Mechanisms of cooperativity and allosteric regulation in proteins

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Genetic regulatory mechanisms in the synthesis of proteins

1961 • 6,378 citations

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of Allostery

1970 • 2,874 citations

Allosteric proteins and cellular control systems

1963 • 2,187 citations

Hydrogen exchange and structural dynamics of proteins and nucleic acids

1983 • 1,329 citations

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

Enzyme-Catalyzed Phosphoryl Transfer Reactions

1980 • 1,120 citations

The Enzymology of Control by Feedback Inhibition

1962 • 1,003 citations

Crystal structure of trp represser/operator complex at atomic resolution

1988 • 899 citations

Haemoglobin: The structural changes related to ligand binding and its allosteric mechanism

1979 • 862 citations

Quenching of protein fluorescence by oxygen. Detection of structural fluctuations in proteins on the nanosecond time scale

1973 • 774 citations

X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human Deoxyhaemoglobin

1972 • 731 citations

Structure of the junction between communicating cells

1980 • 697 citations

‘Zinc fingers’: a novel protein motif for nucleic acid recognition

1987 • 676 citations

Regulation of Oxygen Affinity of Hemoglobin: Influence of Structure of the Globin on the Heme Iron

1979 • 662 citations

Structure of human oxyhaemoglobin at 2·1resolution

1983 • 618 citations

Synthetic Amphiphilic Peptide Models for Protein Ion Channels

1988 • 593 citations

Spin-state/stereochemical relationships in iron porphyrins: implications for the hemoproteins

1981 • 588 citations

Assembly and Stability of the Tobacco Mosaic Virus Particle

1964 • 549 citations

X-ray structure and refinement of carbon-monoxy (Fe II)-myoglobin at 1.5 Å resolution

1986 • 511 citations

Crystallographic refinement and atomic models of two different forms of citrate synthase at 2·7 and 1·7 Å resolution

1982 • 495 citations

Neutron diffraction reveals oxygen–histidine hydrogen bond in oxymyoglobin

1981 • 449 citations

CONTROL OF PYRIMIDINE BIOSYNTHESIS IN ESCHERICHIA COLI BY A FEED-BACK MECHANISM

1956 • 444 citations

Visualization of protein-nucleic acid interactions in a virus

1989 • 430 citations

Kinetics of the allosteric interactions of phosphofructokinase from Escherichia coli

1968 • 416 citations

Stereochemistry of cooperative mechanisms in hemoglobin

1987 • 414 citations

Protein disk of tobacco mosaic virus at 2.8 Å resolution showing the interactions within and between subunits

1978 • 406 citations

The influence of polyvalency on the binding properties of antibodies

1972 • 396 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Structure of myohemerythrin in the azidomet state at resolution

1987 • 377 citations

Two configurations of a channel-forming membrane protein

1984 • 368 citations

The three-dimensional structure of trp repressor

1985 • 342 citations

The molecular basis of blood diseases

1988 • 341 citations

3.2 Å structure of the copper-containing, oxygen-carrying protein Panulirus interruptus haemocyanin

1984 • 332 citations

Allosteric Interactions in Aspartate Transcarbamylase. II. Evidence for Different Conformational States of the Protein in the Presence and Absence of Specific Ligands

1968 • 316 citations

Novel subunit—subunit interactions in the structure of glutamine synthetase

1986 • 310 citations

Glucose-induced conformational change in yeast hexokinase.

1978 • 305 citations

Kinked DNA in crystalline complex with EcoRI endonuclease

1984 • 303 citations

Structural changes in glycogen phosphorylase induced by phosphorylation

1988 • 302 citations

An X-ray study of azide methaemoglobin

1966 • 294 citations

Discrimination between Oxygen and Carbon Monoxide and Inhibition of Autooxidation by Myoglobin

1989 • 292 citations

Hemoglobin as a receptor of drugs and peptides: x-ray studies of the stereochemistry of binding

