Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Cell Death

2004 • 4,599 citations

Mitochondria, Oxidants, and Aging

2005 • 4,115 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Signaling to NF-κB

2004 • 3,768 citations

Nuclear factor-κB in cancer development and progression

2006 • 3,334 citations

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

Reactive oxygen species in cell signaling

2000 • 2,844 citations

Signalling pathways of the TNF superfamily: a double-edged sword

2003 • 2,602 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

Tumor necrosis factor signaling

2003 • 2,262 citations

Cellular response to oxidative stress: Signaling for suicide and survival*

2002 • 2,258 citations

Introduction to NF-κB: players, pathways, perspectives

2006 • 2,115 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

2005 • 1,727 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Balancing Acts

2004 • 1,663 citations

Four deaths and a funeral: from caspases to alternative mechanisms

2001 • 1,605 citations

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

1992 • 1,524 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

The IKK NF-κB system: a treasure trove for drug development

2004 • 1,340 citations

Death by design: apoptosis, necrosis and autophagy

2004 • 1,330 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis

2005 • 1,125 citations

Regulation of ferritin genes and protein

2002 • 1,103 citations

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

2005 • 1,102 citations

Reactive Oxygen Species as Intracellular Messengers During Cell Growth and Differentiation

2001 • 1,092 citations

Nuclear factor-?B: its role in health and disease

2004 • 908 citations

Oxidative stress and nuclear factor-κB activation

2000 • 865 citations

Redox Regulation of NF-kappa B Activation

1997 • 852 citations

More than one way to die: apoptosis, necrosis and reactive oxygen damage

1999 • 850 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Is NF-kappaB the sensor of oxidative stress?

1999 • 786 citations

To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis

2003 • 738 citations

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

2001 • 725 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

2006 • 685 citations

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

2000 • 674 citations

Is NF‐κB the sensor of oxidative stress?

1999 • 669 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways

2006 • 655 citations

Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

2006 • 652 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression

2006 • 648 citations

IκB kinase complexes: gateways to NF-κB activation and transcription

2006 • 628 citations

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

2004 • 625 citations

Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

1999 • 597 citations

Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain

2004 • 587 citations

ROS, stress‐activated kinases and stress signaling in cancer

2002 • 585 citations

Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1

1998 • 580 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

Regulation and measurement of oxidative stress in apoptosis

2002 • 567 citations

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

2003 • 557 citations

Inhibitors of NF-κB signaling: 785 and counting

2006 • 553 citations

Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

1998 • 553 citations

NF-κB as a therapeutic target in cancer

2002 • 550 citations

Redox Regulation of NF-κB Activation: Distinct Redox Regulation Between the Cytoplasm and the Nucleus

2005 • 548 citations

Roles for NF-κB in nerve cell survival, plasticity, and disease

2006 • 540 citations

Ferritin, iron homeostasis, and oxidative damage1,2 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.

2002 • 507 citations

NF- B inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

2003 • 494 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Compartmentalization of TNF Receptor 1 Signaling

2004 • 479 citations

Good cop, bad cop: the different faces of NF-κB

2006 • 473 citations

Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors

2002 • 426 citations

Nitrosation and oxidation in the regulation of gene expression

2000 • 422 citations

Regulatory Role for a Novel Human Thioredoxin Peroxidase in NF-κB Activation

1997 • 414 citations

From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance

2005 • 406 citations

Current insights into the regulation of programmed cell death by NF-κB

2006 • 399 citations

The IKK/NF-κB activation pathway—a target for prevention and treatment of cancer

2003 • 399 citations

NF-κB and IKK as therapeutic targets in cancer

2006 • 391 citations

Evidence that reactive oxygen species do not mediate NF- B activation

2003 • 385 citations

Caspase-independent cell death in T lymphocytes

2003 • 368 citations

Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase

2000 • 353 citations

Reactive oxygen species mediate crosstalk between NF-κB and JNK

2005 • 344 citations

Gadd45β mediates the NF-κB suppression of JNK signalling by targeting MKK7/JNKK2

2004 • 312 citations

Immune cells: free radicals and antioxidants in sepsis

2004 • 311 citations

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

1999 • 303 citations

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

2004 • 294 citations

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

2003 • 288 citations

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation

1999 • 285 citations

Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression.

1996 • 283 citations

Dithiocarbamates Induce Apoptosis in Thymocytes by Raising the Intracellular Level of Redox-active Copper

1995 • 280 citations

Stress-Responsive Protein Kinases in Redox-Regulated Apoptosis Signaling

2005 • 276 citations

Redox regulation of OxyR requires specific disulfide bond formation involving a rapid kinetic reaction path

2004 • 261 citations

Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment

2001 • 260 citations

JunD Mediates Survival Signaling by the JNK Signal Transduction Pathway

2003 • 253 citations

Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress

2000 • 251 citations

Oxidative stress interference with the nuclear factor- κB activation pathways

2000 • 243 citations

Cross-talk between nuclear receptors and nuclear factor κB

2006 • 243 citations

Endothelial Apoptosis Induced by Oxidative Stress Through Activation of NF-κB

2001 • 236 citations

Reactive oxygen intermediates in TNF signaling

2002 • 228 citations

The NF-κB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease

2006 • 225 citations

Reactive Oxygen Intermediate-Dependent NF-κB Activation by Interleukin-1β Requires 5-Lipoxygenase or NADPH Oxidase Activity

1999 • 224 citations

Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB

1995 • 224 citations

Spatial Redox Regulation of a Critical Cysteine Residue of NF-κB in Vivo

2002 • 218 citations

TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105

1999 • 214 citations

Caspase inhibition causes hyperacute tumor necrosis factor–induced shock via oxidative stress and phospholipase A2

