Functional characterization of transforming growth factor beta type II receptor mutants in human cancer.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

Establishment and characterization of a cell line of human breast carcinoma origin

1979 • 653 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.

1993 • 276 citations

Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis.

1993 • 239 citations

Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells.

1995 • 216 citations

Signaling Activity of Transforming Growth Factor β Type II Receptors Lacking Specific Domains in the Cytoplasmic Region

1993 • 207 citations

Inhibition of growth by transforming growth factor-beta following fusion of two nonresponsive human carcinoma cell lines. Implication of the type II receptor in growth inhibitory responses.

1992 • 176 citations

The extracellular regulation of growth factor action.

1992 • 176 citations

Regulation of transforming growth factor β- and activin-induced transcription by mammalian Mad proteins

1996 • 162 citations

Intracellular signalling: The Mad way to do it

1996 • 162 citations

Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.

1996 • 161 citations

Resistance to transforming growth factor beta and activin due to reduced receptor expression in human breast tumor cell lines.

1995 • 155 citations

Transforming Growth Factor-β (TGF-β)-induced Down-regulation of Cyclin A Expression Requires a Functional TGF-β Receptor Complex

1995 • 154 citations

Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis.

1994 • 152 citations

Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells.

1994 • 151 citations

A Dominant Inhibitory Mutant of the Type II Transforming Growth Factor β Receptor in the Malignant Progression of a Cutaneous T-Cell Lymphoma

1996 • 146 citations

Inhibition of Capillary Morphogenesis and Associated Apoptosis by Dominant Negative Mutant Transforming Growth Factor-β Receptors

1995 • 142 citations

DPC4 (SMAD4) mediates transforming growth factor-β1 (TGF-β1) induced growth inhibition and transcriptional response in breast tumour cells

1997 • 134 citations

Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues

1997 • 125 citations

Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases.

1995 • 116 citations

Ligand-independent Activation of Transforming Growth Factor (TGF) β Signaling Pathways by Heteromeric Cytoplasmic Domains of TGF-β Receptors

1996 • 108 citations

Mutations of the Transforming Growth Factor-β Type II Receptor Gene and Genomic Instability in Hereditary Nonpolyposis Colorectal Cancer

1995 • 103 citations

Genomic structure of the transforming growth factor beta type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers.

1996 • 96 citations

Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers

1998 • 82 citations

Reconstitution and transphosphorylation of TGF-beta receptor complexes.

1994 • 81 citations

Transforming growth factor-beta and cancer: a love-hate relationship?

1997 • 76 citations

Identification of a hepatocyte growth factor autocrine loop in a murine mammary carcinoma.

1996 • 66 citations

Inactive Type II and Type I Receptors for TGFβ Are Dominant Inhibitors of TGFβ-dependent Transcription

1995 • 54 citations

Biological effects and binding properties of transforming growth factor-β on human oral squamous cell carcinoma cells

1990 • 51 citations

High Frequency of Resistance of Human Squamous Carcinoma Cells to the Anti-proliferative Action of Transforming Growth Factor β

1990 • 37 citations

The role of TGF‐β production in growth inhibition of breast‐tumor cells by progestins

1995 • 30 citations

Fibronectin and its alpha 5 beta 1 integrin receptor in malignancy.

1994 • 28 citations

Transfer of chromosome 18 into human head and neck squamous carcinoma cells: evidence for tumor suppression by Smad4/DPC4.

1997 • 28 citations

Reinitiation of DNA synthesis in quiescent mouse keratinocytes; Regulation by polypeptide hormones, cholera toxin, dexamethasone, and retinoic acid

1988 • 20 citations