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The CpG dinucleotide and human genetic disease

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Cancer risk and oxidative DNA damage in man

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DNA Repair Enzymes

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Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.

1991 • 784 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators

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DNA REPAIR IN EUKARYOTES

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Molecular Mechanisms of Estrogen Carcinogenesis

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5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

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DNA end-joining: from yeast to man

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Is Estradiol a Genotoxic Mutagenic Carcinogen?1

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Detection of Endogenous Malondialdehyde-Deoxyguanosine Adducts in Human Liver

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Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts

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Possible mutagens derived from lipids and lipid precursors

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Cytosine methylation determines hot spots of DNA damage in the human P 53 gene

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A method for detecting abasic sites in living cells: Age-dependent changes in base excision repair

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Molecular Epidemiology: Insights Into Cancer Susceptibility, Risk Assessment, and Prevention

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Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage

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Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases.

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Is Estradiol a Genotoxic Mutagenic Carcinogen?

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Induction of microsatellite instability by oxidative DNA damage

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DNA mismatch repair and cancer

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1994 • 217 citations

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DNA REPAIR IN HUMANS

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Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells.

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Molecular Characteristics of Catechol Estrogen Quinones in Reactions with Deoxyribonucleosides

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Mutation frequency and spectrum resulting from a single abasic site in a single-stranded vector

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Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA.

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Susceptibility of Glutathione Peroxidase and Glutathione Reductase to Oxidative Damage and the Protective Effect of Spin Trapping Agents

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Cigarette Smoking Induces Formation of 8-Hydroxydeoxyguanosine, One of the Oxidative Dna Damages in Human Peripheral Leukocytes

1990 • 182 citations

1,N⁶-Ethenodeoxyadenosine, a DNA Adduct Highly Mutagenic in Mammalian Cells

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Hypoxanthine in deoxyribonucleic acid: generation by heat-induced hydrolysis of adenine residues and release in free form by a deoxyribonucleic acid glycosylase from calf thymus

1980 • 177 citations

Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide.

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Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal

1998 • 175 citations

Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole

1993 • 174 citations

RESPONSE: Re: Relationship Between p53 Mutations and Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer

1999 • 172 citations

Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers

1998 • 167 citations

Relationship Between p53 Mutations and Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer

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The Complex Chemistry of Peroxynitrite Decomposition: New Insights¹

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Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairingin vitro

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Deoxyguanosine adducts of t-4-hydroxy-2-nonenal are endogenous DNA lesions in rodents and humans: detection and potential sources.

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Mutagenicity in Escherichia coli of the major DNA adduct derived from the endogenous mutagen malondialdehyde

1997 • 149 citations

All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.

1994 • 148 citations

In vivo accumulation of 8-hydroxy-2'-deoxyguanosine in DNA correlates with release of reactive oxygen species in Fanconi's anaemia families

1995 • 146 citations

Activated Leukocytes Oxidatively Damage DNA, RNA, and the Nucleotide Pool through Halide-Dependent Formation of Hydroxyl Radical

2000 • 145 citations

Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots.

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Ultrasensitive and specific detection methods for exocylic DNA adducts: Markers for lipid peroxidation and oxidative stress

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Endogenous genotoxic agents and processes as a basis of spontaneous carcinogenesis

1990 • 138 citations

Synthesis and characterization of estrogen 2,3- and 3,4-quinones. Comparison of DNA adducts formed by the quinones versus horseradish peroxidase-activated catechol estrogens

1992 • 134 citations

Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.

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Determination of DNA adducts of malonaldehyde in humans: effects of dietary fatty acid composition

1996 • 132 citations

1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal.

1988 • 129 citations

High dietary omega-6 polyunsaturated fatty acids drastically increase the formation of etheno-DNA base adducts in white blood cells of female subjects.

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1,N2-propanodeoxyguanosine adducts: potential new biomarkers of smoking-induced DNA damage in human oral tissue.

