UV MUTAGENIC PHOTOPRODUCTS IN Escherichia coli AND HUMAN CELLS: A MOLECULAR GENETICS PERSPECTIVE ON HUMAN SKIN CANCER*

ras GENES

1987 • 3,818 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli

1984 • 1,608 citations

The Wavelengths in Sunlight Effective in Producing Skin Cancer: A Theoretical Analysis

1974 • 1,138 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

1983 • 429 citations

UV-induced mutation hotspots occur at DNA damage hotspots

1982 • 397 citations

Photochemistry and Photobiology of Nucleic Acids

1976 • 374 citations

Radiation-Induced Mutations and Their Repair

1966 • 330 citations

Mutagenic specificity of ultraviolet light

1985 • 282 citations

Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences.

1981 • 252 citations

Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells.

1987 • 242 citations

The specificity of UV-induced mutations at an endogenous locus in mammalian cells.

1987 • 216 citations

Restricted ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum cells.

1986 • 215 citations

A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.

1984 • 192 citations

DNA, light, and Dewar pyrimidinones: the structure and biological significance to TpT3

1987 • 168 citations

Sequence specificity of point mutations induced during passage of a UV-irradiated shuttle vector plasmid in monkey cells.

1986 • 167 citations

DNA mismatch repair-induced double-strand breaks

2007 • 158 citations

UV light-induced cyclobutane pyrimidine dimers are mutagenic in mammalian cells.

1986 • 142 citations

Changes in DNA base sequence induced by targeted mutagenesis of lambda phage by ultraviolet light

1984 • 141 citations

Multiple point mutations in a shuttle vector propagated in human cells: evidence for an error-prone DNA polymerase activity.

1987 • 132 citations

Unique DNA repair properties of a xeroderma pigmentosum revertant.

1987 • 119 citations

Pyrimidine Photodimers

1976 • 119 citations

Properties of ultraviolet-induced rII mutants of bacteriophage T4

1963 • 113 citations

Detection and analysis of UV-induced mutations in mammalian cell DNA using a lambda phage shuttle vector.

1986 • 113 citations

UV irradiation of nucleic acids: formation, purification and solution conformational analysis of the ‘6-4 lesion’ of dTpdT

1985 • 112 citations

Photoreactivation of UV-induced pyrimidine dimers and erythema in the marsupial Monodelphis domestica.

1985 • 111 citations

The C-C (6-4) UV photoproduct is mutagenic in Escherichia coli.

1986 • 101 citations

The lacI shuttle: rapid analysis of the mutagenic specificity of ultraviolet light in human cells.

1985 • 98 citations

Escherichia coli DNA photolyase reverses cyclobutane pyrimidine dimers but not pyrimidine-pyrimidone (6-4) photoproducts.

1985 • 91 citations

Structural determinatlon of the ultraviolet light-induced thymine-cytosine pyrimidine-pyrimidone (6–4) photoproduct

1985 • 88 citations

Identification of the altered bases in mutated single-stranded DNA

1964 • 84 citations

Effect of a single treatment with the alkylating carcinogens dimethylnitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy

1975 • 76 citations

Ultraviolet Radiation-Induced Histopathologic Changes in the Skin of the Marsupial Monodelphis domestica II. Quantitative Studies of the Photoreactivation of Induced Hyperplasia and Sunburn Cell Formation

1985 • 67 citations

THE USE OF SPECIFIC RADIOIMMUNOASSAYS TO DETERMINE ACTION SPECTRA FOR THE PHOTOLYSIS OF (6‐4) PHOTOPRODUCTS

1987 • 67 citations

THE ROLE OF PYRIMIDINE DIMERS AS PREMUTAGENIC LESIONS: A STUDY OF TARGETED VS. UNTARGETED MUTAGENESIS IN THE lacI GENE OF ESCHERICHIA COLI

1984 • 64 citations

Photocarcinogenesis: a review.

1978 • 60 citations

Removal of UV light-induced pyrimidine-pyrimidone(6-4) products from Escherichia coli DNA requires the uvrA, uvrB, and urvC gene products.

1984 • 60 citations

Detection of UV purine photoproducts in a defined sequence of human DNA.

1986 • 51 citations

UV‐CARCINOGENESIS

1984 • 47 citations

The photoreactivity of T-A sequences in oligodeoxyribonucieotides and DNA

1984 • 46 citations

Induction of Pyrimidine Dimers in Epidermal DNA of Hairless Mice by UVB: An Action Spectrum

1983 • 46 citations

UV-induced mutagenesis of phage S13 can occur in the absence of the RecA and UmuC proteins of Escherichia coli.

1985 • 46 citations

Ultraviolet-induced 8,8-adenine dehydrodimers in oligo- and polynucleotides

1986 • 46 citations

Identity of the photoproduct that causes lacI mutations in UV-irradiated Escherichia coli

1985 • 43 citations

The relative cytotoxicity and mutagenicity of cyclobutane pyrimidine dimers and 〈6—4〉 photoproducts in escherichia coli cells

1986 • 39 citations

Oncogenesis: Paradox and paradigm: the message and meaning of myc

1983 • 34 citations

UV light-induced immunoglobulin heavy-chain class switch in a human lymphoblastoid cell line

1983 • 33 citations

Interactive effects of chemical carcinogens and hepatitis B virus in the pathogenesis of hepatocellular carcinoma.

1986 • 32 citations

Dose response, wavelength dependence and rate of excision of ultraviolet radiation-induced pyrimidine dimers in mouse skin DNA

1978 • 29 citations

Enhanced survival and decreased mutation frequency after photoreactivation of UV damage in rat kangaroo cells

1983 • 26 citations

Photoreactivation of Escherichia coli reverses umuC induction by UV light

1985 • 20 citations