Structural and biochemical analysis of Ras‐effector signaling via RalGDS

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector

1988 • 1,516 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

1995 • 627 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation

1996 • 350 citations

Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor

1996 • 328 citations

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

1994 • 281 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

Structural basis for the interaction of Ras with RaIGDS

1998 • 251 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

Ras/Rap effector specificity determined by charge reversal

1996 • 214 citations

Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.

1993 • 174 citations

Stimulation of gene induction and cell growth by the Ras effector Rlf

1997 • 167 citations

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

1996 • 121 citations

Genes for SMA: Multum in parvo

1995 • 121 citations

Molecular Studies of CtpA, the Carboxyl-terminal Processing Protease for the D1 Protein of the Photosystem II Reaction Center in Higher Plants

1996 • 111 citations

Solution Structure of the Ras-Binding Domain of c-Raf-1 and Identification of Its Ras Interaction Surface

1995 • 109 citations

Interactions between Ras proteins and their effectors

1996 • 82 citations

Identification of a Novel RalGDS-related Protein as a Candidate Effector for Ras and Rap1

1996 • 69 citations

Differential Structural Requirements for Interaction of Ras Protein with Its Distinct Downstream Effectors

1996 • 68 citations

Characterization of Ral GDP Dissociation Stimulator-like (RGL) Activities to Regulate c-fosPromoter and the GDP/GTP Exchange of Ral

1997 • 63 citations

Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1

1997 • 6 citations