Neuronal nicotinic receptors: Molecular organization and regulations

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Allosteric proteins and cellular control systems

1963 • 2,187 citations

GABA_A Receptor Channels

1994 • 1,948 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 1,676 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

1993 • 1,455 citations

The Time Course of Glutamate in the Synaptic Cleft

1992 • 1,071 citations

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB

1990 • 1,061 citations

Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat

1989 • 1,049 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin

1985 • 1,037 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1990 • 923 citations

Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system

1990 • 872 citations

α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

1994 • 869 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Neurotransmitters as growth regulatory signals: role of receptors and second messengers

1993 • 806 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription

1986 • 761 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

Neuropeptides in perspective: The last ten years

1991 • 620 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1989 • 615 citations

Acetylcholine Binding by a Synthetic Receptor: Implications for Biological Recognition

1990 • 608 citations

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1980 • 608 citations

Regulation of growth cone behavior by calcium

1991 • 597 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

On the reaction of cells and of nerve‐endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari

1905 • 581 citations

Phosphocholine binding immunoglobulin Fab McPC603

1986 • 576 citations

Use of a Snake Venom Toxin to Characterize the Cholinergic Receptor Protein

1970 • 575 citations

Evidence that Tobacco Smoking Increases the Density of (−)‐[³H]Nicotine Binding Sites in Human Brain

1988 • 554 citations

Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors

1991 • 552 citations

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes.

1993 • 543 citations

Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment

1992 • 540 citations

Primary structures of β- and δ-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences

1983 • 527 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1990 • 514 citations

Nicotinic Cholinergic Receptor Binding Sites in the Brain: Regulation in Vivo

1983 • 478 citations

Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis

1986 • 472 citations

Brain α-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily

1990 • 471 citations

Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors

1992 • 465 citations

Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor

1991 • 463 citations

Glutamate receptor desensitization and its role in synaptic transmission

1989 • 459 citations

Acetylcholine Receptors in Muscle Fibres

1971 • 443 citations

Transmitter leakage from motor nerve endings

1977 • 443 citations

Regulation of neurotransmitter receptor desensitization by protein phosphorylation

1990 • 439 citations

ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES

1967 • 439 citations

Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices.

1992 • 435 citations

Cloning and sequence analysis of calf cDNA and human genomic DNA encoding α-subunit precursor of muscle acetylcholine receptor

1983 • 433 citations

On the application of “a plausible model” of allosteric proteins to the receptor for acetylcholine

1967 • 425 citations

Molecular evolution of the nicotinic acetylcholine receptor: An example of multigene family in excitable cells

1995 • 422 citations

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic

1992 • 420 citations

Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit.

1983 • 412 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor.

1993 • 389 citations

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1978 • 384 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Nicotinic receptor of acetylcholine: structure of an oligomeric integral membrane protein

1984 • 373 citations

Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues.

1986 • 361 citations

The paradox of nicotinic acetylcholine receptor upregulation by nicotine

1990 • 350 citations

Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems

1995 • 338 citations

Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain.

1983 • 332 citations

Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.

1985 • 330 citations

Calcium influx through nicotinic receptor in rat central neurons: Its relevance to cellular regulation

1992 • 328 citations

Functional Architecture of the Nicotinic Acetylcholine Receptor: From Electric Organ to Brain

1991 • 327 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure

1991 • 313 citations

Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes

1986 • 312 citations

Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes

1993 • 303 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.

1986 • 296 citations

Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells.

1979 • 295 citations

Quaternary structure of the acetylcholine receptor

1985 • 281 citations

Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

1989 • 279 citations

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1990 • 275 citations

Progesterone modulates a neuronal nicotinic acetylcholine receptor.

1992 • 272 citations

d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor.

1990 • 256 citations

Evidence for "preterminal" nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus

1993 • 255 citations

Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels

1994 • 254 citations

Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from Torpedo marmorata

1983 • 250 citations

Cholinergic inhibition of short (outer) hair cells of the chick's cochlea.

1992 • 249 citations

Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways.