1986 • 290 citations

The role of the distal histidine in myoglobin and haemoglobin

1988 • 288 citations

The allosteric transition of glycogen phosphorylase

1989 • 288 citations

New Structural Model of E. coli Aspartate Transcarbamylase and the Amino-acid Sequence of the Regulatory Polypeptide Chain

1968 • 276 citations

Structure and function of haemoglobin

1976 • 271 citations

Crystal structure of the complex of phosphofructokinase from Escherichia coli with its reaction products

1988 • 270 citations

Assembly and characterization of an accurate model for the diiron center in hemerythrin

1984 • 249 citations

Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes

1988 • 247 citations

The Structure of Arthropod Hemocyanins

1985 • 245 citations

The Feedback Control Mechanism of Biosynthetic L-Threonine Deaminase by L-Isoleucine

1961 • 243 citations

The crystal structure of trp aporepressor at 1.8 Å shows how binding tryptophan enhances DNA affinity

1987 • 240 citations

Haemocyanins

1982 • 232 citations

Crystal lattice packing is important in determining the bend of a DNA dodecamer containing an adenine tract.

1989 • 231 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

Gel retardation at low pH resolves trp repressor-DNA complexes for quantitative study.

1988 • 227 citations

Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli

1982 • 227 citations

Allosteric interactions in aspartate transcarbamylase. I. Binding of specific ligands to the native enzyme and its isolated subunits

1968 • 219 citations

2.5 Å structure of aspartate carbamoyltransferase complexed with the bisubstrate analog N-(phosphonacetyl)-l-aspartate

1987 • 210 citations

Allosteric Effects in Haemoglobin

1982 • 205 citations

Crystallographic Determination of Symmetry of Aspartate Transcarbamylase

1968 • 198 citations

The Structures and Related Functions of Phosphorylase a

1980 • 197 citations

DNA Binding by Proteins

1988 • 195 citations

Reaction of myoglobin with phenylhydrazine: a molecular doorstop

1984 • 190 citations

Allosteric Linkage

1967 • 187 citations

Identification of residues contributing to the Bohr effect of human haemoglobin

1980 • 185 citations

Complex of N-phosphonacetyl-l-aspartate with aspartate carbamoyltransferase

1988 • 175 citations

Hemoglobin tertiary structural change on ligand binding its role in the co-operative mechanism

1983 • 173 citations

The Relation between the Oxygen Equilibrium and Aggregation of Subunits in Lamprey Hemoglobin

1963 • 173 citations

Structure and control of phosphofructokinase from Bacillus stearothermophilus

1979 • 172 citations

Hemocyanin—a current perspective

1983 • 171 citations

Structural studies of the hemocyanin active site. 1. Extended x-ray absorption fine structure (EXAFS) analysis

1980 • 169 citations

Arrangement of the acetylcholine receptor subunits in the resting and desensitized states, determined by cryoelectron microscopy of crystallized Torpedo postsynaptic membranes.

1988 • 167 citations

The theory of inter-allelic complementation

1964 • 166 citations

Reversible protonation of the oxo bridge in a hemerythrin model compound. Synthesis, structure, and properties of (.mu.-hydroxo)bis(.mu.-acetato)bis[hydrotris(1-pyrazolyl)borato]diiron(III) [(HB(pz)3)Fe(OH)(O2CCH3)2Fe(HB(pz)3)2]+

1984 • 163 citations

Structure of maltoheptaose by difference Fourier methods and a model for glycogen

1982 • 161 citations

Structure of the expanded state of tomato bushy stunt virus

1982 • 158 citations

Escherichia coli Aspartate Transcarbamylase: the Relation Between Structure and Function

1988 • 157 citations

Purification and characterization of trp aporepressor.

1983 • 150 citations

Isoleucine and Valine Metabolism in Escherichia coli

1958 • 143 citations

Allosteric Interactions in Aspartate Transcarbamylase. III. Interpretation of Experimental Data in Terms of the Model of Monod, Wyman, and Changeux

1968 • 143 citations

Allosteric regulation of aspartate transcarbamoylase. Analysis of the structural and functional behavior in terms of a two-state model

1977 • 139 citations

Flexibility of the DNA‐binding domains of trp repressor

1988 • 133 citations

Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b.

