Structural Basis of Rab Effector Specificity

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Protein Structure Comparison by Alignment of Distance Matrices

1993 • 3,989 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Aromatic-Aromatic Interaction: A Mechanism of Protein Structure Stabilization

1985 • 2,441 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

1997 • 1,724 citations

[32] GOR method for predicting protein secondary structure from amino acid sequence

1996 • 1,239 citations

Determination of Macromolecular Structures from Anomalous Diffraction of Synchrotron Radiation

1991 • 1,123 citations

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

1998 • 1,101 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

G PROTEIN MECHANISMS: Insights from Structural Analysis

1997 • 1,061 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G _sα ·GTPγS

1997 • 780 citations

The diversity of Rab proteins in vesicle transport

1997 • 762 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

1997 • 673 citations

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

1995 • 627 citations

Stereochemically restrained refinement of macromolecular structures

1985 • 614 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

Structural Basis for Activation of ARF GTPase

1998 • 534 citations

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles

1994 • 501 citations

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.

1990 • 486 citations

The LIM domain is a modular protein-binding interface

1994 • 450 citations

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

1997 • 414 citations

GTPases: Multifunctional Molecular Switches Regulating Vesicular Traffic

1994 • 411 citations

Hypervariable C-termmal domain of rab proteins acts as a targeting signal

1991 • 394 citations

Rabphilin-3A, a Putative Target Protein for smg p25A/rab3A p25 Small GTP-Binding Protein Related to Synaptotagmin

1993 • 386 citations

Torsion angle dynamics: Reduced variable conformational sampling enhances crystallographic structure refinement

1994 • 369 citations

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

1997 • 360 citations

Protein Hydration Observed by X-ray Diffraction

1994 • 343 citations

Defining the functions of trans-SNARE pairs

1998 • 343 citations

Rab GTPases: master regulators of membrane trafficking

1994 • 315 citations

Crystal Structure of the Adenylyl Cyclase Activator G _{s α}

1997 • 310 citations

Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.

1990 • 305 citations

Rab proteins and the road maps for intracellular transport

1993 • 276 citations

RAB3 AND SYNAPTOTAGMIN: The Yin and Yang of Synaptic Membrane Fusion

1998 • 260 citations

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin.

1993 • 253 citations

Structural basis for the interaction of Ras with RaIGDS

1998 • 251 citations

Two Distinct Raf Domains Mediate Interaction with Ras

1995 • 243 citations

Direct Observation of Protein Solvation and Discrete Disorder with Experimental Crystallographic Phases

1996 • 240 citations

Docking of Yeast Vacuoles Is Catalyzed by the Ras-like GTPase Ypt7p after Symmetric Priming by Sec18p (NSF)

1997 • 239 citations

TRANSPORT VESICLE DOCKING: SNAREs and Associates

1996 • 207 citations

The Role of GTP-Binding Proteins in Transport Along the Exocytic Pathway

1993 • 199 citations

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.

1996 • 198 citations

Rab proteins in regulated exocytosis

1994 • 197 citations

Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C

1994 • 197 citations

The effector interactions of p21ras

1993 • 193 citations

Incorporation of Prior Phase Information Strengthens Maximum-Likelihood Structure Refinement

1998 • 190 citations

Interactions of three domains distinguishing the Ras-related GTP-binding proteins Ypt1 and Sec4

1993 • 190 citations

Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target

1993 • 189 citations

Identification of effector-activating residues of Gsα

1992 • 180 citations

C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.

1991 • 169 citations

Histogram matching as a new density modification technique for phase refinement and extension of protein molecules

1990 • 163 citations

Distinct structural elements of rab5 define its functional specificity.

1994 • 163 citations

G proteins, effectors and GAPs: structure and mechanism

1997 • 151 citations

Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras.

1996 • 136 citations

Two functionally different domains of rabphilin-3A, Rab3A p25/smg p25A-binding and phospholipid- and Ca(2+)-binding domains.

1993 • 132 citations

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.

1992 • 132 citations

Phosphorylation of rabphilin-3A by Ca2+/calmodulin- and cAMP-dependent protein kinases in vitro

1995 • 118 citations

Physical and Functional Interaction of Rabphilin-3A with α-Actinin

1996 • 115 citations

The C2 Domains of Rabphilin3A Specifically Bind Phosphatidylinositol 4,5-Bisphosphate Containing Vesicles in a Ca2+-dependent Manner

1998 • 113 citations

Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain.

1990 • 112 citations

A site on rod G protein alpha subunit that mediates effector activation

1992 • 101 citations

Transcriptional Synergy between LIM-Homeodomain Proteins and Basic Helix-Loop-Helix Proteins: the LIM2 Domain Determines Specificity

1997 • 93 citations

Crystallization of a fragment of human fibronectin: Introduction of methionine by site‐directed mutagenesis to allow phasing via selenomethionine

1994 • 90 citations

Noc2, a Putative Zinc Finger Protein Involved in Exocytosis in Endocrine Cells

1997 • 77 citations

The GTPase superfamily

1993 • 75 citations

The enigma of LIM domains

1995 • 72 citations

The use of anomalous scattering effects to phase diffraction patterns from macromolecules

1980 • 69 citations

Structure of the Cysteine-Rich Intestinal Protein, CRIP

1996 • 64 citations

Role of the Rab3A-Binding Domain in Targeting of Rabphilin-3A to Vesicle Membranes of PC12 Cells

1996 • 52 citations

rab3 Mediates Cortical Granule Exocytosis in the Sea Urchin Egg

1998 • 44 citations

LIM domains of cysteine-rich protein 1 (CRP1) are essential for its zyxin-binding function

1998 • 37 citations

Phosphorylation of Rabphilin-3A by Calmodulin-Dependent Protein Kinase II

1994 • 29 citations

Rab7: NMR and kinetics analysis of intact and C-terminal truncated constructs

1997 • 18 citations