1987 • 247 citations

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.

1990 • 247 citations

Neuronal acetylcholine receptors that bind alpha-bungarotoxin mediate neurite retraction in a calcium-dependent manner

1994 • 246 citations

Nicotinic and muscarinic modulations of excitatory synaptic transmission in the rat prefrontal cortexin vitro

1993 • 244 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

The Feedback Control Mechanism of Biosynthetic L-Threonine Deaminase by L-Isoleucine

1961 • 243 citations

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.

1992 • 238 citations

Presynaptic Nicotinic Cholinergic Receptors Labeled by [³H]Acetylcholine on Catecholamine and Serotonin Axons in Brain

1984 • 235 citations

Structure of nicotinic acetylcholine receptors

1993 • 234 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

Nicotinic Antagonists Enhance Process Outgrowth by Rat Retinal Ganglion Cells in Culture

1988 • 226 citations

Neurotoxins Distinguish Between Different Neuronal Nicotinic Acetylcholine Receptor Subunit Combinations

1990 • 225 citations

Chapter 4 Coexistence of neuronal messengers — an overview

1986 • 223 citations

Immunocytochemical localization of a neuronal nicotinic receptor: the beta 2-subunit

1993 • 222 citations

Acetylcholine receptor gene expression at the developing neuromuscular junction.

1995 • 215 citations

Effect of nicotine and other drugs on the release of 3H-norepinephrine and 3H-dopamine from rat brain slices

1974 • 214 citations

Cholinergic inhibition of short (outer) hair cells of the chick's cochlea

1992 • 212 citations

Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata

1973 • 212 citations

Stereoselective Nicotine‐Induced Release of Dopamine from Striatal Synaptosomes: Concentration Dependence and Repetitive Stimulation

1988 • 209 citations

Calcitonin gene-related peptide enhances the rate of desensitization of the nicotinic acetylcholine receptor in cultured mouse muscle cells.

1988 • 208 citations

The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain

1992 • 205 citations

Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression

1993 • 205 citations

The neurobiology of tobacco addiction

1991 • 200 citations

Desensitization of the nicotinic acetylcholine receptor: Molecular mechanisms and effect of modulators

1989 • 198 citations

Neurotransmitter-gated ion channels as unconventional allosteric proteins

1994 • 197 citations

Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities.

1990 • 193 citations

Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo-interpeduncular system

1991 • 193 citations

Potentiation of nicotinic receptor response by external calcium in rat central neurons

1992 • 191 citations

Alpha 5, alpha 3, and non-alpha 3. Three clustered avian genes encoding neuronal nicotinic acetylcholine receptor-related subunits.

1990 • 191 citations

Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels

1992 • 191 citations

Progress in the purification of the cholinergic receptor protein from Electrophorus electricus by affinity chromatography

1972 • 186 citations

Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity.

1993 • 186 citations

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

1991 • 184 citations

Purification and characterization of a polypeptide from chick brain that promotes the accumulation of acetylcholine receptors in chick myotubes.

1986 • 184 citations

Fast Kinetic Studies on the Interaction of a Fluorescent Agonist with the Membrane‐Bound Acetylcholine Receptor from Torpedo marmorata

1979 • 183 citations

Nicotinic effect of acetylcholine on the release of newly synthesized [3H]dopamine in rat striatal slices and cat caudate nucleus

1976 • 180 citations

A study of curare action with an electrical micro-method

1957 • 180 citations

Allosteric modulations of the nicotinic acetylcholine receptor

1993 • 179 citations

Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. I. Binding of the tritiated alpha-neurotoxin in the absence of effector.

1974 • 170 citations

Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times

1980 • 170 citations

An Analog of Lophotoxin Reacts Covalently with Tyr190 in the α-Subunit of the Nicotinic Acetylcholine Receptor

1989 • 169 citations

Volume Transmission in the Brain

1992 • 169 citations

Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site‐directed mutagenesis

1991 • 168 citations

Functional architecture of the nicotinic acetylcholine receptor: A prototype of ligand-gated ion channels

1993 • 168 citations

Arrangement of the acetylcholine receptor subunits in the resting and desensitized states, determined by cryoelectron microscopy of crystallized Torpedo postsynaptic membranes.

