The CD19–CD21 Complex Regulates Signal Transduction Thresholds Governing Humoral Immunity and Autoimmunity

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

1996 • 1,172 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.

1984 • 936 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

CD19: Lowering the Threshold for Antigen Receptor Stimulation of B Lymphocytes

1992 • 673 citations

Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization.

1982 • 665 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule

1995 • 546 citations

Hyperresponsive B Cells in CD22-Deficient Mice

1996 • 530 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity.

1995 • 496 citations

Disruption of the Cr2 Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent Antigen

1996 • 494 citations

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

1996 • 477 citations

The CD19/CR2/TAPA-1 Complex of B Lymphocytes: Linking Natural to Acquired Immunity

1995 • 469 citations

Structure and Function of the Complement Receptors, CR1 (CD35) and CR2 (CD21)

1989 • 460 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

CD22 Is Both a Positive and Negative Regulator of B Lymphocyte Antigen Receptor Signal Transduction: Altered Signaling in CD22-Deficient Mice

1996 • 437 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.

1992 • 400 citations

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection

1995 • 394 citations

Regulation of the B cell response to T-dependent antigens by classical pathway complement.

1996 • 369 citations

TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins.

1990 • 365 citations

Transgenic Mice and Analysis of B-Cell Tolerance

1992 • 362 citations

ROLE OF COMPLEMENT IN INDUCTION OF ANTIBODY PRODUCTION IN VIVO

1974 • 357 citations

Identification and characterization of the Epstein-Barr virus receptor on human B lymphocytes and its relationship to the C3d complement receptor (CR2)

1985 • 343 citations

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.

1994 • 340 citations

CD19 of B Cells as a Surrogate Kinase Insert Region to Bind Phosphatidylinositol 3-Kinase

1993 • 320 citations

Peritoneal Ly‐1 B cells: Genetic control, autoantibody production, increased lambda light chain expression

1986 • 306 citations

Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.

1991 • 301 citations

CD22, A B LYMPHOCYTE–SPECIFIC ADHESION MOLECULE THAT REGULATES ANTIGEN RECEPTOR SIGNALING^*

1997 • 296 citations

Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody.

1984 • 263 citations

CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity.

1996 • 263 citations

The CD19/CD21 signal transduction complex of B lymphocytes

1994 • 254 citations

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.

1993 • 243 citations

Suppression of the Immune Response by a Soluble Complement Receptor of B Lymphocytes

1991 • 242 citations

Growth control of activated, synchronized murine B cells by the C3d fragment of human complement

1985 • 238 citations

Antibody response to a T-dependent antigen requires B cell expression of complement receptors.

1996 • 236 citations

The generation of memory cells. I. The role of C3 in the generation of B memory cells.

1977 • 235 citations

Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling.

1992 • 212 citations

Complement Dependence of Localisation of Aggregated IgG in Germinal Centres

1975 • 210 citations

In vivo inhibition of the antibody response by a complement receptor-specific monoclonal antibody.

1990 • 205 citations

The development and repertoire of B-1 cells (CD5 B cells)

1991 • 198 citations

Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.

1989 • 195 citations

Molecular analysis of a human interferon‐inducible gene family

1991 • 186 citations

Role of Complement in Induction of the Allergic Response

1972 • 179 citations

A molecular and immunochemical characterization of mouse CR2. Evidence for a single gene model of mouse complement receptors 1 and 2.

1990 • 166 citations

Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes.

1987 • 160 citations

Bound C3 as the second signal for B-cell activation

1973 • 158 citations

The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation.

1995 • 158 citations

Expression Cloning of an Interferon-inducible 17-kDa Membrane Protein Implicated in the Control of Cell Growth

1995 • 157 citations

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice.

1996 • 152 citations

TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen.

1990 • 149 citations

CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19.

1997 • 148 citations

Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors.

