Neuropeptides in perspective: The last ten years

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Handbook of Chemical Neuroanatomy

1986 • 4,276 citations

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats

1981 • 3,128 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

1983 • 2,298 citations

Calcitonin gene-related peptide is a potent vasodilator

1985 • 2,050 citations

A new natriuretic peptide in porcine brain

1988 • 1,811 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

General Cytochemical Methods

1961 • 1,630 citations

Polypeptide with Broad Biological Activity: Isolation from Small Intestine

1970 • 1,577 citations

Fluorescent Antibody Methods

1969 • 1,549 citations

Peptidergic neurones

1980 • 1,523 citations

The Axon Reaction: A Review of the Principal Features of Perikaryal Responses to Axon Injury

1971 • 1,112 citations

Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species

1984 • 1,024 citations

Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes

1988 • 929 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

The changing scene of neurotrophic factors

1991 • 827 citations

A new method for receptor autoradiography: [3H]Opioid receptors in rat brain

1979 • 797 citations

Amino-acid Sequence of Substance P

1971 • 769 citations

cDNA eloping of bovine substance-K receptor through oocyte expression system

1987 • 748 citations

A subpopulation of mesencephalic dopamine neurons projecting to limbic areas contains a cholecystokinin-like peptide: Evidence from immunohistochemistry combined with retrograde tracing

1980 • 717 citations

Stimulation of connective tissue cell growth by substance P and substance K

1985 • 681 citations

Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27

1983 • 664 citations

Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma

1975 • 610 citations

The retrograde axonal transport of nerve growth factor

1974 • 598 citations

Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord.

1988 • 580 citations

Hypothalamic Regulatory Hormones

1973 • 574 citations

Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat

1984 • 573 citations

Coexistence of peptides and classical neurotransmitters

1983 • 559 citations

Structure and functional expression of the cloned rat neurotensin receptor

1990 • 529 citations

Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.

1990 • 501 citations

Muscle but not cutaneous C‐afferent input produces prolonged increases in the excitability of the flexion reflex in the rat.

1984 • 500 citations

Brain Peptides as Neurotransmitters

1980 • 486 citations

Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis

1986 • 472 citations

Occurrence of somatostatin-like immunoreactivity in some peripheral sympathetic noradrenergic neurons

1977 • 466 citations

Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.

1980 • 463 citations

Molecular characterization of a functional cDNA for rat substance P receptor

1989 • 463 citations

Neuropeptide expression in rat dorsal root ganglion cells and spinal cord after peripheral nerve injury with special reference to galanin

1989 • 460 citations

Long Term Effect of Vasopressin on the Maintenance of a Conditioned Avoidance Response in Rats

1971 • 456 citations

Substance P: Depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons

1979 • 455 citations

Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral axotomy

1987 • 448 citations

Spinal Cord Reconstruction

1983 • 437 citations

Pharmacological evidence that adenosine triphosphate and noradrenaline are co‐transmitters in the guinea‐pig vas deferens.

1984 • 416 citations

Regional distribution of neurotensin and somatostatin in rat brain

1977 • 408 citations

Volume transmission in the brain. Novel mechanisms for neural transmission

1992 • 388 citations

Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats

1987 • 359 citations

The possible existence of multiple receptors for substance P

1982 • 357 citations

Molecular Characterization of a Functional cDNA Encoding the Rat Substance P Receptor

1990 • 355 citations

Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism.

1981 • 352 citations

Pathway-specific patterns of the co-existence of substance P, calcitonin gene-related peptide, cholecystokinin and dynorphin in neurons of the dorsal root ganglia of the guinea-pig

1987 • 352 citations

Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia.

1989 • 349 citations

Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo, and in vitro studies.

1987 • 347 citations

Neurotransmitter candidates of somatosensory primary afferent fibres

1983 • 331 citations

Coexistence of peptides with classical neurotransmitters

1987 • 327 citations

Calcitonin gene-related peptide is a potent inhibitor of substance P degradation

1985 • 326 citations

Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy Volunteers

1989 • 322 citations

Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin.

