Specificities of the Saccharomyces cerevisiae rad6, rad18, and rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative nonessential DNA polymerase.

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

Improved method for high efficiency transformation of intact yeast cells

1992 • 3,258 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

A constant rate of spontaneous mutation in DNA-based microbes.

1991 • 1,194 citations

MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES

1986 • 884 citations

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

1987 • 731 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

Triplet repeat mutations in human disease

1992 • 417 citations

The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions

1990 • 386 citations

Characterization of Double-Strand Break-Induced Recombination: Homology Requirements and Single-Stranded DNA Formation

1992 • 377 citations

Transcription and processing of intervening sequences in yeast tRNA genes

1978 • 332 citations

Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites.

1994 • 318 citations

DNA REPAIR GENES AND PROTEINS OF SACCHAROMYCES CEREVISIAE

1993 • 301 citations

Characterization of postreplication repair in Saccharomyces cerevisiae and effects of rad6, rad18, rev3 and rad52 mutations

1981 • 289 citations

REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase

1989 • 270 citations

Yeast chromosome replication and segregation

1988 • 250 citations

Dominant negative alleles of RAD52 reveal a DNA repair/recombination complex including Rad51 and Rad52.

1993 • 228 citations

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase

1991 • 187 citations

Mutagenesis in Saccharomyces Cerevisiae

1982 • 181 citations

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

1993 • 177 citations

DNA, mutations and aging

1989 • 158 citations

Mutation of cysteine-88 in the Saccharomyces cerevisiae RAD6 protein abolishes its ubiquitin-conjugating activity and its various biological functions.

1990 • 155 citations

DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiae.

1993 • 141 citations

Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease.

1994 • 98 citations

Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA

1976 • 98 citations

THE EFFECTS OF THREE PSO GENES ON INDUCED MUTAGENESIS: A NOVEL CLASS OF MUTATIONALLY DEFECTIVE YEAST

1980 • 97 citations

Specificity of the yeast rev3 delta antimutator and REV3 dependency of the mutator resulting from a defect (rad1 delta) in nucleotide excision repair.

1994 • 93 citations

Yeast open reading frame YCR14C encodes a DNA β-polymerase-like enzyme

1993 • 79 citations

Spontaneous mutagenesis: the roles of DNA repair, replication, and recombination

1985 • 79 citations

PCNA-induced DNA synthesis pastcis-syn andtrans-syn-l thymine dimers by calf thymus DNA polymeraseδ in vitro

1992 • 73 citations

DNA synthesis in UV-irradiated yeast

1981 • 71 citations

Mutations in RAD6, a yeast gene encoding a ubiquitin-conjugating enzyme, stimulate retrotransposition.

1990 • 69 citations

Development of a yeast system to assay mutational specificity

1987 • 65 citations

Allelism between pso1-1 and rev3-1 mutants and between pso2-1 and snm1 mutants in Saccharomyces cerevisiaee

1988 • 63 citations

Mutational specificity of DNA precursor pool imbalances in yeast arising from deoxycytidylate deaminase deficiency or treatment with thymidylate

1991 • 60 citations

MCB elements and the regulation of DNA replication genes in yeast

1993 • 59 citations

Isolation of a yeast gene involved in species-specific pre-tRNA processing.

1988 • 57 citations

Elimination of the yeast RAD6 ubiquitin conjugase enhances base-pair transitions and G.C----T.A transversions as well as transposition of the Ty element: implications for the control of spontaneous mutation.

1992 • 56 citations

Specificity of the mutator effect caused by disruption of the RAD1 excision repair gene of Saccharomyces cerevisiae

1990 • 44 citations

The yeast rad18 mutator specifically increases G.C----T.A transversions without reducing correction of G-A or C-T mismatches to G.C pairs.

1991 • 43 citations

The role of PSO and SNM genes in DNA repair of the yeast Saccharomyces cerevisiae

1990 • 43 citations

The REV3 gene of Saccharomyces cerevisiae is transcriptionally regulated more like a repair gene than one encoding a DNA polymerase

1992 • 36 citations

Disruption of the RAD52 gene alters the spectrum of spontaneous SUP4-o mutations in Saccharomyces cerevisiae.

1989 • 33 citations

In vitro mutagenesis of the yeast SUP4‐o gene to identify all substitutions that can be detected in vivo with the SUP4‐o system

1992 • 17 citations