Natural and Engineered Disorders of Lymphocyte Development

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio

1996 • 1,633 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

1994 • 1,053 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

1997 • 792 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 • 726 citations

Failure of B-cell differentiation in mice lacking the transcription factor EBF

1995 • 667 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

New member of the winged-helix protein family disrupted in mouse and rat nude mutations

1994 • 651 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1995 • 566 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection

1995 • 437 citations

The role of Hoxa-3 in mouse thymus and thyroid development

1995 • 421 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.

1996 • 382 citations

The CD19–CD21 Complex Regulates Signal Transduction Thresholds Governing Humoral Immunity and Autoimmunity

1997 • 379 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

Homozygous Human TAP Peptide Transporter Mutation in HLA Class I Deficiency

1994 • 348 citations

Redundant Regulation of T Cell Differentiation and TCRα Gene Expression by the Transcription Factors LEF-1 and TCF-1

1998 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Impaired expansion of mouse B cell progenitors lacking Btk

1995 • 314 citations

Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene

1995 • 313 citations

Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ

1996 • 294 citations

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

1996 • 286 citations

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1997 • 285 citations

Atypical X-Linked Severe Combined Immunodeficiency Due to Possible Spontaneous Reversion of the Genetic Defect in T Cells

1996 • 276 citations

Mutations in the Human λ5/14.1 Gene Result in B Cell Deficiency and Agammaglobulinemia

1998 • 275 citations

Thinking about genetic redundancy

1993 • 244 citations

Cell-Autonomous Defects in Dendritic Cell Populations of Ikaros Mutant Mice Point to a Developmental Relationship with the Lymphoid Lineage

1997 • 221 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

Fyn Can Partially Substitute for Lck in T Lymphocyte Development

1996 • 213 citations

CD3delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

1997 • 209 citations

Function of the TCRα Enhancer in αβ and γδ T Cells

1997 • 204 citations

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

1997 • 195 citations

Lymphoid Hyperplasia, Autoimmunity, and Compromised Intestinal Intraepithelial Lymphocyte Development in Colitis-Free Gnotobiotic IL-2-Deficient Mice

1998 • 180 citations

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

1993 • 164 citations

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

1996 • 164 citations

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1997 • 159 citations

NATURALLY OCCURRING PRIMARY DEFICIENCIES OF THE IMMUNE SYSTEM

1997 • 159 citations

Restoration of lymphocyte function in Janus Kinase 3-deficient mice by retroviral-mediated gene transfer

1998 • 143 citations

A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice

1996 • 142 citations

Independent mutations of the human CD3–ε gene resulting in a T cell receptor/CD3 complex immunodeficiency

1993 • 125 citations

Role of the Multiple T Cell Receptor (TCR)-ζ Chain Signaling Motifs in Selection of the T Cell Repertoire

1997 • 116 citations

The Interferon Regulatory Transcription Factor IRF-1 Controls Positive and Negative Selection of CD8+ Thymocytes

1997 • 112 citations

Surrogate Light Chain in B Cell Development

1996 • 110 citations

CD40Lbase: a database of CD40L gene mutations causing X-linked hyper-IgM syndrome

1996 • 109 citations

Role of Different T Cell Receptors in the Development of Pre–T Cells

1997 • 108 citations

DiGeorge syndrome: an historical review of clinical and cytogenetic features.

1993 • 106 citations

Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8

1993 • 101 citations

A Spontaneously Arising Mutation in the DLAARN Motif of Murine ZAP-70 Abrogates Kinase Activity and Arrests Thymocyte Development

1997 • 81 citations

Subunit Composition of Pre–T Cell Receptor Complexes Expressed by Primary Thymocytes: CD3δ Is Physically Associated but Not Functionally Required

1997 • 80 citations

Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.

1996 • 73 citations

Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development.

1996 • 72 citations

CD40Lbase: a database of CD40L gene mutations causing X-linked hyper-IgM syndrome

1996 • 64 citations

Two Distinct Steps during Thymocyte Maturation from CD4−CD8− to CD4+CD8+ Distinguished in the Early Growth Response (Egr)-1 Transgenic Mice with a Recombinase-activating Gene–Deficient Background

1997 • 62 citations

Restoration of Thymocyte Development and Function in zap-70−/− Mice by the Syk Protein Tyrosine Kinase

1997 • 57 citations

Severe combined immunodeficiency (SCID) in man: B cell-negative (B-) SCID patients exhibit an irregular recombination pattern at the JH locus.

1991 • 52 citations

Lack of detectable defect in DNA double-strand break repair and DNA-dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts

1996 • 51 citations

Exit of the Pre-TCR from the ER/cis-Golgi Is Necessary for Signaling Differentiation, Proliferation, and Allelic Exclusion in Immature Thymocytes

1997 • 51 citations

The CD3-γδε and CD3-ζ/η Modules Are Each Essential for Allelic Exclusion at the T Cell Receptor β Locus but Are Both Dispensable for the Initiation of V to (D)J Recombination at the T Cell Receptor–β, –γ, and –δ Loci

1998 • 47 citations

BTKbase: XLA-mutation registry

1996 • 46 citations

Domains of the TCR beta-chain required for early thymocyte development.

1996 • 30 citations

BTKbase: XLA-mutation registry

1996 • 25 citations

Making the in-vitro model closer to actual B lymphopoiesis in the bone marrow

1995 • 7 citations