1986 • 322 citations

Galanin-like immunoreactivity in cholinergic neurons of the septum-basal forebrain complex projecting to the hippocampus of the rat

1985 • 321 citations

Vasoactive intestinal peptide regulates mitosis, differentiation and survival of cultured sympathetic neuroblasts

1990 • 317 citations

Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes

1986 • 312 citations

Benzodiazepine gastrin and brain cholecystokinin receptor ligands; L-365,260

1989 • 304 citations

Innervation of Periosteum and Bone by Sympathetic Vasoactive Intestinal Peptide-Containing Nerve Fibers

1986 • 293 citations

Substance P and calcitonin gene-related peptide synergistically modulate the gain of the nociceptive flexor withdrawal reflex in the rat

1986 • 292 citations

Cholecystokinin-Tetrapeptide Induces Panic Attacks in Patients with Panic Disorder

1990 • 289 citations

Neurotensin receptors are located on dopamine-containing neurones in rat midbrain

1981 • 285 citations

Chapter 15 Chemical coding of enteric neurons

1986 • 285 citations

Vasoactive intestinal peptide and electrical activity influence neuronal survival.

1986 • 283 citations

Galanin hyperinnervates surviving neurons of the human basal nucleus of meynert in dementias of alzheimer's and parkinson's disease: A hypothesis for the role of galanin in accentuating cholinergic dysfunction in dementia

1988 • 273 citations

The selective CCK-B receptor antagonist L-365,260 enhances morphine analgesia and prevents morphine tolerance in the rat

1990 • 270 citations

Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section

1985 • 268 citations

Evidence for differential localization of noradrenaline and neuropeptide Y in neuronal storage vesicles isolated from rat vas deferens

1985 • 261 citations

Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways.

1987 • 247 citations

Postponement of Satiety by Blockade of Brain Cholecystokinin (CCK-B) Receptors

1989 • 241 citations

Tachykinins and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice

1990 • 229 citations

Differential effect of alpha-latrotoxin on exocytosis from small synaptic vesicles and from large dense-core vesicles containing calcitonin gene-related peptide at the frog neuromuscular junction.

1988 • 221 citations

Chapter 12 Regulation of multiple peptides in CRF parvocellular neurosecretory neurons: implications for the stress response

1986 • 220 citations

Increased Brain Size and Cellular Content in Infant Rats Treated with an Opiate Antagonist

1983 • 218 citations

Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes

1990 • 213 citations

Calcitonin gene-related peptide elevates cyclic AMP levels in chick skeletal muscle: possible neurotrophic role for a coexisting neuronal messenger.

1987 • 207 citations

α-CGRP and β-CGRP mRNAs are differentially regulated in the rat spinal cord and dorsal root ganglion

1990 • 207 citations

Vasoactive intestinal polypeptide (VIP) increases in the spinal cord after peripheral axotomy of the sciatic nerve originate from primary afferent neurons

1986 • 199 citations

Nerve growth factor stimulates the development of substance P in sensory ganglia.

1980 • 198 citations

Exocytosis from Neuronal Large Dense-Cored Vesicles

1990 • 196 citations

Effects of neonatal sympathectomy and capsaicin treatment on bone remodeling in rats

1991 • 192 citations

Substance P and Spinal Neurones

1975 • 183 citations

VIP and noradrenaline act synergistically to increase cyclic AMP in cerebral cortex

1984 • 174 citations

Two novel related peptides, neuropeptide Y (NPY) and peptide YY (PYY) inhibit the contraction of the electrically stimulated mouse vas deferens

1982 • 172 citations

Localization of chemical messengers in magnocellular neurons of the hypothalamic supraoptic and paraventricular nuclei: An immunohistochemical study using experimental manipulations

1990 • 172 citations

Vasoactive intestinal polypeptide stimulates cell proliferation and adenylate cyclase activity of cultured human keratinocytes.

1989 • 170 citations

PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexes.

1990 • 169 citations

Distribution and Coexistence of Corticotropin-Releasing Factor-, Neurotensin-, Enkephalin-, Cholecystokinin-, Galanin- and Vasoactive Intestinal Polypeptide/Peptide Histidine Isoleucine-Like Peptides in the Parvocellular Part of the Paraventricular Nucleus

1989 • 166 citations

Substance P modulates glutamate-induced currents in acutely isolated rat spinal dorsal horn neurones

1990 • 165 citations

Frequency-dependent release of peptide cotransmitters from identified cholinergic motor neurons in Aplysia.

1989 • 162 citations

Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord

1990 • 159 citations

Dale's hypothesis revisited: different neuropeptides derived from a common prohormone are targeted to different processes.

1990 • 159 citations

M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord.

