Transforming growth factor beta production and responsiveness in normal human melanocytes and melanoma cells.

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines.

1985 • 344 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.

1990 • 319 citations

TGF-beta 1 is an autocrine-negative growth regulator of human colon carcinoma FET cells in vivo as revealed by transfection of an antisense expression vector.

1992 • 182 citations

Constitutive Expression of Multiple Growth Factor Genes by Melanoma Cells but Not Normal Melanocytes

1991 • 176 citations

Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.

1991 • 174 citations

The autocrine production of transforming growth factor-beta 1 during lymphocyte activation. A study with a monoclonal antibody-based ELISA.

1990 • 169 citations

Induction of growth factor RNA expression in human malignant melanoma: markers of transformation.

1991 • 151 citations

Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors

1987 • 145 citations

Differential sensitivity of subclasses of human colon carcinoma cell lines to the growth inhibitory effects of transforming growth factor-β1

1989 • 142 citations

Growth stimulation of human breast cancer cells with anti-transforming growth factor beta antibodies: evidence for negative autocrine regulation by transforming growth factor beta.

1990 • 118 citations

Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas.

1989 • 108 citations

TGFβ₁ and TGFβ₂ are potential growth regulators for low‐grade and malignant gliomas in vitro: Evidence in support of an autocrine hypothesis

1991 • 107 citations

Localization of transforming growth factor-β isotypes in lesions of the human breast

1992 • 107 citations

Transforming growth factor beta 1 acts as an autocrine-negative growth regulator in colon enterocytic differentiation but not in goblet cell maturation.

1990 • 91 citations

Expression of melanoma-associated antigens in rapidly dividing human melanocytes in culture.

1987 • 83 citations

Inhibition of Metastases of a Human Melanoma Xenograft by Monoclonal Antibody to the GD2/GD3 Gangliosides

1989 • 83 citations

Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.

1991 • 64 citations

Evidence That TGF-β Can Inhibit Human T-Lymphocyte Proliferation through Paracrine and Autocrine Mechanisms

1993 • 60 citations

Development of resistance to the growth inhibitory effects of transforming growth factor beta 1 during the spontaneous transformation of rat liver epithelial cells.

1991 • 58 citations

Transforming growth factor beta (TGF-beta) type V receptor has a TGF-beta-stimulated serine/threonine-specific autophosphorylation activity.

1992 • 48 citations

Two novel patterns of transforming growth factor beta (TGF-beta) binding to cell surface proteins are dependent upon the binding of TGF-beta 1 and indicate a mechanism of positive cooperativity.

1992 • 35 citations

SV40-transfected human melanocyte sensitivity to growth inhibition by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

1989 • 27 citations

Differentiation of malignant oral rat keratinocytes reflects changes in EGF and TGF-β receptor expression but not growth factor dependence

1991 • 16 citations

Generation of antibodies and assays for transforming growth factor β

1991 • 14 citations