How much do we know about spontaneous human mutation rates?

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

Fundamentals of molecular evolution

1991 • 1,721 citations

A constant rate of spontaneous mutation in DNA-based microbes.

1991 • 1,194 citations

Our load of mutations.

1950 • 685 citations

The Effect of Variation of Fitness

1937 • 631 citations

The rate of spontaneous mutation of a human gene

1935 • 510 citations

MUTATION RATE AND DOMINANCE OF GENES AFFECTING VIABILITY IN DROSOPHILA MELANOGASTER

1972 • 494 citations

THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. I. SPONTANEOUS MUTATION RATE OF POLYGENES CONTROLLING VIABILITY

1964 • 465 citations

Fundamentals of molecular evolution

1991 • 353 citations

Spontaneous Mutation in Man

1975 • 346 citations

Nature's chemicals and synthetic chemicals: comparative toxicology.

1990 • 275 citations

THE MUTATION RATE OF THE GENE FOR HAEMOPHILIA, AND ITS SEGREGATION RATIOS IN MALES AND FEMALES

1946 • 226 citations

Efficiency of truncation selection

1979 • 204 citations

Ageing and mutation in plants

1989 • 185 citations

The Viability of Near-normal Irradiated Chromosomes

1959 • 140 citations

The genomic mutation rate for fitness in Drosophila

1992 • 133 citations

Achondroplasia—a genetic and statistical survey

1970 • 127 citations

Frequency and nature of specific-locus mutations induced in female mice by radiations and chemicals: a review

1992 • 109 citations

Evidence for the Partial Dominance of Recessive Lethal Genes in Natural Populations of Drosophila

1964 • 104 citations

The rate with which spontaneous mutation alters the electrophoretic mobility of polypeptides.

1986 • 82 citations

THE INFLUENCE OF EPISTASIS ON HOMOZYGOUS VIABILITY DEPRESSION IN DROSOPHILA MELANOGASTER

1969 • 67 citations

Population biology of genes and molecules

1990 • 67 citations

SELECTION DIFFERENTIALS AND SELECTION COEFFICIENTS

1978 • 65 citations

HOMOZYGOUS VIABILITY AND FERTILITY LOADS IN DROSOPHILA MELANOGASTER

1966 • 50 citations

Changing paternal age distribution and the human mutation rate in Europe

1990 • 17 citations