1988 • 167 citations

Purification and characterization of a nicotinic acetylcholine receptor from chick brain

1986 • 167 citations

Functional Contribution of Neuronal AChR Subunits Revealed by Antisense Oligonucleotides

1991 • 164 citations

Das Sauerstoff-Bedürfniss des Organismus

2013 • 164 citations

The expression of nicotinic acetylcholine receptors by PC12 cells treated with NGF

1992 • 163 citations

Spontaneous openings of the acetylcholine receptor channel.

1984 • 162 citations

Structure and function of inhibitory glycine receptors

1992 • 162 citations

Purification fromTorpedo marmorata electric tissue of membrane fragments particularly rich in cholinergic receptor protein

1972 • 160 citations

Nicotine receptors in the mammalian brain

1990 • 149 citations

Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. II. Effect of cholinergic agonists and antagonists on the binding of the tritiated alpha-neurotoxin.

1974 • 148 citations

Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor

1991 • 148 citations

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

1991 • 148 citations

Neurotoxins and Their Pharmacological Implications

1988 • 147 citations

Identification of a New Component of the Agonist Binding Site of the Nicotinic α7 Homooligomeric Receptor

1995 • 147 citations

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist.

1992 • 145 citations

Three subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors are expressed in chick retina

1993 • 142 citations

Stimulation of mouse heart and liver microsomal lipid peroxidation by anthracycline anticancer drugs: characterization and effects of reactive oxygen scavengers.

1983 • 138 citations

Restoration of shock‐suppressed behavior by treatment with (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 137 citations

Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization

1982 • 135 citations

A role for the nicotinic α-bungarotoxin receptor in neurite outgrowth in PC12 cells

1993 • 133 citations

Activity-dependent regulation of gene expression in muscle and neuronal cells

1989 • 133 citations

Distinct agonist- and antagonist-binding sites on the glycine receptor

1992 • 132 citations

Calcium permeability of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells

1993 • 130 citations

A morphological study of the cholinergic receptor protein from Torpedo marmorata in its membrane environment and in its detergent-extracted purified form

1978 • 130 citations

The anticonvulsant MK-801 interacts with peripheral and central nicotinic acetylcholine receptor ion channels.

1990 • 130 citations

Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists.

1994 • 129 citations

Calcitonin gene-related peptide regulates phosphorylation of the nicotinic acetylcholine receptor in rat myotubes

1989 • 129 citations

Transsynaptic Control of Gene Expression

1993 • 124 citations

Coexpression of multiple acetylcholine receptor genes in neurons: quantification of transcripts during development.

1993 • 124 citations

A molecular view of neurotransmitter receptors and ionic channels.

1987 • 121 citations

Ultrastructure of isolated membranes ofTorpedo electric tissue

1973 • 120 citations

Identification of a local anesthetic binding site in nicotinic post-synaptic membranes isolated from Torpedo marmorata electric tissue.

1979 • 120 citations

Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.

1991 • 119 citations

Neuronal ATP receptors and their mechanism of action

1993 • 119 citations

Contraction‐associated translocation of protein kinase C in rat skeletal muscle

1987 • 117 citations

Pharmacological properties of the homomeric α7 receptor

1992 • 117 citations

Coexpression of multiple acetylcholine receptor genes in neurons: quantification of transcripts during development

1993 • 113 citations

Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ

1976 • 113 citations

Effects of nicotine on local cerebral glucose utilization in the rat

1988 • 111 citations

Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site.

1992 • 111 citations

Immunochemical similarities between subunits of acetylcholine receptors from Torpedo, Electrophorus, and mammalian muscle

1979 • 110 citations

Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorata

1983 • 108 citations

Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor.

1992 • 106 citations

Desensitization of membrane-bound Torpedo acetylcholine receptor by amine noncompetitive antagonists and aliphatic alcohols: studies of [3H]acetylcholine binding and sodium-22 ion fluxes

1984 • 106 citations

Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor.