1998 • 126 citations

DNA damage by carbonyl stress in human skin cells

2003 • 126 citations

Detection of 1, N2-propanodeoxyguanosine adducts as potential endogenous DNA lesions in rodent and human tissues.

1996 • 124 citations

The vinyl chloride DNA derivative N2,3-ethenoguanine produces G----A transitions in Escherichia coli.

1991 • 118 citations

Site-specific mutagenesis in vivo by single methylated or deaminated purine bases

1986 • 118 citations

5′-Nicked Apurinic/Apyrimidinic Sites Are Resistant to β-Elimination by β-Polymerase and Are Persistent in Human Cultured Cells after Oxidative Stress

2000 • 115 citations

On the Role of DNA Double-Strand Breaks in Toxicity and Carcinogenesis

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An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: a comparison of four datasets

1994 • 111 citations

Internal hazards: baseline DNA damage by endogenous products of normal metabolism

1999 • 111 citations

Oxidative DNA Damage: Endogenous and Chemically Induced

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Analysis of the Malondialdehyde−2‘- Deoxyguanosine Adduct Pyrimidopurinone in Human Leukocyte DNA by Gas Chromatography/Electron Capture/Negative Chemical Ionization/Mass Spectrometry

1997 • 110 citations

1,N 2-Ethenoguanine, a Mutagenic DNA Adduct, Is a Primary Substrate of Escherichia coliMismatch-specific Uracil-DNA Glycosylase and Human Alkylpurine-DNA-N-Glycosylase

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Glutathione and ascorbate are negatively correlated with oxidative DNA damage in human lymphocytes

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Comparison of DNA adduct levels associated with oxidative stress in human pancreas

1998 • 103 citations

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1991 • 99 citations

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Mitochondrial endogenous oxidative damage has been overestimated

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Unsaturated lipids and intestinal bacteria as sources of endogenous production of ethene and ethylene oxide

1989 • 94 citations

Accumulation of 8-oxo-2′-deoxyguanosine and increased expression of hMTH1 protein in brain tumors

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The Croonian Lecture, 1996: Endogenous damage to DNA

1996 • 88 citations

Oxidative DNA Damage in Human Respiratory Tract Epithelial Cells. Time Course in Relation to DNA Strand Breakage

1996 • 86 citations

Formation of Cyclic Deoxyguanosine Adducts from ω-3 and ω-6 Polyunsaturated Fatty Acids under Oxidative Conditions

2002 • 83 citations

Smoking-related DNA adducts: ³²P-postlabeling analysis of 7-methylguanine in human bronchial and lymphocyte DNA

1993 • 82 citations

A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3, N ⁴ -ethenocytosine and the G/T mismatch

1998 • 81 citations

Single Nucleotide Patch Base Excision Repair Is the Major Pathway for Removal of Thymine Glycol from DNA in Human Cell Extracts

2000 • 80 citations

Formation of DNA adducts in human buccal epithelial cells exposed to acetaldehyde and methylglyoxal in vitro

1998 • 80 citations

7-Methylguanine levels in DNA of smokers' and non-smokers' total white blood cells, granulocytes and lymphocytes

1992 • 78 citations

Etheno adducts in spleen DNA of SJL mice stimulated to overproduce nitric oxide

1998 • 78 citations

DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer

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Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells

1997 • 76 citations

Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation

2001 • 74 citations

Reactivity and Mutagenicity of Endogenous DNA Oxopropenylating Agents: Base Propenals, Malondialdehyde, and N^ε-Oxopropenyllysine

2000 • 73 citations

Heterogeneous repair of N -methylpurines at the nucleotide level in normal human cells 1 1Edited by M. Yahiv

1998 • 71 citations

Quantification of Etheno-DNA Adducts Using Liquid Chromatography, On-Line Sample Processing, and Electrospray Tandem Mass Spectrometry

2000 • 70 citations

Synergistic Induction of DNA Strand Breakage by Catechol-Estrogen and Nitric Oxide

1998 • 70 citations

Role of Endogenous Oxidative DNA Damage in Carcinogenesis: What Can We Learn from Repair-Deficient Mice?

