A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor beta1.

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development.

1991 • 677 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.

1990 • 398 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Frequency of Smad gene mutations in human cancers.

1997 • 289 citations

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.

1988 • 273 citations

Association of transforming growth factor-β1 with prostate cancer: An immunohistochemical study

1993 • 170 citations

Microvascular pericytes express platelet-derived growth factor-beta receptors in human healing wounds and colorectal adenocarcinoma.

1993 • 144 citations

Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice.

1993 • 138 citations

Increased expression of transforming growth factor beta isoforms and basic fibroblast growth factor in complex hyperplasia and adenocarcinoma of the endometrium: evidence for paracrine and autocrine action.

1994 • 136 citations

Transforming growth factor-β and the immune system

1991 • 103 citations

Colon carcinoma cells switch their response to transforming growth factor beta 1 with tumor progression.

1994 • 87 citations

Role of transforming growth factor beta 1 in induction of colon carcinoma differentiation by hexamethylene bisacetamide.

1990 • 76 citations

Growth Inhibitory Effects of Transforming Growth Factor-β1 in vivo

1991 • 71 citations

Platelet‐derived growth factor‐B increases colon cancer cell growth in vivo by a paracrine effect

1995 • 58 citations

Two roles for transforming growth factor beta 1 in colon enterocytic cell differentiation.

1992 • 42 citations

Transforming growth factor beta 1 (TGF-beta 1) inhibits retinoblastoma gene expression but not pRB phosphorylation in TGF-beta 1-growth stimulated colon carcinoma cells.

1992 • 40 citations

TGFβ1 and TGFβ2 are potential growth regulators for medulloblastomas, primitive neuroectodermal tumors, and ependymomas: Evidence in support of an autocrine hypothesis

1994 • 38 citations

The capacity for growth stimulation by TGF beta 1 seen only in advanced colon cancers cannot be ascribed to mutations in APC, DCC, p53 or ras.

1994 • 27 citations

Heterogeneous responses of human colon carcinomas to hexamethylene bisacetamide.

1988 • 19 citations