Ferritin, iron homeostasis, and oxidative damage1,2 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.

The ferritins: molecular properties, iron storage function and cellular regulation

1996 • 2,572 citations

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

1996 • 1,311 citations

Ferritin: a cytoprotective antioxidant strategem of endothelium.

1992 • 1,100 citations

Tissue-Specific Regulation of Iron Metabolism and Heme Synthesis: Distinct Control Mechanisms in Erythroid Cells

1997 • 539 citations

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

2001 • 533 citations

Ferritin and the response to oxidative stress

2001 • 410 citations

Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin

1993 • 394 citations

A Human Mitochondrial Ferritin Encoded by an Intronless Gene

2001 • 386 citations

Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2 , by c-MYC

1999 • 319 citations

Maturation of cellular Fe-S proteins: an essential function of mitochondria

2000 • 308 citations

Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract

1995 • 294 citations

The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site.

2000 • 270 citations

Early Embryonic Lethality of H Ferritin Gene Deletion in Mice

2000 • 266 citations

Iron-Dependent Self-Assembly of Recombinant Yeast Frataxin: Implications for Friedreich Ataxia

2000 • 246 citations

Overexpression of Wild Type and Mutated Human Ferritin H-chain in HeLa Cells

2000 • 245 citations

Iron-independent induction of ferritin H chain by tumor necrosis factor.

1991 • 211 citations

H-Ferritin Subunit Overexpression in Erythroid Cells Reduces the Oxidative Stress Response and Induces Multidrug Resistance Properties

1999 • 206 citations

Role for NF-κB in the Regulation of Ferritin H by Tumor Necrosis Factor-α

1995 • 188 citations

Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: The role of ferritin

1999 • 177 citations

The Role of the L-Chain in Ferritin Iron Incorporation

1994 • 175 citations

Human Mitochondrial Ferritin Expressed in HeLa Cells Incorporates Iron and Affects Cellular Iron Metabolism

2002 • 158 citations

The Essential Role of Mitochondria in the Biogenesis of Cellular Iron-Sulfur Proteins

1999 • 158 citations

Evidence that a salt bridge in the light chain contributes to the physical stability difference between heavy and light human ferritins.

1992 • 137 citations

Identification of the EPR-Active Iron-Nitrosyl Complexes in Mammalian Ferritins

1994 • 117 citations

Iron homeostasis alteration in transgenic tobacco overexpressing ferritin

1999 • 117 citations

The Iron Oxidation and Hydrolysis Chemistry of Escherichia coli Bacterioferritin

2000 • 101 citations

Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution

1996 • 95 citations

Analysis of Ferritins in Lymphoblastoid Cell Lines and in the Lens of Subjects With Hereditary Hyperferritinemia-Cataract Syndrome

1998 • 93 citations

Transcriptional Regulation of the Ferritin Heavy-Chain Gene: the Activity of the CCAAT Binding Factor NF-Y Is Modulated in Heme-Treated Friend Leukemia Cells and during Monocyte-to-Macrophage Differentiation

1997 • 93 citations

Iron detoxifying activity of ferritin

1990 • 88 citations

Frataxin expression rescues mitochondrial dysfunctions in FRDA cells

2001 • 82 citations

Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones

1996 • 68 citations

Relationship between TNF‐α and iron metabolism in differentiating human monocytic THP‐1 cells

2000 • 64 citations

Is Hydrogen Peroxide Produced during Iron(II) Oxidation in Mammalian Apoferritins?

2001 • 64 citations

Hemin-Enhanced Resistance of Human Leukemia Cells to Oxidative Killing: Antisense Determination of Ferritin Involvement

1998 • 60 citations

The lens in hereditary hyperferritinaemia cataract syndrome contains crystalline deposits of L-ferritin

2000 • 59 citations

FER-1, an Enhancer of the Ferritin H Gene and a Target of E1A-Mediated Transcriptional Repression

1995 • 56 citations

Translational enhancement of H-ferritin mRNA by interleukin-1β acts through 5′ leader sequences distinct from the iron responsive element

1994 • 52 citations

Elevated Ferritin Production, Iron Containment, and Oxidant Resistance in Hemin-Treated Leukemia Cells

1997 • 47 citations

Plant ferritin accumulates in response to photoinhibition but its ectopic overexpression does not protect against photoinhibition

2001 • 47 citations

Transient overexpression of human H- and L-ferritin chains in COS cells

1998 • 47 citations

Iron storage and ferritin in plants.

1998 • 46 citations

Post-transcriptional Regulation of H-ferritin mRNA

1999 • 17 citations