The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily 1 1Edited by M. Yaniv

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP

1985 • 39,646 citations

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

1997 • 38,984 citations

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

Multiple sequence alignment with hierarchical clustering

1988 • 5,250 citations

ras GENES

1987 • 3,818 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

1997 • 1,482 citations

WWW-query: An on-line retrieval system for biological sequence banks

1996 • 1,475 citations

Hidden Markov models

1996 • 1,313 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

The structural basis of the activation of Ras by Sos

1998 • 765 citations

The diversity of Rab proteins in vesicle transport

1997 • 762 citations

Protein Prenyltransferases

1996 • 693 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

1995 • 627 citations

The ras protein family: evolutionary tree and role of conserved amino acids

1991 • 573 citations

Structural Basis for Activation of ARF GTPase

1998 • 534 citations

The role of ARF and Rab GTPases in membrane transport

1999 • 496 citations

Rab GTPases coordinate endocytosis

2000 • 447 citations

Wiskott-Aldrich syndrome

1968 • 422 citations

Hypervariable C-termmal domain of rab proteins acts as a targeting signal

1991 • 394 citations

Structural Basis of Rab Effector Specificity

1999 • 347 citations

Structural View of the Ran–Importin β Interaction at 2.3 Å Resolution

1999 • 344 citations

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.

1992 • 323 citations

Rab GTPases, Directors of Vesicle Docking

1998 • 322 citations

Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’ protein

1999 • 319 citations

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

1999 • 308 citations

Structural and Functional Analysis of the ARF1–ARFGAP Complex Reveals a Role for Coatomer in GTP Hydrolysis

1999 • 301 citations

Crystal structures at 2.2 Å resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP

1991 • 261 citations

Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell?

1997 • 219 citations

Role of Rab GTPases in Membrane Traffic

1997 • 217 citations

Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

1998 • 198 citations

Interactions of three domains distinguishing the Ras-related GTP-binding proteins Ypt1 and Sec4

1993 • 190 citations

Structure of the Guanine Nucleotide Exchange Factor Sec7 Domain of Human Arno and Analysis of the Interaction with ARF GTPase

1998 • 184 citations

A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta -phosphate to destabilize GDP on ARF1

1998 • 180 citations

Distinct structural elements of rab5 define its functional specificity.

1994 • 163 citations

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

1999 • 162 citations

Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the ras-family GTPase ran 1 1Edited by I. B. Holland

1998 • 151 citations

Rac “Insert Region” Is a Novel Effector Region That Is Implicated in the Activation of NADPH Oxidase, but Not PAK65

1996 • 151 citations

The Structural Basis of Rho Effector Recognition Revealed by the Crystal Structure of Human RhoA Complexed with the Effector Domain of PKN/PRK1

1999 • 149 citations

Structural basis of activation and GTP hydrolysis in Rab proteins

1999 • 122 citations

The ras superfamily of GTP‐binding proteins: guidelines on nomenclature

1992 • 116 citations

Specificity domains distinguish the Ras-related GTPases Ypt1 and Sec4

1993 • 105 citations

Structural and biochemical analysis of Ras‐effector signaling via RalGDS

1999 • 99 citations

Mutants of Rab3A analogous to oncogenic Ras mutants. Sensitivity to Rab3A-GTPase activating protein and Rab3A-guanine nucleotide releasing factor

1993 • 92 citations

Mutational analysis of the putative effector domain of the GTP-binding Ypt1 protein in yeast suggests specific regulation by a novel GAP activity.

1991 • 91 citations

Amino acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A

1992 • 82 citations

Determination of Interaction Sites on the Small G Protein RhoA for Phospholipase D

1998 • 77 citations

Association of Rab1B with GDP-dissociation Inhibitor (GDI) Is Required for Recycling but Not Initial Membrane Targeting of the Rab Protein

1996 • 70 citations

Residues of the Rho Family GTPases Rho and Cdc42 That Specify Sensitivity to Dbl-like Guanine Nucleotide Exchange Factors

1997 • 68 citations

Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase.

1994 • 65 citations

Distribution and functional diversification of the ras superfamily inSaccharomyces cerevisiae

1998 • 63 citations

Subclass-specific sequence motifs identified in Rab GTPases

1995 • 58 citations

Rab24 Is an Atypical Member of the Rab GTPase Family

2000 • 58 citations

Model of the Ran-RCC1 Interaction using Biochemical and Docking Experiments

1999 • 55 citations

Loop 6 of RhoA Confers Specificity for Effector Binding, Stress Fiber Formation, and Cellular Transformation

1999 • 42 citations

Cloning and Characterization of a NovelRab-Family Gene,Rab36,within the Region at 22q11.2 That Is Homozygously Deleted in Malignant Rhabdoid Tumors

1999 • 40 citations

Isoprenylation of Rab1B is impaired by mutations in its effector domain

1993 • 40 citations

The Rab3A GTPase interacts with multiple factors through the same effector domain. Mutational analysis of cross-linking of Rab3A to a putative target protein.

1993 • 39 citations

Two Novel Human RAB Genes with Near Identical Sequence Each Map to a Telomere-Associated Region: The Subtelomeric Region of 22q13.3 and the Ancestral Telomere Band 2q13

1999 • 38 citations

Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily

1997 • 32 citations

The Putative “Switch 2” Domain of the Ras-related GTPase, Rab1B, Plays an Essential Role in the Interaction with Rab Escort Protein

1998 • 29 citations

Properties of Rab5 N-terminal domain dictate prenylation of C-terminal cysteines.

1995 • 28 citations

Distinct Subclasses of Small GTPases Interact with Guanine Nucleotide Exchange Factors in a Similar Manner

1998 • 27 citations

Construction of a Transcription Map around the Gene for Ataxia Telangiectasia: Identification of at Least Four Novel Genes

1997 • 20 citations

Reversal of Fortune

2000 • 8 citations

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