1991 • 158 citations

On the Role of Galanin, Substance P and Other Neuropeptides in Primary Sensory Neurons of the Rat: Studies on Spinal Reflex Excitability and Peripheral Axotomy

1990 • 149 citations

mRNA coding for oxytocin is present in axons of the hypothalamo-neurohypophysial tract.

1990 • 148 citations

Extracellular dopamine and neurotensin in rat prefrontal cortex in vivo: effects of median forebrain bundle stimulation frequency, stimulation pattern, and dopamine autoreceptors

1991 • 145 citations

Expression of dopaminergic phenotypes in the mouse olfactory bulb induced by the calcitonin gene-related peptide

1989 • 132 citations

Actions of calcitonin gene-related peptide on rat spinal dorsal horn neurons

1988 • 130 citations

Localization of neuropeptide receptor mRNA in rat brain: Initial observations using probes for neurotensin and substance P receptors

1990 • 129 citations

Galanin impairs acquisition but not retrieval of spatial memory in rats studied in the Morris swim maze

1988 • 129 citations

Cranial motor neurons contain either galanin‐ or calcitonin gene‐related peptidelike immunoreactivity

1989 • 128 citations

Immunohistochemical demonstration of glutaminase in catecholaminergic and serotoninergic neurons of rat brain

1990 • 124 citations

Galanin‐like immunoreactivity within the primate basal forebrain: Differential staining patterns between humans and monkeys

1990 • 119 citations

A galanin-like peptide coexists in putative cholinergic somata of the septum-basal forebrain complex and in acetylcholinesterase-containing fibers and varicosities within the hippocampus in the owl monkey (aotus trivirgatus)

1986 • 118 citations

Selective excitation of neurons in the mammalian spinal dorsal horn by aspartate and glutamate in vitro: correlation with location and excitatory input

1985 • 116 citations

Galanin and Glibenclamide Modulate the Anoxic Release of Glutamate in Rat CA3 Hippocampal Neurons

1990 • 115 citations

STIMULATORY EFFECTS OF SUBSTANCE P ON NEURITE EXTENSION AND CYCLIC AMP LEVELS IN CULTURED NEUROBLASTOMA CELLS

1978 • 115 citations

Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats.

1988 • 115 citations

Direct evidence for concomitant release of noradrenaline, adenosine 5′-triphosphate and neuropeptide Y from sympathetic nerve supplying the guinea-pig vas deferens

1988 • 114 citations

Human galanin: Primary structure and indentification of two molecular forms

1991 • 112 citations

Calcitonin gene-related peptide increases in rat facial motoneurons after peripheral nerve transection

1989 • 112 citations

Peptidergic neurons in the basal forebrain magnocellular complex of the rhesus monkey

1989 • 108 citations

Neurons with galanin innervate cholinergic cells in the human basal forebrain and galanin and acetylcholine coexist

1988 • 107 citations

Identification of the motoneuron-depolarizing peptide in bovine dorsal root as hypothalamic substance P

1974 • 107 citations

Peripheral nerve section induces increased levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity in axotomized motoneurons

1990 • 103 citations

Peptide expression is altered when afferent nerves reinnervate inappropriate tissue

1987 • 100 citations

Iontophoretic application of calcitonin gene-related peptide produces a slow and prolonged excitation of neurons in the cat lumbar dorsal horn

1988 • 98 citations

Functional role of brain CCK receptors

1991 • 98 citations

Calcitonin gene-related peptide prevents disuse-induced sprouting of rat motor nerve terminals

1988 • 97 citations

Substance P Counteracts Neurotoxin Damage on Norepinephrine Neurons in Rat Brain During Ontogeny

1982 • 97 citations

Distribution of cholecystokinin‐immunoreactive cell bodies in the male and female rat: II. Bed nucleus of the stria terminalis and amygdala

1988 • 97 citations

Effects of central nervous system lesions on the expression of galanin: a comparative in situ hybridization and immunohistochemical study.