1977 • 105 citations

The developmental increase in ACh current densities on rat sympathetic neurons correlates with changes in nicotinic ACh receptor alpha-subunit gene expression and occurs independent of innervation

1994 • 103 citations

Dynamic properties of isolated acetylcholine receptor proteins: release of calcium ions caused by acetylcholine binding.

1976 • 103 citations

Fast Kinetic Studies on the Allosteric Interactions between Acetylcholine Receptor and Local Anesthetic Binding Sites

1979 • 102 citations

Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand.

1991 • 101 citations

Fidia Research Foundation neuroscience award lectures

1987 • 99 citations

Fidia Research Foundation Neuroscience award lectures

1991 • 99 citations

Pharmacology and Biophysical Properties of α7 and α7 ‐ α8 α‐Bungarotoxin Receptor Subtypes Immunopurified from the Chick Optic Lobe

1994 • 97 citations

The transmembrane domains of the nicotinic acetylcholine receptor contain alpha-helical and beta structures.

1994 • 96 citations

NMR solution structure of an .alpha.-bungarotoxin/nicotinic receptor peptide complex

1993 • 94 citations

Acetylcholine receptor-inducing factor from chicken brain increases the level of mRNA encoding the receptor alpha subunit.

1988 • 93 citations

Barium permeability of neuronal nicotinic receptor alpha 7 expressed in Xenopus oocytes

1993 • 92 citations

Acetylcholine Receptor Synthesis in Retina and Transport to Optic Tectum in Goldfish

1986 • 91 citations

Calcium permeability of neuronal nicotinic acetylcholine receptor channels in PC12 cells

1991 • 90 citations

Protein kinase C couples membrane excitation to acetylcholine receptor gene inactivation in chick skeletal muscle

1992 • 88 citations

Use of affinity chromatography for acetylcholine receptor purification

1972 • 87 citations

Distance between the Agonist and Noncompetitive Inhibitor Sites on the Nicotinic Acetylcholine Receptor

1989 • 85 citations

Stratification of the channel domain in neurotransmitter receptors

1993 • 80 citations

Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262.

1992 • 80 citations

Crosslinking of α‐bungarotoxin to the acetylcholine receptor from Torpedo marmorata by ultraviolet light irradiation

1982 • 79 citations

Effects of nicotine on distribution and release of 14C-norepinephrine and 14C-dopamine in rat brain striatum and hypothalamus slices

1974 • 78 citations

Regionally specific effects of acute and chronic nicotine on rates of catecholamine and 5-hydroxytryptamine synthesis in rat brain

1989 • 76 citations

Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. I. Transmembrane segment M2 of the nicotinic cholinergic receptor channel is a key pore-lining structure

1993 • 75 citations

Photoaffinity labeling of the acetylcholine binding sites on the nicotinic receptor by an aryldiazonium derivative

1988 • 74 citations

Steroids inhibit nicotinic acetylcholine receptors

1991 • 72 citations

Block of endplate channels by permeant cations in frog skeletal muscle.

1981 • 72 citations

Involvement of ion channels in the induction of proenkephalin A gene expression by nicotine and cAMP in bovine chromaffin cells.

1987 • 70 citations

Role of phosphorylation in desensitization of acetylcholine receptors expressed in Xenopus oocytes

1994 • 69 citations

Transverse distance between the membrane and the agonist binding sites on the Torpedo acetylcholine receptor: a fluorescence study

1994 • 68 citations

α4‐β2 and other nicotinic acetylcholine receptor subtypes as targets of psychoactive and addictive drugs

1992 • 67 citations

Functional properties and developmental regulation of nicotinic acetylcholine receptors on embryonic chicken sympathetic neurons

1989 • 66 citations

Differential expression of the neuronal acetylcholine receptor α2 subunit gene during chick brain development

1990 • 64 citations

Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region.

