Replication Timing of Genes and Middle Repetitive Sequences

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A rapid boiling method for the preparation of bacterial plasmids

1981 • 3,334 citations

Gene Regulation for Higher Cells: A Theory

1969 • 2,022 citations

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

1980 • 1,884 citations

Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure

1979 • 1,403 citations

Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution

1975 • 1,188 citations

Expression of human immune interferon cDNA in E. coli and monkey cells

1982 • 703 citations

Erythroleukemic Differentiation

1978 • 694 citations

Highly Repeated Sequences in Mammalian Genomes

1982 • 657 citations

Regulation of Gene Expression: Possible Role of Repetitive Sequences

1979 • 575 citations

Three abundance classes in HeLa cell messenger RNA

1974 • 563 citations

Active chromatin

1982 • 549 citations

A bacterial clone synthesizing proinsulin.

1978 • 515 citations

Structure of the human immune interferon gene

1982 • 510 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Eucaryotic DNA: Organization of the genome for replication

1978 • 476 citations

Heterochromatin

1966 • 462 citations

The Phenomenon of Position Effect

1950 • 436 citations

α-globin-gene switching during the development of chicken embryos: Expression and chromosome structure

1981 • 353 citations

Multienzyme complex for metabolic channeling in mammalian DNA replication.

1980 • 349 citations

The general affinity of lac repressor for E. coli DNA: Implications for gene regulation in procaryotes and eucaryotes

1975 • 341 citations

Cloned human phenylalanine hydroxylase gene allows prenatal diagnosis and carrier detection of classical phenylketonuria

1983 • 334 citations

Structure of mouse metallothionein-I gene and its mRNA

1981 • 301 citations

Characterization of Giemsa dark- and light-band DNA

1982 • 251 citations

Isolation and characterization of the mouse metallothionein-I gene.

1980 • 210 citations

Molecular events in the reproduction of animal cells. I. The effect of puromycin on the duplication of DNA.

1962 • 207 citations

Sequence homology between human .alpha.1-antichymotrypsin, .alpha.1-antitrypsin, and antithrombin III

1983 • 204 citations

Mid-prophase human chromosomes. The attainment of 2000 bands

1981 • 198 citations

Analysis of the complexity and diversity of mRNA from chicken liver and oviduct

1976 • 184 citations

Common 82-nucleotide sequence unique to brain RNA.

1982 • 177 citations

Definition of 5‘ and 3‘ structural boundaries of the chromatin domain containing the ovalbumin multigene family.

1982 • 172 citations

Genetic Expression in the Developing Brain

1983 • 167 citations

The distribution of interspersed repeats is nonuniform and conserved in the mouse and human genomes.

1983 • 151 citations

Changes in gene position are accompanied by a change in time of replication

1984 • 147 citations

Sequence complexity of nuclear RNAs in adult rat tissues

1978 • 146 citations

Genes transcribed at diverse rates have a similar conformation in chromatin

1977 • 140 citations

Cloning of cDNA for argininosuccinate synthetase mRNA and study of enzyme overproduction in a human cell line.

1981 • 135 citations

Patterns of DNA replication of human chromosomes. II. Replication map and replication model.

1982 • 132 citations

Mitotic Synchrony in Mammalian Cells Treated with Nitrous Oxide at High Pressure

1968 • 125 citations

A three-allele restriction-fragment-length polymorphism at the hypoxanthine phosphoribosyltransferase locus in man.

1983 • 122 citations

Polysome immunoprecipitation of phenylalanine hydroxylase mRNA from rat liver and cloning of its cDNA.

1982 • 113 citations

Isolation of cDNA clones coding for rat tyrosine aminotransferase.

1982 • 111 citations

Effect of cell proliferation on levels and diversity of poly(A)-containing mRNA

1976 • 111 citations

Active conformation of the globin genes in uninduced and induced mouse erythroleukemia cells

1978 • 110 citations

The temporal order of replication of murine immunoglobulin heavy chain constant region sequences corresponds to their linear order in the genome

1982 • 93 citations

Nucleotide sequence of cloned cDNA of human apolipoprotein A-l

1983 • 88 citations

Intronless human dihydrofolate reductase genes are derived from processed RNA molecules.

1982 • 88 citations

Molecular events in the reproduction of animal cells

1964 • 75 citations

The temporal structure of S phase

1975 • 75 citations

Replication of alpha and beta globin DNA sequences occurs during early S phase in murine erythroleukemia cells.

1981 • 71 citations

alpha-Globulin sequences are located in a region of early-replicating DNA in murine erythroleukemia cells.

1981 • 71 citations

Repetitive DNA sequences cotranscribed with developmentally regulated Dictyostelium discoideum mRNAs.

1981 • 69 citations

Evidence for a correlation between late replication and autosomal gene inactivation in a familial translocation t(X;21)

1979 • 66 citations

Changes in chromosomal DNA replication patterns in developing frog embryos

1970 • 61 citations

Late replication in an X-autosome translocation in the mouse: correlation with genetic inactivation and evidence for selective effects during embryogenesis.

1979 • 61 citations

Hot spots and functional organization of human chromosomes

1978 • 58 citations

Localization of sequences specifying messenger RNA to light-staining G-bands of human chromosomes

1977 • 58 citations

High resolution analysis of the timing of replication of specific DNA sequences during S phase of mammalian cells

1983 • 56 citations

Dispersion of argininosuccinate synthetase-like human genes to multiple autosomes and the X chromosome

1982 • 56 citations

Time of replication of genes responsible for a temperature‐sensitive function in a cell cycle‐specific ts mutant from a hamster cell line

1977 • 54 citations

High-frequency mutation at the adenine phosphoribosyltransferase locus in Chinese hamster ovary cells due to deletion of the gene.

1983 • 52 citations

Mobile Dispersed Genetic Elements and Other Middle Repetitive DNA Sequences in the Genomes of Drosophila and Mouse: Transcription and Biological Significance

1981 • 51 citations

cDNA sequences of human glucose 6-phosphate dehydrogenase cloned in pBR322

1981 • 51 citations

Construction and preliminary characterization of the rat casein and alpha-lactalbumin cDNA clones.

1981 • 49 citations

Spreading of inactivation in an (X;14) translocation

1978 • 44 citations

Perturbation of growth and differentiation of friend murine erythroleukemia cells by 5‐bromodeoxyuridine incorporation in early S phase

1979 • 43 citations

Characteristics of HeLa strains: Permanent vs. variable features

1980 • 42 citations

Differential sensitivity to 5-bromodeoxyuridine during the S phase of synchronized myogenic cells

1976 • 37 citations

The relationship between repetitive DNA and chromosomal bands in man

1974 • 33 citations

Physical relationship between replicons and transcription units in Physarum polycephalum.

1982 • 33 citations

Early and late replication patterns of increased resolution in human lymphocyte chromosomes

1981 • 27 citations

Linkage arrangement of human placental lactogen and growth hormone genes.

1982 • 26 citations

Location of Ala32 gene replication in the cell cycle of cultured mammalian cells, L5178Y

1975 • 24 citations

Replication of Repetitious DNA and the S Period

1970 • 22 citations

Amplified dihydrofolate reductase genes are located in chromosome regions containing DNA that replicates during the first half of S-phase.

1982 • 16 citations

Computer image analysis of variance between human chromosome replication sequences and G-bands.

1982 • 9 citations

Chromosomal replication asynchrony of a human breast carcinoma cell line. I. Studied by continuous BrdU incorporation and G-banding analysis

1982 • 8 citations

Replication-dependent transcription in eukaryotes

1976 • 7 citations