2002 • 69 citations

Oestrogen-Induced Enhancement of Myeloperoxidase Activity in Human Polymorphonuclear Leukocytes-A Possible Cause of Oxidative Stress in Inflammatory Cells

1991 • 68 citations

³²P-Postlabelling determination of DNA adducts of malonadlehyde in humans: total white blood cells and breast tissue

1995 • 67 citations

Biological properties of imidazole ring-opened N7-methylguanine in M13mp18 phage DNA

1992 • 67 citations

O4-Methyl, -ethyl, or -isopropyl substituents on thymidine in poly(dA-dT) all lead to transitions upon replication.

1986 • 66 citations

Dose-response relationships for carcinogens

1995 • 66 citations

Cancer risk and oxidative DNA damage in man

1997 • 65 citations

Mutagenicity of Site-Specifically Located 1,N²-Ethenoguanine in Chinese Hamster Ovary Cell Chromosomal DNA

1999 • 64 citations

A discussion of mechanisms of NO genotoxicty: Implication of inhibition of DNA repair proteins

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DNA mismatch repair and cancer

1998 • 63 citations

Oxy-Radicals and Related Species: Their Formation, Lifetimes, and Reactions

1986 • 63 citations

Mutagenic properties of a unique abasic site in mammalian cells

1990 • 62 citations

Molecular Mechanisms of Estrogen Carcinogenesis

1996 • 62 citations

Detection and Quantification of 1,N⁶-Ethenoadenine in Human Placental DNA by Mass Spectrometry

1999 • 61 citations

Misincorporation of dNTPs Opposite 1,N²-Ethenoguanine and 5,6,7,9-Tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in Oligonucleotides by Escherichia coli Polymerases I exo^- and II exo^-, T7 Polymerase exo^-, Human Immunodeficiency Virus-1 Reverse Transcriptase, and Rat Polymerase β

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Endogenous and background DNA adducts by methylating and 2-hydroxyethylating agents

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Synthesis, Stability, and Conformation of the Formamidopyrimidine G DNA Lesion

2002 • 59 citations

Aberrant Processing of Oxidative DNA Damage in Systemic Lupus Erythematosus

2000 • 59 citations

The O-methylation of 4-hydroxyestradiol is inhibited by 2-hydroxyestradiol: implications for estrogen-induced carcinogenesis

1990 • 58 citations

Formation of the 1,N2-Glyoxal Adduct of Deoxyguanosine by Phosphoglycolaldehyde, a Product of 3‘-Deoxyribose Oxidation in DNA

2001 • 57 citations

DNA Adducts: Endogenous and Induced

2000 • 57 citations

Detection of O⁶-methylguanine, O⁴-methylthymine and O⁴-ethylthymine in human liver and peripheral blood leukocyte DNA

1995 • 53 citations

Spectrum of somatic mutation at the hypoxanthine phosphoribosyltransferase (hprt) gene of healthy people

1996 • 52 citations

Repair of abasic sites by mammalian cell extracts

1994 • 48 citations

Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors

2001 • 47 citations

Mutagenesis by alkylating agents: Coding properties for DNA polymerase of poly (dC) template containing 3-methylcytosine

1982 • 46 citations

Distribution of 7-alkyl-2'-deoxyguanosine adduct levels in human lung

1996 • 45 citations

In vitro miscoding of alkylthymines with DNA and RNA polymerases

1985 • 45 citations

Keynote address: exocyclic adducts as new risk markers for DNA damage in man.

