Alkylation damage in DNA and RNA—repair mechanisms and medical significance

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DNA Repair and Mutagenesis

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Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

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The Role of DNA Methylation in Mammalian Epigenetics

2001 • 1,956 citations

DNA and its associated processes as targets for cancer therapy

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The Composite Genome of the Legume Symbiont Sinorhizobium meliloti

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Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

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DNA glycosylases in the base excision repair of DNA

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Molecular Biology of Mutagens and Carcinogens

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The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58

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Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

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2001 • 642 citations

Genome Sequence of the Plant Pathogen and Biotechnology Agent Agrobacterium tumefaciens C58

2001 • 641 citations

A mammalian protein with specific demethylase activity for mCpG DNA

1999 • 624 citations

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

2003 • 611 citations

AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli

2002 • 590 citations

Mechanisms of human DNA repair: an update

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Repair of O6-alkylguanine by alkyltransferases

2000 • 569 citations

The interacting pathways for prevention and repair of oxidative DNA damage

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Repair of DNA interstrand cross-links

2001 • 554 citations

The base excision repair pathway

1995 • 536 citations

Comparative genomics and evolution of proteins involved in RNA metabolism

2002 • 524 citations

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

2001 • 504 citations

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

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Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

Structure of isopenicillinN synthase complexed with substrate and the mechanism ofpenicillin formation

1997 • 426 citations

Clinical Relevance of MGMT in the Treatment of Cancer

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Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.

1982 • 398 citations

Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer

2002 • 394 citations

Reversal of DNA alkylation damage by two human dioxygenases

2002 • 392 citations

Estimation of Divergence Times for Major Lineages of Primate Species

2003 • 383 citations

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

1999 • 382 citations

Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance

2001 • 373 citations

Using <tt>GeneWise</tt> in the Drosophila Annotation Experiment

2000 • 368 citations

DNA adduct formation from tobacco-specific N-nitrosamines

1999 • 365 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

Structure of a cephalosporin synthase

1998 • 337 citations

Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis thaliana

2002 • 335 citations

Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study.

1998 • 300 citations

The complete sequence of the 1,683-kb pSymB megaplasmid from the N ₂ -fixing endosymbiont Sinorhizobium meliloti

2001 • 299 citations

Adaptation to alkylation resistance involves the induction of a DNA glycosylase

1982 • 283 citations

DNA Repair: Enzymatic Mechanisms and Relevance to Drug Response

1996 • 280 citations

Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice

1997 • 277 citations

New class of enzymes acting on damaged DNA

1976 • 259 citations

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.

2000 • 259 citations

Structure-based analysis of protein-RNA interactions using the program ENTANGLE

2001 • 242 citations

The Prevention of Thymic Lymphomas in Transgenic Mice by Human O ⁶ -Alkylguanine-DNA Alkyltransferase

1993 • 238 citations

Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

1982 • 227 citations

Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG

2000 • 221 citations

Repair Kinetics of Genomic Interstrand DNA Cross-Links: Evidence for DNA Double-Strand Break-Dependent Activation of the Fanconi Anemia/BRCA Pathway

2003 • 218 citations

X-ray Crystal Structure of Escherichia coli Taurine/α-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates^,

2002 • 216 citations

O6-benzylguanine and its role in chemotherapy.

1997 • 214 citations

More Characters or More Taxa for a Robust Phylogeny—Case Study from the Coffee Family (Rubiaceae)

1999 • 208 citations

Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed dose-response study.

1991 • 207 citations

Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine

2002 • 200 citations

Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB

2003 • 198 citations

Chloride Methylation by Plant Pectin: An Efficient Environmentally Significant Process

2003 • 197 citations

Fanconi anemia and DNA repair

2001 • 194 citations

3-methyladenine DNA glycosylases: structure, function, and biological importance

1999 • 194 citations

Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.

1996 • 186 citations

Variability and regulation of O6-alkylguanine-DNA alkyltransferase

2003 • 183 citations

O⁶‐alkylguanine‐DNA alkyltransferase: Role in carcinogenesis and chemotherapy

2002 • 182 citations

Volatile organic compounds in some urban locations in United States

2002 • 178 citations

Release of normal bases from intact DNA by a native DNA repair enzyme

1998 • 176 citations

A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate

1983 • 175 citations

NCBI Reference Sequence Project: update and current status

2003 • 175 citations

Structural genomics: A pipeline for providing structures for the biologist

2002 • 170 citations

Dissecting the Broad Substrate Specificity of Human 3-Methyladenine-DNA Glycosylase