1992 • 63 citations

Design, synthesis and functional characterization of a pentameric channel protein that mimics the presumed pore structure of the nicotinic cholinergic receptor

1993 • 63 citations

Substance P modulates single-channel properties of neuronal nicotinic acetylcholine receptors

1990 • 62 citations

Ligand-gated ion channels

1990 • 59 citations

? subunits determine the time course of desensitization in rat ?3 neuronal nicotinic acetylcholine receptors

1991 • 59 citations

Acetylcholine may regulate its own nicotinic receptor-channel through the C-kinase system

1987 • 57 citations

Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes: role of the ? subunit in agonist sensitivity and desensitization

1991 • 56 citations

Stratified organization of the nicotinic acetylcholine receptor channel

1992 • 54 citations

Regions of β4·β2 subunit chimeras that contribute to the agonist selectivity of neuronal nicotinic receptors

1992 • 54 citations

Affinity labelling of neuronal acetylcholine receptors localizes acetylcholine‐binding sites to their β‐subunits

1987 • 53 citations

Mapping of ligand binding sites of neuronal nicotinic acetylcholine receptors using chimeric alpha subunits.

1993 • 52 citations

Peptide modulation of ACh receptor desensitization controls neurotransmitter release from chicken sympathetic neurons

1993 • 44 citations

Nicotinic potentiation of glutamatergic synapses in the prefrontal cortex: New insight into the analysis of the role of nicotinic receptors in cognitive functions

1994 • 44 citations

Pharmacology of nicotinic receptor‐mediated inhibition in rat dorsolateral septal neurones.

1991 • 43 citations

Problems and paradigms: Dystrophin as a mechanochemical transducer in skeletal muscle

1993 • 43 citations

The neurotoxin histrionicotoxin interacts with the putative ion channel of the nicotinic acetylcholine receptors in the central nervous system

1987 • 39 citations

Phosphorylation of myogenin in chick myotubes: regulation by electrical activity and by protein kinase C. Implications for acetylcholine receptor gene expression

1994 • 39 citations

Mechanisms involved in the transcriptional activation of proenkephalin gene expression in bovine chromaffin cells.

1990 • 39 citations

Glucocorticoids inhibit acetylcholine-induced current in chromaffin cells

1989 • 38 citations

Calcium entry through acetylcholine-channels can activate potassium conductance in bullfrog sympathetic neurons

1984 • 35 citations

Location of terbium binding sites on acetylcholine receptor-enriched membranes

1986 • 30 citations

Ciba Foundation Symposium 152 ‐ The Biology of Nicotine Dependence

2007 • 26 citations

Biophysical properties and regulation of GABAA receptor channels

1991 • 26 citations

On the Interaction between Cobra -Neurotoxin and the Acetylcholine Receptor

1976 • 24 citations

A negative charge in the M2 transmembrane segment of the neuronal α7 acetylcholine receptor increases permeability to divalent cations

1993 • 21 citations

Roots: Allosteric proteins: From regulatory enzymes to receptors

1993 • 21 citations

Autoregulation of phosphorylation of the nicotinic acetylcholine receptor

1994 • 21 citations

UN MODELE MOLECULAIRE DE REGULATION D'EFFICACITE AU NIVEAU POSTSYNAPTIQUE D'UNE SYNAPSE CHIMIQUE

1982 • 20 citations

International Symposium on Nicotine: The Effects of Nicotine on Biological Systems II

1994 • 18 citations

Nicotine-induced gene expression of proenkephalin in bovine chromaffin cells

1994 • 17 citations

Molecular Biology of Neuroreceptors and Ion Channels

1989 • 17 citations

Molecular biology of neuroreceptors and ion channels

1990 • 15 citations

Promise of nicotinic‐based therapeutic treatments

1994 • 9 citations

Mechanisms of Nicotine Stimulated Cell Proliferation in Normal and Neoplastic Neuroendocrine Lung Cells

1995 • 8 citations

Dynamic properties of isolated acetylcholine receptor proteins: Release of calcium ions caused by acetylcholine binding

1977 • 6 citations