Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

1988 • 1,180 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation.

1994 • 334 citations

VDJ recombination

1992 • 307 citations

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1994 • 267 citations

Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells.

1994 • 258 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

1993 • 219 citations

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

1993 • 190 citations

Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element.

1988 • 185 citations

Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

1992 • 181 citations

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.

1993 • 168 citations

TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events.

1993 • 132 citations

A Transcriptional Enhancer 3′ of C _β2 in the T Cell Receptor β Locus

1988 • 118 citations

Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene.

1994 • 85 citations

Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells.

1994 • 85 citations

A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.

1993 • 81 citations

Mechanisms that control antigen receptor variable region gene assembly

1994 • 35 citations

Promotion of V(D)J recombinational accessibility by the intronic Ek element: role of the κB motif

1995 • 31 citations

A V(D)J Recombinase-Inducible B-Cell Line: Role of Transcriptional Enhancer Elements in Directing V(D)J Recombination

1993 • 29 citations