Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Basic local alignment search tool

1990 • 87,358 citations

Random sample consensus

1981 • 23,215 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

Identification of common molecular subsequences

1981 • 9,753 citations

Amino acid substitution matrices from protein blocks.

1992 • 5,998 citations

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

Least-Squares Fitting of Two 3-D Point Sets

1987 • 3,657 citations

Sequence Analysis of the Genome of the Unicellular Cyanobacterium Synechocystis sp. Strain PCC6803. II. Sequence Determination of the Entire Genome and Assignment of Potential Protein-coding Regions (Supplement)

1996 • 2,455 citations

Atlas of Protein Sequence and Structure, 1972.

1973 • 2,408 citations

Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii

1996 • 2,043 citations

Time Warps, String Edits, and Macromolecules: The Theory and Practice of Sequence Comparison

1983 • 1,947 citations

Detecting Subtle Sequence Signals: a Gibbs Sampling Strategy for Multiple Alignment

1993 • 1,835 citations

An improved algorithm for matching biological sequences

1982 • 1,728 citations

Database of homology‐derived protein structures and the structural meaning of sequence alignment

1991 • 1,641 citations

Rapid similarity searches of nucleic acid and protein data banks.

1983 • 1,577 citations

Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes.

1990 • 1,542 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

Atlas of Protein Sequence and Structure, 1966.

1967 • 1,463 citations

Profile analysis: detection of distantly related proteins.

1987 • 1,308 citations

Optimal alignments in linear space

1988 • 1,229 citations

The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers

1996 • 1,008 citations

Information content of binding sites on nucleotide sequences

1986 • 953 citations

Issues in searching molecular sequence databases

1994 • 781 citations

Selection of DNA binding sites by regulatory proteins

1987 • 761 citations

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

1997 • 750 citations

Statistics of local complexity in amino acid sequences and sequence databases

1993 • 735 citations

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

1996 • 734 citations

[27] Local alignment statistics

1996 • 729 citations

The SWISS-PROT protein sequence data bank and its supplement TrEMBL

1997 • 709 citations

Computer methods to locate signals in nucleic acid sequences

1984 • 673 citations

Amino acid substitution matrices from an information theoretic perspective

1991 • 637 citations

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

1997 • 525 citations

Identifying protein-binding sites from unaligned DNA fragments.

1989 • 471 citations

Position-based sequence weights

1994 • 422 citations

Applications and statistics for multiple high-scoring segments in molecular sequences.

1993 • 372 citations

Dirichlet mixtures: a method for improved detection of weak but significant protein sequence homology

1996 • 338 citations

A flexible motif search technique based on generalized profiles

1996 • 306 citations

Improved sensitivity of profile searches through the use of sequence weights and gap excision

1994 • 301 citations

A new algorithm for best subsequence alignments with application to tRNA-rRNA comparisons

1987 • 293 citations

Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks.

1994 • 286 citations

Identification of protein sequence homology by consensus template alignment

1986 • 283 citations

Maximum Discrimination Hidden Markov Models of Sequence Consensus

1995 • 248 citations

Prediction of the Coding Sequences of Unidentified Human Genes. VI. The Coding Sequences of 80 New Genes (KIAA0201-KIAA0280) Deduced by Analysis of cDNA Clones from Cell Line KG-1 and Brain

1996 • 230 citations

Optimal sequence alignments

1983 • 226 citations

Complete structure of the hemagglutinin gene from the human influenza A/Victoria/3/75 (H3N2) strain as determined from cloned DNA

1980 • 225 citations

Optimal sequence alignment using affine gap costs

1986 • 222 citations

The statistical distribution of nucleic acid similarities

1985 • 206 citations

Systematic method for the detection of potential λ Cro-like DNA-binding regions in proteins

1987 • 191 citations

Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development.

1996 • 184 citations

Weights for data related by a tree

1989 • 182 citations

Volume changes in protein evolution

1994 • 181 citations

Using Dirichlet mixture priors to derive hidden Markov models for protein families.

1993 • 170 citations

GenBank

1997 • 166 citations

Using substitution probabilities to improve position-specific scoring matrices

1996 • 165 citations

Detecting homology of distantly related proteins with consensus sequences

1987 • 155 citations

Limit Distribution of Maximal Non-Aligned Two-Sequence Segmental Score

1994 • 154 citations

Aligning two sequences within a specified diagonal band

1992 • 153 citations

A protein alignment scoring system sensitive at all evolutionary distances

1993 • 151 citations

Distribution of glutamine and asparagine residues and their near neighbors in peptides and proteins.

1991 • 128 citations

A Workbench for large-scale sequence homology analysis

1994 • 121 citations

Maximum-likelihood estimation of the statistical distribution of Smith-Waterman local sequence similarity scores

1992 • 110 citations

The significance of protein sequence similarities

1988 • 100 citations

Weighting aligned protein or nucleic acid sequences to correct for unequal representation

1990 • 95 citations

Embedding strategies for effective use of information from multiple sequence alignments

1997 • 81 citations

Pattern recognition in genetic sequences by mismatch density

1984 • 77 citations

Proceedings of the Fourth International Conference on Intelligent Systems for Molecular Biology

1996 • 76 citations

Proceedings Of The Third International Conference On Intelligent Systems For Molecular Biology

1995 • 75 citations

Analysis of gene duplication repeats in the myosin rod

1983 • 70 citations

A weighting system and aigorithm for aligning many phylogenetically related sequences

1995 • 65 citations

New structure — novel fold?

1997 • 64 citations

Theoretical and Computational Methods in Genome Research

1997 • 59 citations

Recognition of related proteins by iterative template refinement (ITR)

1994 • 46 citations

Locally optimal subalignments using nonlinear similarity functions

1986 • 44 citations

The gal locus from Haemophilus influenzae: cloning, sequencing and the use of gal mutants to study lipopolysaccharide

1992 • 42 citations

The amino acid sequence of leghaemoglobin I from root nodules of broad bean (Vicia faba L.)

1975 • 38 citations

Sequence analysis in the E1 region of adenovirus type 4 DNA

1986 • 32 citations

Locally optimal subalignments using nonlinear similarity functions

1986 • 32 citations

Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase

1989 • 31 citations

Rat galactose-1-phosphate uridyltransferase coding sequence, transcription start site and genomic organization

1993 • 9 citations

[Hemoglobins, XXXIII. Note on the Sequence of the hemoglobins of the horse (author's transl)].

1980 • 5 citations