Transfection of the Type II TGF-β Receptor Into Colon Cancer Cells Increases Receptor Expression, Inhibits Cell Growth, and Reduces the Malignant Phenotype

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Spontaneous mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA

1988 • 773 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.

1995 • 445 citations

Tumor suppressor activity of the TGF-β pathway in human cancers

1996 • 412 citations

Regulation of intestinal epithelial cell growth by transforming growth factor type beta.

1989 • 341 citations

Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells

1995 • 340 citations

Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor

1989 • 325 citations

Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells

1994 • 325 citations

Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

1995 • 292 citations

Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.

1993 • 252 citations

Growth modulation of mouse keratinocytes by transforming growth factors.

1988 • 242 citations

TGF‐β Receptors and TGF‐β Binding Proteoglycans: Recent Progress in Identifying Their Functional Properties

1990 • 233 citations

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

1993 • 224 citations

Growth factor production by human colon carcinoma cell lines.

1989 • 186 citations

Differential sensitivity of subclasses of human colon carcinoma cell lines to the growth inhibitory effects of transforming growth factor-β1

1989 • 142 citations

[17] Identification of receptor for type-β transforming growth factor

1987 • 134 citations

TGF-β expression in the human colon: differential immunostaining along crypt epithelium

1993 • 113 citations

Superantigen can reactivate bacterial cell wall-induced arthritis.

1993 • 88 citations

Both transforming growth factor-beta and substrate release are inducers of apoptosis in a human colon adenoma cell line.

1995 • 83 citations

Inhibitory Effects of Transforming Growth Factor β1 on Mitogenic Response, Transforming Growth Factor α, and c-myc in Quiescent, Well-Differentiated Colon Carcinoma Cells

1990 • 47 citations

Characterization of transforming growth factor-beta-resistant subclones isolated from a transforming growth factor-beta-sensitive human colon carcinoma cell line.

1988 • 37 citations

Colon Cancer Cells That Are Not Growth Inhibited by TGF-β Lack Functional Type I and Type II TGF-β Receptors

1995 • 32 citations

Inhibitory effects of transforming growth factor beta 1 on mitogenic response, transforming growth factor alpha, and c-myc in quiescent, well-differentiated colon carcinoma cells.

1990 • 19 citations

Pharmacokinetics of TGFβ with Emphasis on Effects in Liver and Gut

1990 • 14 citations