N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

Molecular Cloning: A Laboratory Manual

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Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

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Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes.

1989 • 1,295 citations

DNA methylation and the frequency of CpG in animal DNA

1980 • 1,146 citations

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.

1987 • 1,087 citations

Probability and statistical inference

2008 • 913 citations

DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory.

1983 • 895 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Analysis of Mutation in Human Cells by Using an Epstein-Barr Virus Shuttle System

1987 • 513 citations

Fidelity of DNA polymerases in DNA amplification.

1989 • 487 citations

Oncogene Activation in Chemical Carcinogenesis

1988 • 383 citations

Mismatch amplification mutation assay (MAMA): application to the c-H-ras gene.

1992 • 379 citations

Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.

1989 • 338 citations

Endogenous DNA damage as related to cancer and aging

1989 • 323 citations

Activated Oncogenes in B6C3F1 Mouse Liver Tumors: Implications for Risk Assessment

1987 • 279 citations

Activation of ras Oncogenes Preceding the Onset of Neoplasia

1990 • 261 citations

DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.

1987 • 233 citations

Probability and Statistical Inference

1989 • 214 citations

Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines

1990 • 210 citations

Endogenous carcinogenesis: molecular oncology into the twenty-first century--presidential address.

1989 • 189 citations

Activation of a c-K- ras Oncogene by Somatic Mutation in Mouse Lymphomas Induced by Gamma Radiation

1984 • 180 citations

Predisposition to Neoplastic Transformation Caused by Gene Replacement of H- ras 1

1993 • 117 citations

Evidence that binding of 7,12-dimethylbenz(a)anthracene to DNA in mouse embryo cell cultures results in extensive substitution of both adenine and guanine residues.

1983 • 116 citations

Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids.

1992 • 93 citations

Induction of 6‐thioguanine‐resistant lymphocytes in fischer 344 rats following in vivo exposure to n‐ethyl‐n‐nitrosourea and cyclophosphamide

1991 • 92 citations

Hypomethylation of DNA in Raji cells after treatment with N-methyl-N-nitrosourea

1981 • 60 citations

Reduction in the frequency of activated ras oncogenes in rat mammary carcinomas with increasing N-methyl-N-nitrosourea doses or increasing prolactin levels.

1990 • 48 citations

Inhibition of the ligase step of excision repair by 2-chloroethyl isocyanate, a decomposition product of 1,3-bis(2-chloroethyl)-1-nitrosourea.

1978 • 46 citations

Mutagenesis of the K-ras protooncogene in mouse lung tumors induced by N-ethyl-N-nitrosourea or N-nitrosodiethylamine

1992 • 45 citations

Ha-ras oncogene activation in mammary glands of N-methyl-N-nitrosourea-treated rats genetically resistant to mammary adenocarcinogenesis.

1992 • 42 citations

Mammary gland growth of rats between 10 and 100 days of age

1966 • 41 citations

O6-methylguanine accumulates in DNA of mammary glands after administration of N-methyl-N-nitrosourea to rats

1979 • 23 citations

Spontaneous and induced chromosomal aberrations and gene mutations in human lymphoblasts: mitomycin C, methylnitrosourea, and ethylnitrosourea

1986 • 21 citations

Effects of nitrosoureas on human DNA polymerase activities from acute and chronic granulocytic leukemia cells

1976 • 19 citations

Radiation and chemical activation of ras oncogenes in different mouse strains.

1989 • 18 citations

Formation and repair of O6-methylguanine and methylation of the Ha-ras proto-oncogene by N-methyl-N-nitrosourea are not associated with mammary tumor resistance in the Copenhagen rat

1992 • 16 citations

Nonrandom distribution of O6-methylguanine in H-ras gene sequence from DNA modified with N-methyl-N-nitrosourea

1993 • 15 citations

Rate of base substitution in mammalian nuclear DNA is dependent on local sequence context

1987 • 13 citations