1999 • 45 citations

Tobacco smoke-associated N7-alkylguanine in DNA of larynx tissue and leucocytes

1996 • 43 citations

Quantitative Analysis of the DNA AdductN2,3-Ethenoguanine Using Liquid Chromatography/Electrospray Ionization Mass Spectrometry

1996 • 41 citations

Endogenous DNA Lesions Can Inhibit the Binding of the AP-1 (c-Jun) Transcription Factor

2002 • 41 citations

Comparative analysis of 8-oxo-2' -deoxyguanosine in DNA by 32P- and 33P- postlabeling and electrochemical detection

1997 • 41 citations

Mechanisms of Formation of Adducts from Reactions of Glycidaldehyde with 2‘-Deoxyguanosine and/or Guanosine

1996 • 37 citations

Separation of 7-methyl- and 7-(2-hydroxyethyl)-guanine adducts in human DNA samples using a combination of TLC and HPLC

1996 • 37 citations

Inverse correlation between alcohol consumption and lymphocyte levels of 8-hydroxydeoxyguanosine in humans

2001 • 37 citations

Spectrum of point mutations in the coding region of the hypoxanthine- guanine phosphoribosyltransferase (hprt) gene in human T-lymphocytes in vivo

1998 • 37 citations

Spectra of superoxide-induced mutations in the lacI gene of a wild-type and a mutM strain of Escherichia coli K-12

1995 • 35 citations

DNA damage at thymine N-3 abolishes base-pairing capacity during DNA synthesis.

1987 • 34 citations

The cytotoxicity of DNA carboxymethylation and methylation by the model carboxymethylating agent azaserine in human cells

1999 • 33 citations

Development and Application of a Sensitive and Rapid Immunoassay for the Quantitation of N7-Methyldeoxyguanosine in DNA Samples

2001 • 33 citations

Quantification of 7-methyldeoxyguanosine using immunoaffinity purification and HPLC with electrochemical detection

1993 • 31 citations

Ring-extended products from the reaction of epoxy carbonyl compounds and nucleic acid bases

1985 • 30 citations

Generation of Single-Nucleotide Repair Patches Following Excision of Uracil Residues from DNA

1992 • 30 citations

The in vivo levels of DNA alkylation products in human lymphocytes are not age dependent: an assay of 7-methyl- and 7-(2-hydroxyethyl)-guanine DNA adducts

2002 • 29 citations

The causes of cancer. Quantitative estimates of avoidable risk of cancer in the United States today

1983 • 29 citations

Comparison of various immunochemical assays for the detection of ethylene oxide-DNA adducts with monoclonal antibodies against imidazole ring-opened N7-(2-hydroxyethyl)guanosine: application in a biological monitoring study

1994 • 27 citations

An Improved ³²P-Postlabeling/High-Performance Liquid Chromatography Method for the Analysis of the Malondialdehye-Derived 1,N²-Propanodeoxyguanosine DNA Adduct in Animal and Human Tissues

1998 • 27 citations

Novel Monoclonal Antibody Recognition of Oxidative DNA Damage Adduct, Deoxycytidine-Glyoxal

2003 • 26 citations

Carcinogenesis: Mutations and Mutagens

2001 • 23 citations

Differences in the promutagenic nature of 3-methylcytosine as revealed by DNA and RNA polymerising enzymes

1984 • 21 citations

Gene silencing and endogenous DNA methylation in mammalian cells

1998 • 20 citations

Inter-Individual Variations in Carcinogen Metabolism

1986 • 12 citations

Purine DNA adducts of 4,5-dioxovaleric acid and 2,4-decadienal.

1999 • 11 citations

Position- and base pair-specific comparison of p53 mutation spectra in human tumors: elucidation of relationships between organs for cancer etiology.

1998 • 7 citations

Solution conformation and mutagenic specificity of 1,N6-ethenoadenine.

1999 • 7 citations

Quantitative Analysis of the DNA Adduct N2,3- Ethenoguanine Using Liquid Chromatography Electrospray Ionization Mass Spectrometry

1996 • 4 citations

5′-Nicked Apurinic/Apyrimidinic Sites Are Resistant to β-Elimination by β-Polymerase and Are Persistent in Human Cultured Cells after Oxidative Stress

2000 • 1 citations