Cell-Autonomous Defects in Dendritic Cell Populations of Ikaros Mutant Mice Point to a Developmental Relationship with the Lymphoid Lineage

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.

1992 • 642 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes.

1997 • 524 citations

Ikaros, an Early Lymphoid-Specific Transcription Factor and a Putative Mediator for T Cell Commitment

1992 • 458 citations

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

1996 • 405 citations

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.

1996 • 379 citations

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

1997 • 360 citations

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1991 • 343 citations

Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha.

1995 • 296 citations

Developmental potential of the earliest precursor cells from the adult mouse thymus.

1991 • 294 citations

Dendritic Cell Development in Culture from Thymic Precursor Cells in the Absence of Granulocyte/Macrophage Colony-stimulating Factor

1996 • 265 citations

The influence of granulocyte/macrophage colony‐stimulating factor on dendritic cell levels in mouse lymphoid organs

1997 • 247 citations

Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation.

1993 • 233 citations

The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene.

1994 • 225 citations

The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse.

1996 • 171 citations

T-cell lineage commitment and cytokine responses of thymic progenitors

1995 • 164 citations

Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation

1995 • 138 citations

Requirement for TNF-α and IL-1α in Fetal Thymocyte Commitment and Differentiation

1995 • 135 citations

In Vitro Regulation of Dendritic Cell Development and Function

1996 • 37 citations

CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells

1996 • 36 citations