2004 • 167 citations

Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells

2004 • 163 citations

Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro

1982 • 161 citations

Generation of an endogenous DNA-methylating agent by nitrosation in Escherichia coli

1996 • 155 citations

Challenging Dogma: Thresholds for Genotoxic Carcinogens? The Case of Vinyl Acetate

2003 • 155 citations

Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide

2003 • 154 citations

Deficiency in Protein l-Isoaspartyl Methyltransferase Results in a Fatal Progressive Epilepsy

1998 • 147 citations

DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

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Recent progress on the Ada response for inducible repair of DNA alkylation damage

2002 • 144 citations

A system in mouse liver for the repair of O⁶-methylguanine lesions in methylated DNA

1981 • 137 citations

Pattern and sources of naturally produced organohalogens in the marine environment: biogenic formation of organohalogens

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1998 • 132 citations

Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.

1997 • 130 citations

O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.

1999 • 127 citations

A Chemical and Genetic Approach Together Define the Biological Consequences of 3-Methyladenine Lesions in the Mammalian Genome

1998 • 126 citations

Base excision repair as a therapeutic target in colon cancer.

2002 • 123 citations

Defective processing of methylated single-stranded DNA by E. coli alkB mutants

2000 • 121 citations

Food Mutagens

2003 • 117 citations

RNA surveillance by nuclear scanning?

2002 • 114 citations

Alkylpurine–DNA–N-Glycosylase Knockout Mice Show Increased Susceptibility to Induction of Mutations by Methyl Methanesulfonate

1998 • 112 citations

Early Formation of mRNP

2003 • 111 citations

Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway

2003 • 111 citations

Structure of proline 3‐hydroxylase

2001 • 107 citations

Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.

1986 • 107 citations

Interindividual variation in the activity of O⁶-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs

1983 • 102 citations

Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases.

1991 • 101 citations

Nitrosated glycine derivatives as a potential source of O6-methylguanine in DNA.

1997 • 96 citations

Contribution of Base Excision Repair, Nucleotide Excision Repair, and DNA Recombination to Alkylation Resistance of the Fission Yeast Schizosaccharomyces pombe

2000 • 95 citations

Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene.

1991 • 94 citations

BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis

2001 • 94 citations

High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase

1997 • 93 citations

Hypersensitivity of DNA polymerase β null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions

2002 • 90 citations

Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O6-alkylguanine-DNA alkyltransferase

2000 • 80 citations

Probing the Energetic and Structural Role of Amino Acid/Nucleobase Cation-π Interactions in Protein-Ligand Complexes

2002 • 80 citations

Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone

1983 • 79 citations

Mechanistic studies of 1-aminocyclopropane-1-carboxylic acid oxidase: single turnover reaction

2004 • 78 citations

Molecular Cloning and Functional Analysis of a Human cDNA Encoding an Escherichia Coli AlkB Homolog, a Protein Involved in DNA Alkylation Damage Repair

1996 • 77 citations

3-Methyladenine DNA glycosylase-deficient Aag null mice display unexpected bone marrow alkylation resistance.

2002 • 77 citations

Identification of the cross-link between human O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea-treated DNA.

1992 • 76 citations

Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes

2002 • 76 citations

The Escherichia coli gabDTPC Operon: Specific γ-Aminobutyrate Catabolism and Nonspecific Induction

2002 • 75 citations

New Sources of Dietary Myosmine Uptake from Cereals, Fruits, Vegetables, and Milk

2002 • 73 citations

Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing.

2003 • 72 citations

Mechanisms of Carcinogenicity of Methyl Halides

1993 • 72 citations

The Escherichia coli AlkB protein protects human cells against alkylation-induced toxicity

1994 • 71 citations

Lack of a Dose‐response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline or N‐Nitrosodiethylamine

2002 • 70 citations

Imbalanced Base Excision Repair Increases Spontaneous Mutation and Alkylation Sensitivity in Escherichia coli

1999 • 67 citations

Molecular cloning and characterization of the alkB gene of Escherichia coli

1985 • 66 citations

Mismatch repair and differential sensitivity of mouse and human cells to methylating agents

1999 • 64 citations

Interaction of the recombinant human methylpurine-DNA glycosylase (MPG protein) with oligodeoxyribonucleotides containing either hypoxanthine or abasic sites

1998 • 62 citations

Imatinib sensitizes CLL lymphocytes to chlorambucil

2003 • 59 citations

The molecular basis for biological inactivation of nucleic acids. The action of methylating agents on the ribonucleic acid-containing bacteriophage R17

1974 • 59 citations

Genotoxicity—threshold or not? Introduction of cases of industrial chemicals

2003 • 59 citations

DNA Alkylation and Repair in the Large Bowel: Animal and Human Studies

2002 • 58 citations

Carcinogenicity in rats of the nitrosated bile acid conjugates N-nitrosoglycocholic acid and N-nitrosotaurocholic acid.

