Severe combined immunodeficiency (SCID) in man: B cell-negative (B-) SCID patients exhibit an irregular recombination pattern at the JH locus.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

The Primary Immunodeficiencies

1984 • 1,111 citations

Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

1981 • 959 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

1989 • 572 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

The scid mutation in mice causes a general defect in DNA repair

1990 • 525 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

1988 • 441 citations

Regulation of Genome Rearrangement Events during Lymphocyte Differentiation

1986 • 422 citations

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

1990 • 414 citations

Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes.

1991 • 364 citations

Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes

1981 • 327 citations

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1988 • 306 citations

Biochemistry of Diseases of Immunodevelopment

1981 • 242 citations

Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.

1988 • 174 citations

Severe Combined Immunodeficiency Due to a Specific Defect in the Production of Interleukin-2

1990 • 146 citations

MECHANISM AND DEVELOPMENTAL PROGRAM OF IMMUNOGLOBULIN GENE REARRANGEMENT IN MAMMALS

1989 • 144 citations

Combined immunodeficiency disease associated with absence of cell-surface HLA-A and -B antigens

1978 • 134 citations

Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.

1989 • 128 citations

Cloning of human immunoglobulin μ gene and comparison with mouse μ gene

1980 • 124 citations

The mouse mutation severe combined immune deficiency (scid) is on chromosome 16

1989 • 113 citations

The mechanism of antigen receptor gene assembly

1989 • 108 citations

The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement.

1988 • 94 citations

A defect in the regulation of major histocompatibility complex class II gene expression in human HLA-DR negative lymphocytes from patients with combined immunodeficiency syndrome.

1985 • 86 citations

Improved yields of long PCR products using gene 32 protein

1990 • 82 citations

Absence of interleukin 2 production in a severe combined immunodeficiency disease syndrome with T cells.

1990 • 78 citations

Selective defect of precursor T cells associated with apparently normal B lymphocytes in severe combined immunodeficiency disease

1978 • 71 citations

Aberrant immunoglobulin gene rearrangement in scid mouse bone marrow cells.

1988 • 65 citations

Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice.

1988 • 55 citations

Limited T cell receptor diversity of transplacentally acquired maternal T cells in severe combined immunodeficiency.

1991 • 48 citations

T-cell receptor delta gene recombination in common acute lymphoblastic leukemia: preferential usage of V delta 2 and frequent involvement of the J alpha cluster

1991 • 45 citations

Defective V‐to‐J recombination of T cell receptor γ chain genes in scid mice

1990 • 35 citations

Immunodeficiency with defective T-cell response to interleukin 1.

1984 • 27 citations

Unusual immunoglobulin DNA sequences from the nonexpressed chromosome of mouse normal B lymphocytes: implications for allelic exclusion and the DNA rearrangement process.

1987 • 18 citations

Abnormalities in DNA rearrangements of immunoglobulin gene loci in precursor B cells derived from X-linked agammaglobulinemia patient and a severe combined immunodeficiency patient

1988 • 17 citations