gene transcription and decrease c-myc mRNA levels in cultured human medullary thyroid carcinoma.

1985 • 90 citations

Induction of apoptosis in cultured hepatocytes and in the regressing liver by transforming growth factor-β1 occurs without activation of an endonuclease

1992 • 64 citations

Modulation of C-myc by transforming growth factor-β in human colon carcinoma cells

1988 • 64 citations

Effects of transforming growth factor beta 1 on growth and apoptosis of human acute myelogenous leukemia cells.

1993 • 56 citations

Immunofluorescent plasma cell labeling indices (LI) using a monoclonal antibody (BU‐1)

1985 • 53 citations

The Molecular Biology of Medullary Thyroid Carcinoma

1989 • 44 citations

TGF beta inhibits Go/S-phase transition in primary fibroblasts. Loss of response to the antigrowth effect of TGF beta is observed after immortalization.

1989 • 41 citations