2003 • 212 citations

Redox regulation of ubiquitin‐conjugating enzymes: mechanistic insights using the thiol‐specific oxidant diamide

1998 • 209 citations

The 90-kDa Ribosomal S6 Kinase (pp90rsk) Phosphorylates the N-terminal Regulatory Domain of IκBα and Stimulates Its Degradation in Vitro

1997 • 207 citations

Effects of oxidants and antioxidants on nuclear factor ϰB activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals

1995 • 206 citations

Regulation of gene expression by oxygen: NF-κB and HIF-1, two extremes

2002 • 200 citations

Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304

1997 • 190 citations

Cytokine-induced Activation of Nuclear Factor-κB Is Inhibited by Hydrogen Peroxide through Oxidative Inactivation of IκB Kinase

2001 • 189 citations

Multistep Carcinogenesis: A Chain Reaction of Aneuploidizations

2003 • 185 citations

Reactive Oxygen Species (ROS), Troublemakers between Nuclear Factor-κB (NF-κB) and c-Jun NH2-terminal Kinase (JNK)

2004 • 171 citations

Activation of AP‐1 and Nuclear Factor‐κB Transcription Factors Is Involved in Hydrogen Peroxide‐Induced Apoptotic Cell Death of Olligodendrocytes

1999 • 171 citations

Induction of Oxidative Stress by Okadaic Acid Is Required for Activation of Transcription Factor NF-κB

1995 • 170 citations

Disruption of HSP90 Function Reverts Tumor Necrosis Factor-induced Necrosis to Apoptosis

2003 • 162 citations

Structural basis for redox regulation of Yap1 transcription factor localization

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Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-α-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain

1995 • 160 citations

Cell type-specific role for reactive oxygen species in nuclear factor-kappaB activation by Interleukin-1

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ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.

1994 • 150 citations

Reactive Oxygen Species Activate p90 Ribosomal S6 Kinase via Fyn and Ras

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Reactive Oxygen Species–Mediated Mitochondria-to-Nucleus Signaling: A Key to Aging and Radical-Caused Diseases

2006 • 138 citations

2-mercaptoethanol restores the ability of nuclear factor κB (NF κB) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NFκB by PDTC

1996 • 136 citations

Tyrosine phosphorylation‐dependent activation of NF‐κB

2001 • 131 citations

NF-κB RelA opposes epidermal proliferation driven by TNFR1 and JNK

2004 • 126 citations

Intrastriatal Dopamine Injection Induces Apoptosis Through Oxidation-Involved Activation of Transcription Factors AP-1 and NF-κB in Rats

1999 • 123 citations

Hydrogen Peroxide Activates NFκB and the Interleukin-6 Promoter Through NFκB-Inducing Kinase

2001 • 121 citations

Redox events in interleukin-1 signaling

2004 • 120 citations

Beginnings of a signal-transduction pathway for bioenergetic control of cell survival

2004 • 114 citations

NF-κB and the regulation of hematopoiesis

2006 • 109 citations

NF-κB-dependent MnSOD expression protects adenocarcinoma cells from TNF-α-induced apoptosis

2002 • 109 citations

Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants.

1994 • 105 citations

Deciphering the pathway from the TCR to NF-κB

2006 • 94 citations

Hydrogen Peroxide Has Opposing Effects on IKK Activity and I κ B α Breakdown in Airway Epithelial Cells

2001 • 92 citations

ZAP-70-dependent and -independent Activation of Erk in Jurkat T Cells

1998 • 89 citations

NF-kappaB-related genetic diseases.

2006 • 78 citations

Pervanadate-induced Nuclear Factor-κB Activation Requires Tyrosine Phosphorylation and Degradation of IκBα

2000 • 73 citations

Induction of β-Transducin Repeat-containing Protein by JNK Signaling and Its Role in the Activation of NF-κB

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Interleukin‐1β Induces Nuclear Factor κ B in Epithelial Cells Independently of the Production of Reactive Oxygen Intermediates

1996 • 69 citations

Cyanide-Induced Apoptosis Involves Oxidative-Stress-Activated NF-κB in Cortical Neurons

2000 • 62 citations

Antioxidants Differentially Regulate Activation of Nuclear Factor-κB, Activator Protein-1, c-Jun Amino-Terminal Kinases, and Apoptosis Induced by Tumor Necrosis Factor: Evidence that JNK and NF-κB Activation Are Not Linked to Apoptosis

1999 • 61 citations

Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-α–stimulated neutrophils

2002 • 59 citations

The role of Rel/NF-κB transcription factors in B lymphocyte survival

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Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species.

2002 • 54 citations

Distinct Roles of Basal Steady-State and Induced H-Ferritin in Tumor Necrosis Factor-Induced Death in L929 Cells

2005 • 51 citations

Deferoxamine reduces tissue injury and lethality in LPS-treated mice

2000 • 51 citations

Responses of vascular endothelial oxidant metabolism to lipopolysaccharide and tumor necrosis factor-α

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Transient Overexpression of Catalase Does Not Inhibit TNF- or PMA-Induced NF-κB Activation

1995 • 47 citations

JNK: a killer on a transcriptional leash

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NF-κB guides the survival and differentiation of developing lymphocytes

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Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS

2004 • 27 citations

Anti-Inflammatory Activities of Hypocretenolides from Leontodon hispidus

1999 • 22 citations

An endogenous redox molecule, thioredoxin, regulates transactivation of epidermal growth factor receptor and activation of NF‐κB by lysophosphatidic acid

2001 • 14 citations