Phase II Trial of Carmustine Plus O⁶-Benzylguanine for Patients With Nitrosourea-Resistant Recurrent or Progressive Malignant Glioma

Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

2000 • 2,127 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint radiation therapy oncology group and eastern cooperative oncology group study

1983 • 600 citations

Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

1995 • 502 citations

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

1990 • 460 citations

Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma.

1983 • 394 citations

Clinically Significant Pharmacokinetic Drug Interactions with Carbamazepine

1996 • 327 citations

Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study.

1998 • 300 citations

Phase I Trial of Temozolomide Plus O⁶-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

2005 • 288 citations

Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine.

1996 • 245 citations

Repair of DNA containing O ⁶ ‐alkylguanine

1992 • 241 citations

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.

1991 • 229 citations

The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis

1985 • 224 citations

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.

1998 • 214 citations

O6-benzylguanine and its role in chemotherapy.

1997 • 214 citations

DNA alkylation by the haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair or removal

1990 • 213 citations

Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells.

1989 • 165 citations

Regulation of Repair of Alkylation Damage in Mammalian Genomes

1993 • 164 citations

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

1993 • 152 citations

DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas.

1980 • 151 citations

Therapy of adult malignant brain tumors: what have the clinical trials taught us?

1986 • 145 citations

O⁶-Alkylguanine-DNA alkyltransferase activity in human brain and brain tumors

1984 • 137 citations

The basis for current treatment recommendations for malignant gliomas

1994 • 135 citations

O6-Alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts

1989 • 122 citations

Phase I Trial of Carmustine Plus O6-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

2000 • 112 citations

Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.

1992 • 105 citations

Enhancement of Nitrosourea Activity in Medulloblastoma and Glioblastoma Multiforme

1992 • 102 citations

Chemotherapy of Primary Brain Tumors

1985 • 99 citations

Modulation of Mammalian O⁶-Alkylguanine-DNA Alkyltransferase in vivo by O⁶-Benzylguanine and its Effect on the Sensitivity of a Human Glioma Tumor to l-(2-chloroethyl)-3-(4-methylcyclohexyl)-l-nitrosourea

1990 • 95 citations

Cytochrome P450?inducing antiepileptics increase the clearance of vincristine in patients with brain tumors

1999 • 90 citations

Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines.

1990 • 87 citations

Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.

1986 • 86 citations

O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings.

1998 • 82 citations

Pretreatment of human colon tumor cells with DNA methylating agents inhibits their ability to repair chloroethyl monoadducts

1984 • 75 citations

O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.

2000 • 72 citations

Treatment of subcutaneous and intracranial brain tumor xenografts withO 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea

1993 • 70 citations

Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.

1985 • 69 citations

O6-Alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications

1994 • 68 citations

Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents.

1986 • 67 citations

Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione.

1989 • 64 citations

Potentiation of nitrosourea cytotoxicity in human leukemic cells by inactivation of O6-alkylguanine-DNA alkyltransferase.

1988 • 63 citations

Comparison of the inactivation of mammalian and bacterial O⁶-alkylguanine-DNA alkyltransferases by O⁶-benzylguanine and O⁶-methylguanine

1991 • 55 citations

Exposure of HeLa cells to 06-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents

1985 • 54 citations

Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.

1985 • 50 citations

Human liver oxidative metabolism of O6-benzylguanine

1995 • 47 citations

Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.

1999 • 46 citations

Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.

1994 • 45 citations

Cellular resistance to chloroethylnitrosoureas, nitrogen mustard, and cis-diamminedichloroplatinum(II) in human glial-derived cell lines.

1987 • 43 citations

Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine

1989 • 39 citations

Inhibition of O⁶-alkylguanine-DNA-alkyltransferase activity potentiates cytotoxicity and induction of SCEs in human glioma cells resistant to 1,3-bis(2-chloroethyl)-1-nitrosourea

1987 • 31 citations

Species differences in phenytoin induction of cytochrome P450 due to pharmacokinetic differences.

1984 • 3 citations