1994 • 147 citations

B-1 cells are made, not born

1993 • 141 citations

Clonal Deletion of Autospecific B Lymphocytes

1991 • 137 citations

Self‐renewal of B‐1 lymphocytes is dependent on CD19

1996 • 132 citations

Tissue-Specific Expression of the Human CD 19 Gene in Transgenic Mice Inhibits Antigen-Independent B-Lymphocyte Development

1994 • 131 citations

Distinctive Developmental Origins and Specificities of Murine CD5⁺ B Cells

1994 • 129 citations

Role of Complement in the Induction of Immunological Responses

1976 • 124 citations

Immune Response of a Patient with Deficiency of the Fourth Component of Complement and Systemic Lupus Erythematosus

1979 • 119 citations

Signal transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogeny.

1993 • 115 citations

The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13.

1993 • 111 citations

Involvement of B-1 cells in mucosal immunity and autoimmunity

1995 • 111 citations

Effects of Anti‐Ig Antibodies on the Development and Differentiation of B Cells

1980 • 110 citations

Characterization of human T lymphocytes that express the C3b receptor.

1983 • 109 citations

Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex.

1991 • 101 citations

The role of complement in the induction of antibody responses.

1983 • 96 citations

Antibodies to murine complement receptor 1 and 2 can inhibit the antibody response in vivo without inhibiting T helper cell induction.

1995 • 94 citations

Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain.

1991 • 93 citations

Role of C3 in humoral immunity. Defective antibody production in C3-deficient dogs.

1988 • 91 citations

The CR2/CD19 complex on human B cells contains the src-family kinase Lyn

1993 • 85 citations

Tyrosine phosphorylation of CD19 in pre-B and mature B cells.

1993 • 84 citations

Expression of C3b receptors on human be cells and myelomonocytic cells but not natural killer cells.

1983 • 83 citations

Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development.

1994 • 83 citations

Influence of genetically inherited complement deficiencies on humoral immune response in guinea pigs.

1985 • 80 citations

Dual antigen recognition by B cells

1993 • 79 citations

Clinical Expression of Systemic Lupus Erythematosus in Patients with C4A Deficiency

1993 • 78 citations

Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice.

1993 • 78 citations

Structure and membrane topology of TAPA-1

1991 • 71 citations

Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement.

1986 • 71 citations

CD5+ B cells in autoimmune disease and lymphoid malignancy

1991 • 67 citations

Deficiency of the Effector Mechanisms of the Immune Response and Autoimmunity

2007 • 58 citations

Co‐ligation of mouse complement receptors 1 and 2 with surface IgM rescues splenic B cells and WEHI‐231 cells from anti‐surface IgM‐induced apoptosis

1995 • 56 citations

Development and Function of the Early B Cell Repertoire

1992 • 55 citations

Inhibition of immunological memory and T‐independent humoral responses by monoclonal antibodies specific for murine complement receptors

1991 • 55 citations

Specific binding of Fyn and phosphatidylinositol 3‐kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains

1995 • 54 citations

Structural differences between the two human complement C4 isotypes affect the humoral immune response.

1992 • 42 citations

Inhibition of B cell proliferation with anti‐CD19 monoclonal antibodies: anti‐CD19 antibodies do not interfere with early signaling events triggered by anti‐IgM or interleukin 4

1991 • 36 citations

Antigen-binding repertoire and Ig H chain gene usage among B cell hybridomas from normal and autoimmune mice.

1990 • 27 citations

Natural murine autoantibodies and conventional antibodies exhibit similar degrees of antigenic cross-reactivity.

1988 • 25 citations

Cell cycle control of activated, synchronized murine B lymphocytes—roles of macrophages and complement C3

1986 • 14 citations

The structure of an alternate form of complement C3 that displays costimulatory growth factor activity for B lymphocytes.

1994 • 11 citations

SYSTEMIC LUPUS ERYTHEMATOSUS

2023 • 11 citations

Deleted Work

1955 • 0 citations