TGF-β: A Critical Modulator of Immune Cell Function

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)

1993 • 755 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

Latent transforming growth factor-β: Structural features and mechanisms of activation

1997 • 511 citations

Transforming growth factor beta: the good, the bad, and the ugly.

1994 • 491 citations

A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells

1996 • 479 citations

Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism

1992 • 439 citations

Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.

1996 • 423 citations

Tumor suppressor activity of the TGF-β pathway in human cancers

1996 • 412 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

1997 • 397 citations

Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1.

1991 • 385 citations

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

1993 • 356 citations

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.

1996 • 341 citations

TGF-beta 1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors.

1996 • 312 citations

Transforming growth factor β: a matter of life and death

1994 • 306 citations

Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

1994 • 274 citations

Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

1991 • 266 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression.

1995 • 222 citations

High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis.

1996 • 221 citations

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

1994 • 219 citations

SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-beta knockout mice.

1995 • 184 citations

Signal transduction by members of the transforming growth factor-β superfamily

1996 • 160 citations

Trypanosome invasion of mammalian cells requires activation of the TGFβ signaling pathway

1995 • 158 citations

Oral Tolerance to Myelin Basic Protein Induces Regulatory TGF-β-Secreting T Cells in Peyer's Patches of SJL Mice

1994 • 151 citations

A Dominant Inhibitory Mutant of the Type II Transforming Growth Factor β Receptor in the Malignant Progression of a Cutaneous T-Cell Lymphoma

1996 • 146 citations

An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice.

1991 • 139 citations

Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis

1992 • 134 citations

A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice.

1997 • 125 citations

Latency and activation in the control of TGF-β

1996 • 121 citations

TGF-beta 1 promotes in vitro generation of dendritic cells by protecting progenitor cells from apoptosis.

1997 • 115 citations

Pleiotropic Effects of Transforming Growth Factor‐β on Cells of the Immune System

1993 • 87 citations

Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice.

1994 • 85 citations

Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta.

1994 • 82 citations

Long-term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β2

1993 • 74 citations

A first or dominant immunization. II. Induced immunoglobulin carries transforming growth factor beta and suppresses cytolytic T cell responses to unrelated alloantigens.

1993 • 68 citations

Intracellular demonstration of active TGFbeta1 in B cells and plasma cells of autoimmune mice. IgG-bound TGFbeta1 suppresses neutrophil function and host defense against Staphylococcus aureus infection.

1996 • 61 citations

Modulation of B16 Melanoma Growth and Metastasis by Anti-Transforming Growth Factor ?? Antibody and Interleukin-2

1996 • 59 citations

Gene Transfer of Transforming Growth Factor-β1 Prolongs Murine Cardiac Allograft Survival by Inhibiting Cell-Mediated Immunity

1996 • 55 citations

Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture.

1995 • 49 citations

Suppression of carcinogenesis: a role for TGF-beta and related molecules in prevention of cancer.

1990 • 48 citations

Up-regulation of cytokine mRNA, adhesion molecule proteins, and MHC class II proteins in salivary glands of TGF-beta1 knockout mice: MHC class II is a factor in the pathogenesis of TGF-beta1 knockout mice.

1997 • 45 citations

Transforming growth factor-?-mediated down-regulation of antitumor cytotoxicity of spleen cells from MOPC-315 tumor-bearing mice engaged in tumor eradication following low-dose melphalan therapy

1994 • 37 citations

Anti-(transforming growth factor ?) antibodies with predefined specificity inhibit metastasis of highly tumorigenic human xenotransplants in nu/nu mice

1995 • 36 citations

Transforming growth factor-β receptors: Role in physiology and disease

1996 • 29 citations

Molecular Biology of Hematopoiesis 5

1996 • 27 citations

Early human thymocyte proliferation is regulated by an externally controlled autocrine transforming growth factor-beta 1 mechanism

1995 • 25 citations

Autoantibodies produced spontaneously by young 1pr mice carry transforming growth factor beta and suppress cytotoxic T lymphocyte responses.

1995 • 24 citations

Molecular Biology of Hematopoiesis

1996 • 19 citations