Crystal structures at 2.2 Å resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

ras GENES

1987 • 3,818 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Traitement statistique des erreurs dans la determination des structures cristallines

1952 • 1,284 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

1983 • 1,028 citations

The α-helix dipole and the properties of proteins

1978 • 985 citations

THREE-DIMENSIONAL STRUCTURE OF MEMBRANE AND SURFACE PROTEINS

1984 • 959 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

An efficient general-purpose least-squares refinement program for macromolecular structures

1987 • 871 citations

Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

1982 • 706 citations

Solvent accessible surface area and excluded volume in proteins

1984 • 667 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 • 586 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

Structure and activation of the human N-ras gene

1983 • 538 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

1990 • 489 citations

The probability distribution of X-ray intensities

1949 • 406 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.

1985 • 396 citations

Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene

1983 • 385 citations

Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia

1985 • 372 citations

Phosphate‐binding sequences in nucleotide‐binding proteins

1985 • 295 citations

Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus

1982 • 272 citations

Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma virus

1979 • 270 citations

Nucleotide Sequence of the Oncogene Encoding the p21 Transforming Protein of Kirsten Murine Sarcoma Virus

1982 • 256 citations

Mutational analysis of a ras catalytic domain.

1986 • 205 citations

Family of G protein α chains: amphipathic analysis and predicted structure of functional domains

1986 • 197 citations

Activated Proto-onc Genes: Sufficient or Necessary for Cancer?

1985 • 182 citations

Human cancer and cellular oncogenes

1987 • 159 citations

A mutation that alters the nucleotide specificity of elongation factor Tu, a GTP regulatory protein.

1987 • 153 citations

The glycine‐rich loop of adenylate kinase forms a giant anion hole

1986 • 143 citations

Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses.

1982 • 135 citations

The Oncogenic Activation of Human p21 ^ras by a Novel Mechanism

1986 • 130 citations

Structural differences between a ras oncogene protein and the normal protein

1989 • 125 citations

Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080.

1984 • 124 citations

The Mechanism of Guanosine Nucleotide Hydrolysis by p21 c-Ha-ras

1989 • 91 citations

Synthesis and expression of a synthetic gene for the activated human c-Ha-ras protein.

1986 • 83 citations

Characterisation of the metal‐ion–GDP complex at the active sites of transforming and nontransforming p21 proteins by observation of the ¹⁷O‐Mn superhyperfine coupling and by kinetic methods

1987 • 66 citations

Activation of a human c-K-rasoncogeoe

1984 • 44 citations

Conformation of guanosine 5'-diphosphate as bound to a human c-Ha-ras mutant protein: a nuclear Overhauser effect study

1989 • 24 citations

Crystallization of human c-H-ras oncogene products

1988 • 9 citations