1990 • 95 citations

Presence of endothelin-1 in porcine spinal cord: Isolation and sequence determination

1989 • 92 citations

Differential release of coexisting neurotransmitters: frequency dependence of the efflux of substance P, thyrotropin releasing hormone and [³H]serotonin from tissue slices of rat ventral spinal cord

1989 • 89 citations

Subcellular fractionation of cat submandibular gland: Comparative studies on the distribution of acetylcholine and vasoactive intestinal polypeptide (VIP)

1981 • 89 citations

Localization of calcitonin gene-related peptide and its receptors in a striated muscle

1989 • 88 citations

Effect of Calcitonin Gene-Related Peptide on the Cyclic AMP Level of Isolated Mouse Diaphragm

1986 • 88 citations

Glutamic Acid Decarboxylase- and γ-Aminobutyric Acid-Like Immunoreactivities in Corticotropin-Releasing Factor-Containing Parvocellular Neurons of the Hypothalamic Paraventricular Nucleus

1988 • 87 citations

Castration reversibly alters levels of cholecystokinin immunoreactivity within cells of three interconnected sexually dimorphic forebrain nuclei in the rat.

1987 • 85 citations

On a brain polypeptide functioning as a putative effector for the recognition sites of benzodiazepine and beta-carboline derivatives

1983 • 84 citations

Effect of naloxone and D-Met2-Pro5-enkephalinamide treatment on the DNA synthesis in the developing rat brain

1982 • 78 citations

Role of NK1 tachykinin receptors in thermonociception: Effect of (±)-CP 96,345, a non-peptide substance P antagonist, on the hot plate test in mice

1991 • 74 citations

Rat facial motoneurons express increased levels of calcitonin gene‐related peptide mRNA in response to axotomy

1990 • 73 citations

The neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) can activate a ligand-gated ion channel in Helix neurons

1990 • 72 citations

Calcitonin Gene‐related Peptide (CGRP)‐like Immunoreactivity and CGRP mRNA in Rat Spinal Cord Motoneurons after Different Types of Lesions

1991 • 69 citations

Retrograde axonal transport of neurotensin in the dopaminergic nigrostriatal pathway in the rat

1990 • 69 citations

The action of calcitonin gene-related peptide on astrocyte morphology and cyclic AMP accumulation in astrocyte cultures from neonatal rat brain

1991 • 65 citations

Chapter 1 Chemical transmission and Dale's principle

1986 • 60 citations

Co-localized GABA and somatostatin use different ionic mechanisms to hyperpolarize target neurons in the lamprey spinal cord

1991 • 60 citations

Chapter 11 Multiple chemical messengers in hypothalamic magnocellular neurons

1986 • 59 citations

Design and Synthesis of Effective Antagonists of Substance P.

1982 • 52 citations

Does cholecystokinin colocalize with dopamine in the human substantia nigra?

1989 • 48 citations

Substance P and NMDA receptors mediate a slow nociceptive ventral root potential in neonatal rat spinal cord

1991 • 45 citations

Immunoreactive Calcitonin Gene‐Related Peptide, Vasoactive Intestinal Polypeptide, and Somatostatin in Developing Chicken Spinal Cord Motoneurons

1989 • 45 citations

Glutamate-like immunoreactivity in medulla oblongata catecholamine/substance P neurons

1990 • 44 citations

Changes from enkephalin-like to gastrin/cholecystokinin-like immunoreactivity in snail neurons

1985 • 43 citations

Chick myotubes in culture express high-affinity receptors for calcitonin gene-related peptide

1989 • 40 citations

Intrathecal galanin antagonizes the facilitatory effect of substance P on the nociceptive flexor reflex in the rat

1989 • 38 citations

Characterization and developmental evolution of a high-affinity binding site for calcitonin gene-related peptide on chick skeletal muscle membrane

1991 • 38 citations

Calcitonin gene-related peptide staining intensity is reduced in rat lumbar motoneurons after spinal cord transection: a quantitative immunocytochemical study

1990 • 36 citations

Gastrointestinal Hormones

1988 • 36 citations

Calcitonin gene-related peptide modulates calcium mobilization in synaptosomes of rat spinal dorsal horn

1988 • 32 citations

Biochemical and physiological correlates of hypothalamic peptides. The new endocrinology of the neuron.

1978 • 32 citations

Exocytosis of secretory granules — a probable mechanism for the release of neuromodulators in invertebrate neuropiles

1984 • 31 citations

Coexistence of neuronal messengers : a new principle in chemical transmission : proceedings of the Marcus Wallenberg Symposium, held at the Grand Hotel, Saltsjöbaden, Stockholm, on 26-28 June 28, 1985

1986 • 27 citations

Fast and slow chemical signalling in the nervous system

1986 • 25 citations

Neuropeptide Y, Peptide HI, Galanin, Cholecystokinin-58, Neuropeptide K, and Peptide YY

1988 • 1 citations