Repair of alkylated DNA: Recent advances

SCOP: A structural classification of proteins database for the investigation of sequences and structures

1995 • 6,372 citations

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

Histone demethylation by a family of JmjC domain-containing proteins

2005 • 2,006 citations

The Role of DNA Methylation in Mammalian Epigenetics

2001 • 1,956 citations

Knowledge-Based Intelligent Information and Engineering Systems

2008 • 1,705 citations

Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases

2006 • 999 citations

Endogenous DNA damage in humans: a review of quantitative data

2004 • 978 citations

Oxidative Decay of DNA

1997 • 938 citations

DNA Repair, Genome Stability, and Aging

2005 • 895 citations

FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES

1963 • 801 citations

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

1999 • 792 citations

MGMT: its role in cancer aetiology and cancer therapeutics

2004 • 788 citations

JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor

2006 • 774 citations

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

2002 • 723 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Alkylation damage in DNA and RNA—repair mechanisms and medical significance

2004 • 613 citations

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

2003 • 611 citations

AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli

2002 • 590 citations

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

2001 • 504 citations

A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA

2006 • 453 citations

A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions.

1989 • 451 citations

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.

1982 • 398 citations

Reversal of DNA alkylation damage by two human dioxygenases

2002 • 392 citations

Mmh / Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice

2000 • 342 citations

hUNG2 Is the Major Repair Enzyme for Removal of Uracil from U:A Matches, U:G Mismatches, and U in Single-stranded DNA, with hSMUG1 as a Broad Specificity Backup

2002 • 330 citations

Signalling hypoxia by HIF hydroxylases

2005 • 326 citations

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer

2004 • 317 citations

DNA binding and nucleotide flipping by the human DNA repair protein AGT

2004 • 289 citations

Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA

1998 • 284 citations

Organic Chemistry of Nucleic Acids

1972 • 250 citations

Targeted Modulation of MGMT: Clinical Implications

2006 • 245 citations

Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli

2004 • 234 citations

Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase

1997 • 232 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Methylation-induced blocks to in vitro DNA replication

1985 • 220 citations

Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB

2006 • 220 citations

Escherichia coil,Saccharomyces cerevisiae, rat and human 3-methyladenine DNA glycosylases repair 1,N⁶-ethenoadenine when present in DNA

1995 • 208 citations

Methylation: lost in hydroxylation?

2005 • 203 citations

House cleaning, a part of good housekeeping

2005 • 203 citations

Direct Reversal of DNA Alkylation Damage

2006 • 201 citations

Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB

2003 • 198 citations

BRCA2-dependent and independent formation of RAD51 nuclear foci

2003 • 198 citations

AlkB Restores the Biological Function of mRNA and tRNA Inactivated by Chemical Methylation

2004 • 194 citations

Phase II Trial of Carmustine Plus O⁶-Benzylguanine for Patients With Nitrosourea-Resistant Recurrent or Progressive Malignant Glioma

2002 • 191 citations

Generation of a strong mutator phenotype in yeast by imbalanced base excision repair

1998 • 189 citations

AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo

2005 • 189 citations

Structure of a DNA Glycosylase Searching for Lesions

2006 • 189 citations

Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.

1996 • 186 citations

Bioinformatic mapping of AlkB homology domains in viruses

2005 • 181 citations

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

2006 • 179 citations

Release of normal bases from intact DNA by a native DNA repair enzyme

1998 • 176 citations

A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate

1983 • 175 citations

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage

2006 • 167 citations

Dissecting the Broad Substrate Specificity of Human 3-Methyladenine-DNA Glycosylase

2004 • 167 citations

Tissue distribution of S-adenosylmethionine and S-adenosylhomocysteine in the rat. Effect of age, sex and methionine administration on the metabolism of S-adenosylmethionine, S-adenosylhomocysteine and polyamines

1977 • 149 citations

Repair of DNA Methylphosphotriesters Through a Metalloactivated Cysteine Nucleophile

1993 • 149 citations

Recent progress on the Ada response for inducible repair of DNA alkylation damage

2002 • 144 citations

Repair of Methylation Damage in DNA and RNA by Mammalian AlkB Homologues

2005 • 138 citations

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

1998 • 132 citations

Defective processing of methylated single-stranded DNA by E. coli alkB mutants

2000 • 121 citations

Substrate specificities of bacterial and human AlkB proteins

2004 • 118 citations

ACCELERATED PAPER: Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

1996 • 116 citations

Alkylpurine–DNA–N-Glycosylase Knockout Mice Show Increased Susceptibility to Induction of Mutations by Methyl Methanesulfonate

