CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

1980 • 28,067 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

The Neutral Theory of Molecular Evolution

1979 • 7,965 citations

Amino acid substitution matrices from protein blocks.

1992 • 5,998 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

CLUSTAL: a package for performing multiple sequence alignment on a microcomputer

1988 • 3,446 citations

CLUSTAL V: improved software for multiple sequence alignment

1992 • 2,421 citations

Hidden Markov Models in Computational Biology

1994 • 1,954 citations

Progressive sequence alignment as a prerequisitetto correct phylogenetic trees

1987 • 1,899 citations

Detecting Subtle Sequence Signals: a Gibbs Sampling Strategy for Multiple Alignment

1993 • 1,835 citations

Fast and sensitive multiple sequence alignments on a microcomputer

1989 • 1,245 citations

Optimal alignments in linear space

1988 • 1,229 citations

The SWISS-PROT protein sequence data bank

1992 • 530 citations

A tool for multiple sequence alignment.

1989 • 508 citations

Determinants of a protein fold

1987 • 498 citations

A strategy for the rapid multiple alignment of protein sequences

1987 • 482 citations

Crystal structure of a Src-homology 3 (SH3) domain

1992 • 474 citations

Improved sensitivity of profile searches through the use of sequence weights and gap excision

1994 • 301 citations

Pattern-induced multi-sequence alignment (PUMA) algorithm employing secondary structure-dependent gap penalties for use in comparative protein modelling

1992 • 281 citations

SH3 — an abundant protein domain in search of a function

1992 • 280 citations

Comparative biosequence metrics

1981 • 259 citations

Analysis of insertions/deletions in protein structures

1992 • 241 citations

A mutation data matrix for transmembrane proteins

1994 • 213 citations

Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.

1993 • 208 citations

Nucleic acid and protein sequence analysis: a practical approach

1988 • 180 citations

Gap costs for multiple sequence alignment

1989 • 135 citations

Optimal alignment between groups of sequences and its application to multiple sequence alignment

1993 • 130 citations

Improving the sensitivity of the sequence profile method

1994 • 118 citations

Weighting in sequence space: a comparison of methods in terms of generalized sequences.

1993 • 82 citations

Multiple alignment using simulated annealing: branch point definition in human mRNA splicing

1992 • 56 citations

DNA Deletion of Mitochondrial Introns is Correlated with the Process of Senescence in Podospora anserina

1993 • 30 citations