1987 • 133 citations

Allosteric regulation of aspartate transcarbamoylase. Changes in the sedimentation coefficient promoted by the bisubstrate analog N-(phosphonacetyl)-L-aspartate

1977 • 131 citations

M2 delta, a candidate for the structure lining the ionic channel of the nicotinic cholinergic receptor.

1988 • 130 citations

Mutational studies with the trp repressor of Escherichia coli support the helix-turn-helix model of repressor recognition of operator DNA.

1985 • 128 citations

Direct Measurement of the pK Values of an Alkaline Bohr Group in Human Hemoglobin

1973 • 127 citations

Active site structures of deoxyhemerythrin and oxyhemerythrin.

1985 • 126 citations

Structure of myoglobin-ethyl isocyanide histidine as a swinging door for ligand entry

1989 • 126 citations

Detection and Isolation of the Repressor Protein for the Tryptophan Operon of Escherichia coli

1972 • 122 citations

Penetration of dioxygen into proteins studied by quenching of phosphorescence and fluorescence

1983 • 120 citations

Biomimetic ion transport: a functional model of a unimolecular ion channel

1989 • 118 citations

Interactions between the quaternary structure of the globin and the spin state of the heme in ferric mixed spin derivatives of hemoglobin

1978 • 117 citations

Regulation of in vitro Transcription of the Tryptophan Operon by Purified RNA Polymerase in the Presence of Partially Purified Repressor and Tryptophan

1973 • 116 citations

The Affinity of Antibody: Range, Variability, and the Role of Multivalence

1978 • 116 citations

Refined atomic model of glutamine synthetase at 3.5 Å resolution

1989 • 115 citations

Can a simple model account for the allosteric transition of aspartate transcarbamoylase?

1988 • 111 citations

[11] Phosphofructokinases from Escherichia coli

1982 • 109 citations

Influence of quaternary structure of the globin on thermal spin equilibria in different methemoglobin derivatives

1978 • 109 citations

Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorata

1983 • 108 citations

Kinetics of hemoglobin and transition state theory.

1978 • 106 citations

The “chundle” approach to molecular channels synthesis of a macrocycle-based molecular bundle

1988 • 105 citations

Comparison Between the Amino-Acid Sequences of Sperm Whale Myoglobin and of Human Hæmoglobin

1961 • 103 citations

Shared active sites in oligomeric enzymes: model studies with defective mutants of aspartate transcarbamoylase produced by site-directed mutagenesis.

1987 • 101 citations

The nicotinic acetylcholine receptor: Molecular architecture of a ligand-regulated ion channel

1987 • 101 citations

Spectroscopic studies of the binuclear ferrous active site of deoxyhemerythrin: coordination number and probable bridging ligands for the native and ligand-bound forms

1987 • 99 citations

Quaternary structure changes in aspartate transcarbamylase studied by X-ray solution scattering

1985 • 98 citations

Structure of unligated aspartate carbamoyltransferase of Escherichia coli at 2.6-A resolution.

1984 • 98 citations

Effects of protons on the oxygenation-linked subunit assembly in human hemoglobin

1984 • 97 citations

Reactivity of ferric Aplysia and sperm whale myoglobins towards imidazole

1982 • 96 citations

Resonance Raman study of the .mu.-oxo-bridged binuclear iron center in oxyhemerythrin

1984 • 93 citations

A deoxymyoglobin model with a sterically unhindered axial imidazole

1988 • 90 citations

Subunit composition, X-ray diffraction, amino acid analysis and oxygen binding behaviour of Panulirus interruptus hemocyanin

1975 • 89 citations

Production and Crystallization of Aspartate Transcarbamylase

1960 • 89 citations

Structure of the liganded T state of haemoglobin identifies the origin of cooperative oxygen binding

1988 • 88 citations

DNA specificity determinants of Escherichia coli tryptophan repressor binding.

