Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981 • 5,629 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

1985 • 978 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

A monoclonal antibody discriminating between subsets of T and B cells.

1981 • 565 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

A novel population of T-cell receptor αβ-bearing thymocytes which predominantly expresses a single Vβ gene family

1987 • 397 citations

Molecular Biology and Function of CD4 and CD8

1989 • 388 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function.

1989 • 356 citations

Genes of the T-Cell Antigen Receptor in Normal and Malignant T Cells

1987 • 321 citations

Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.

1987 • 230 citations

Expression and functional significance of the J11d marker on mouse thymocytes.

1987 • 218 citations

Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.

1985 • 191 citations

An unusual lineage of alpha/beta T cells that contains autoreactive cells.

1991 • 152 citations

Skin graft rejection by beta 2-microglobulin-deficient mice.

1992 • 142 citations

The T cell repertoire may be biased in favor of MHC recognition

1986 • 121 citations

Molecular Interactions, T‐Cell Subsets and a Role of the CD4/CD8:p56^lck Complex in Human T‐Cell Activation

1989 • 118 citations

Selecting T Cell Receptors with High Affinity for Self-MHC by Decreasing the Contribution of CD8

1992 • 98 citations

Development of CD4−CD8+ cytotoxic T cells requires interactions with class I MHC determinants

1988 • 76 citations

Engagement of CD4 and CD8 accessory molecules is required for T cell maturation.

1989 • 70 citations

CD8 is required during positive selection of CD4-/CD8+ T cells.

1990 • 65 citations

T cell antigen receptor expression by subsets of Ly-2-L3T4- (CD8-CD4-) thymocytes.

1988 • 51 citations

Distinctive selection mechanisms govern the T cell receptor repertoire of peripheral CD4-CD8- alpha/beta T cells.

1992 • 43 citations

Characterization of an Lyt-2+ alloreactive cytotoxic T cell clone specific for H-2Db that cross-reacts with I-Ek.

1986 • 35 citations

CD4-CD8- T cell receptor alpha beta T cells: generation of an in vitro major histocompatibility complex class I specific cytotoxic T lymphocyte response and allogeneic tumor rejection.

1991 • 33 citations

COMPARISON OF ALLOGENEIC AND XENOGENEIC DETERMINANTS ON THE H-2Kk MOLECULE

1983 • 27 citations

Mechanism of skin allograft enhancement across an H‐2 class I mutant difference. Evidence for involvement of veto cells

1988 • 23 citations