1985 • 58 citations

Structure and expression of the alkB gene of Escherichia coli related to the repair of alkylated DNA.

1986 • 58 citations

Molecular mechanisms of adaptive response to alkylating agents in Escherichia coli and some remarks on O6-methylguanine DNA-methyltransferase in other organisms

2002 • 56 citations

Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase

1993 • 53 citations

Mammalian DNA repair methyltransferases shield O4MeT from nucleotide excision repair

1997 • 52 citations

Probing the Structure and Function of theEscherichia coliDNA Alkylation Repair AlkB Protein through Chemical Cross-Linking

2003 • 51 citations

Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite

1997 • 46 citations

Processing of O6-methylguanine by mismatch correction in human cell extracts

1996 • 45 citations

DNA repair by bacterial AlkB proteins

2003 • 44 citations

DNA repair inhibition and cancer therapy

2001 • 43 citations

Amino Acid Nitrosation Products as Alkylating Agents

2001 • 42 citations

Hijacking of the Human Alkyl-N-purine-DNA Glycosylase by 3,N4-Ethenocytosine, a Lipid Peroxidation-induced DNA Adduct

2004 • 40 citations

Constitutive expression and inducibility of O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in rat liver cells exhibiting different status of differentiation

1995 • 39 citations

Relationship between O6-methylguanine-DNA methyltransferase levels and clinical response induced by chloroethylnitrosourea therapy in glioma patients.

1999 • 38 citations

Organization and expression of the human gene for O^6-methylguanine-DNA methyltransferase

1993 • 36 citations

Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N′-nitro-N-nitrosoguanidine

1999 • 35 citations

Novel aspects of macromolecular repair and relationship to human disease

2004 • 35 citations

Gbp1p, a Protein with RNA Recognition Motifs, Binds Single-Stranded Telomeric DNA and Changes Its Binding Specificity upon Dimerization

1999 • 34 citations

Repair of O⁶‐methyl‐guanine residues in DNA takes place by a similar mechanism in extracts from hela cells, human liver, and rat liver

1982 • 33 citations

Deficient Regulation of DNA Double-strand Break Repair in Fanconi Anemia Fibroblasts

2003 • 32 citations

A multidrug combination designed for reversing resistance to BCNU in glioblastoma multiforme

2002 • 32 citations

Effect of chronic ethanol diet on the replication, alkylation, and repair of DNA from hepatocytes and nonparenchymal cells following dimethylnitrosamine administration

1982 • 31 citations

An alkB gene homolog is differentially transcribed during the Caulobacter crescentus cell cycle

1997 • 30 citations

Different efficiencies of the Tag and AlkA DNA glycosylases from Escherichia coli in the removal of 3‐methyladenine from single‐stranded DNA

1996 • 30 citations

Differential capacities for DNA repair in Clara cells, alveolar type II cells and macrophages of rabbit lung

1985 • 29 citations

Threshold for carcinogenicity of N-nitrosodiethylamine for esophageal tumors in rats

2003 • 27 citations

Induction of the adaptive response of Escherichia coli to alkylation damage by the environmental mutagen, methyl chloride

1993 • 26 citations

Expression in mammalian cells of the Escherichia coli O6 alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas

1993 • 21 citations

Characterization of a novel reaction by human O6-alkylguanine-DNA alkyltransferase with 1,3-bis(2-chloroethyl)-1-nitrosourea-treated DNA.

1987 • 21 citations

Effect of alkyl-N-purine DNA glycosylase overexpression on cellular resistance to bifunctional alkylating agents

1995 • 21 citations

Prediction of unidentified human genes on the basis of sequence similarity to novel cDNAs from cynomolgus monkey brain

2001 • 13 citations

New drugs and combinations for malignant glioma.

2003 • 12 citations

DNA Repair: Bioinformatics Helps Reverse Methylation Damage

2002 • 9 citations

Nuclear structure and intranuclear retention of premature RNAs

2002 • 6 citations

A new damage limitation exercise: ironing (Fe(II)) out minor DNA methylation lesions

2002 • 6 citations

The role of human alkyladenine glycosylase in cellular resistance to the chloroethylnitrosoureas

2003 • 5 citations

Dose-threshold for thyroid tumor-promoting effects of xylazine in rats

2003 • 2 citations