1987 • 87 citations

Assignment of resonances in the 1H nuclear magnetic resonance spectrum of the carbon monoxide complex of sperm whale myoglobin by phase-sensitive two-dimensional techniques

1987 • 84 citations

Pseudo 2-fold symmetry in the copper-binding domain of arthropodan haemocyanins

1989 • 83 citations

A possible model for the concerted allosteric transition in Escherichia coli aspartate transcarbamylase as deduced from site-directed mutagenesis studies

1988 • 81 citations

Molecular mechanism of acetylcholine receptor-controlled ion translocation across cell membranes

1980 • 80 citations

The structural basis for the interaction between L-tryptophan and the Escherichia coli trp aporepressor.

1987 • 80 citations

Carbon monoxide binding by hemocyanins of Limulus polyphemus, Busycon carica, and Callinectes sapidus

1974 • 80 citations

AMINO ACID BIOSYNTHESIS IN ESCHERICHIA COLI: ISOTOPIC COMPETITION WITH C14-GLUCOSE

1954 • 80 citations

Mutations in the active site of Escherichia coli phosphofructokinase

1987 • 80 citations

Nucleic Acids and Molecular Biology

1987 • 79 citations

Nesting: hierarchies of allosteric interactions.

1987 • 75 citations

Three-dimensional structure of carbamoyl phosphate and succinate bound to aspartate carbamoyltransferase.

1988 • 74 citations

Structure of Lamprey Haemoglobin

1971 • 74 citations

trp repressor arms contribute binding energy without occupying unique locations on DNA

1989 • 71 citations

Helix movements in proteins

1985 • 69 citations

Tobacco Mosaic Virus Protein Aggregation and the Virus Assembly

1977 • 67 citations

Interactions of phosphate ligands with Escherichia coli aspartate carbamoyltransferase in the crystalline state

1982 • 66 citations

Relationship between domain closure and binding, catalysis, and regulation in Escherichia coli aspartate transcarbamylase

1988 • 66 citations

Substrate-cofactor interactions for glycogen phosphorylase b: a binding study in the crystal with heptenitol and heptulose 2-phosphate

1984 • 66 citations

The Role of Pyridoxal Phosphate in the Catalysis of Glycogen Phosphorylases

1980 • 65 citations

Allosteric modulation of Callinectes sapidus hemocyanin by binding of L-lactate

1984 • 64 citations

Analysis of proton release in oxygen binding by hemoglobin: implications for the cooperative mechanism

1988 • 63 citations

Glycogen phosphorylase structures and function

1982 • 62 citations

Allosteric regulation of aspartate transcarbamoylase. Effect of active site ligands on the reactivity of sulfhydryl groups of the regulatory subunits

1977 • 60 citations

Structural characterization of a sterically encumbered iron(II) porphyrin carbonyl complex

1989 • 59 citations

Homotropic effects in aspartate transcarbamoylase

1985 • 59 citations

Domain Separation in the Activation of Glycogen Phosphorylasea

1989 • 55 citations

The structure of trp pseudorepressor at 1.65Å shows why indole propionate acts as a trp 'inducer'

1988 • 54 citations

Linkage graphs: a study in the thermodynamics of macromolecules

1984 • 53 citations

The active site of hemerythrin as determined by x-ray absorption fine structure

1988 • 52 citations

Intracellular Trp repressor levels in Escherichia coli

1986 • 51 citations

Glutamine synthetase forms three- and seven-stranded helical cables.

1975 • 51 citations

Divalent ion-dependent reversible swelling of tomato bushy stunt virus and organization of the expanded virion

1982 • 51 citations

Some Evolutionary Relationships of the Primary Biological Catalysts Glutamine Synthetase and RuBisCO

1987 • 51 citations

Synthesis of Tryptophan Operon RNA in a Cell-free System

1973 • 50 citations

Concerted allosteric transition in hybrids of aspartate transcarbamoylase containing different arrangements of active and inactive sites

1976 • 49 citations

Oxygen Equilibrium of Brachiopod Lingula Hemerythrin

1960 • 48 citations

Conversion of allosteric inhibition to activation in phosphofructokinase by protein engineering

1987 • 48 citations

Cooperative binding of the bisubstrate analog N-(phosphonacetyl)-L-aspartate to aspartate transcarbamoylase and the heterotropic effects of ATP and CTP

1989 • 45 citations

Influence of DPG on the bohr effect of human hemoglobin

1974 • 44 citations

Octopus dofleini hemocyanin: structure of the seven-domain polypeptide chain

1987 • 43 citations

LR16, a compound with potent effects on the oxygen affinity of hemoglobin, on blood cholesterol, and on low density lipoprotein.