1998 • 112 citations

Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway

2003 • 111 citations

Direct Repair of the Exocyclic DNA Adduct 1,N⁶-Ethenoadenine by the DNA Repair AlkB Proteins

2005 • 110 citations

Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins

2004 • 107 citations

Human Alkyladenine DNA Glycosylase Uses Acid−Base Catalysis for Selective Excision of Damaged Purines

2003 • 102 citations

Demethylation of 3-Methylthymine in DNA by Bacterial and Human DNA Dioxygenases

2004 • 99 citations

Escherichia coli gene that controls sensitivity to alkylating agents

1978 • 88 citations

The Selectivity and Inhibition of AlkB

2003 • 84 citations

Minimal Methylated Substrate and Extended Substrate Range of Escherichia coli AlkB Protein, a 1-Methyladenine-DNA Dioxygenase

2003 • 84 citations

High Expression of a New Marker PCA-1 in Human Prostate Carcinoma

2005 • 83 citations

Structure and transcriptional regulation of the Escherichia coli adaptive response gene aidB

1994 • 82 citations

Nitrosated peptides and polyamines as endogenous mutagens in O6- alkylguanine-DNA alkyltransferase deficient cells

1997 • 79 citations

The Non-Heme Diiron Alkane Monooxygenase of Pseudomonas oleovorans (AlkB) Hydroxylates via a Substrate Radical Intermediate

2000 • 78 citations

3-Methyladenine DNA glycosylase-deficient Aag null mice display unexpected bone marrow alkylation resistance.

2002 • 77 citations

Molecular Cloning and Functional Analysis of a Human cDNA Encoding an Escherichia Coli AlkB Homolog, a Protein Involved in DNA Alkylation Damage Repair

1996 • 77 citations

Methylated DNA-binding domain 1 and methylpurine–DNA glycosylase link transcriptional repression and DNA repair in chromatin

2003 • 77 citations

Interaction of Estrogen Receptor α with 3-Methyladenine DNA Glycosylase Modulates Transcription and DNA Repair

2004 • 74 citations

A Methylation-Dependent Electrostatic Switch Controls DNA Repair and Transcriptional Activation by E. coli Ada

2005 • 74 citations

The Escherichia coli AlkB protein protects human cells against alkylation-induced toxicity

1994 • 71 citations

A new protein superfamily includes two novel 3‐methyladenine DNA glycosylases from Bacillus cereus, AlkC and AlkD

2006 • 59 citations

Sensitization of Human Carcinoma Cells to Alkylating Agents by Small Interfering RNA Suppression of 3-Alkyladenine-DNA Glycosylase

2005 • 58 citations

Function of Domains of Human O⁶-Alkylguanine-DNA Alkyltransferase

2005 • 56 citations

Substrate Specificity of Human Methylpurine DNA N-Glycosylase

2000 • 55 citations

Mutagenesis by alkylating agents: Coding properties for DNA polymerase of poly (dC) template containing 3-methylcytosine

1982 • 46 citations

DNA repair by bacterial AlkB proteins

2003 • 44 citations

Influence of hydrogen bonding in DNA and polynucleotides on reaction of nitrogens and oxygens toward ethylnitrosourea

1979 • 44 citations

The AidB Component of the Escherichia coli Adaptive Response to Alkylating Agents Is a Flavin-Containing, DNA-Binding Protein

2005 • 36 citations

Chemical incorporation of 1-methyladenosine into oligonucleotides

2002 • 36 citations

Inhibition of O6-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli

2005 • 36 citations

Incorporation of oxygen into the succinate co‐product of iron(II) and 2‐oxoglutarate dependent oxygenases from bacteria, plants and humans

2005 • 35 citations

Gbp1p, a Protein with RNA Recognition Motifs, Binds Single-Stranded Telomeric DNA and Changes Its Binding Specificity upon Dimerization

1999 • 34 citations

An alkB gene homolog is differentially transcribed during the Caulobacter crescentus cell cycle

1997 • 30 citations

Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies

2004 • 28 citations

The solution structure of the methylated form of the N‐terminal 16‐kDa domain of Escherichia coli Ada protein

2006 • 27 citations

Direct Removal of Alkylation Damage from DNA by AlkB and Related DNA Dioxygenases

2006 • 26 citations

Gene silencing in phenomena related to DNA repair

2002 • 23 citations

AlkB dioxygenase in preventing MMS-induced mutagenesis in Escherichia coli: Effect of Pol V and AlkA proteins

2005 • 18 citations

Prediction of unidentified human genes on the basis of sequence similarity to novel cDNAs from cynomolgus monkey brain

2001 • 13 citations

Generalized Composite Motif Discovery

2005 • 6 citations