1988 • 40 citations

Allosteric effects: structural and thermodynamic origins of binding in cooperativity in a subunit model

1983 • 39 citations

Crystallographic structure of allosterically inhibited phosphofructokinase at 7 Å resolution

1986 • 38 citations

Changes in stability and allosteric properties of aspartate transcarbamoylase resulting from amino acid substitutions in the zinc-binding domain of the regulatory chains.

1989 • 37 citations

Function of arginine-234 and aspartic acid-271 in domain closure, cooperativity, and catalysis in Escherichia coli aspartate transcarbamylase

1988 • 36 citations

The Self-Association and Oxygen Equilibrium of Hemoglobin from the Lamprey, Entosphenus japonicus

1973 • 35 citations

Oxygen equilibria of Octopus dofleini hemocyanin

1985 • 34 citations

Cooperative Interactions in Aspartate Transcarbamoylase. 1. Hybrids Composed of Native and Chemically Inactivated Catalytic Polypeptide Chains

1974 • 34 citations

Antibody Affinity

1974 • 34 citations

Site-directed mutagenesis in the effector site of Escherichia coli phosphofructokinase

1987 • 33 citations

The intermediate compounds between human hemoglobin and carbon monoxide at equilibrium and during approach to equilibrium.

1986 • 32 citations

NMR assignments for the amino-terminal residues of trp repressor and their role in DNA binding

1989 • 32 citations

Allosteric energy at the hemoglobin beta chain C terminus studied by hydrogen exchange

1988 • 30 citations

Analysis of the ligand-promoted global conformational change in aspartate transcarbamoylase

1989 • 28 citations

Multiple linkage in Panulirus interruptus hemocyanin

1979 • 28 citations

Isolation and properties of a species produced by the partial dissociation of aspartate transcarbamylase from Escherichia coli.

1975 • 27 citations

Quantitative evaluation for the role of beta 146 His and beta 143 His residues in the Bohr effect of human hemoglobin in the presence of 0.1 M chloride ion.

1984 • 25 citations

Kinetic control of co-operativity in the oxygen binding of Panulirus interruptus hemocyanin

1977 • 24 citations

Allosterische Effekte: Bindungskooperativität in einer Modellverbindung mit Untereinheiten

1981 • 22 citations

An x-ray absorption study of the binuclear iron center in deoxyhemerythrin

1983 • 22 citations

The stereochemical course of phosphoryl transfer catalysed by Bacillus stearothermophilus and rabbit skeletal-muscle phosphofructokinase with a chiral [16O,17O,18O]phosphate ester

1981 • 21 citations

Structure and activity of the tyrosy1-tRNA synthetase: the hydrogen bond in catalysis and specificity

1986 • 20 citations

Quaternary structure has little influence on spin states in mixed-spin human methemoglobins

1985 • 20 citations

New crystal forms of glutamine synthetase and implications for the molecular structure

1978 • 19 citations

Cooperativity in oxygen binding to Lingula reevii hemerythrin: spectroscopic comparison to the sipunculid hemerythrin coupled binuclear iron active site

1983 • 16 citations

Identical linkage and cooperativity of oxygen and carbon monoxide binding to Octopus dofleini hemocyanin

1989 • 16 citations

Control by phosphorylation

1988 • 15 citations

Boundary spreading in sedimentation velocity experiments on partially liganded aspartate transcarbamoylase

1989 • 13 citations

A comparative study of the activation of the cholinergic receptor by various agonists

1983 • 12 citations

New twists on an old story: hemoglobin

1988 • 11 citations

Ligand binding and stereochemical effects in hemocyanins

1982 • 10 citations