The Escherichia coli AlkB protein protects human cells against alkylation-induced toxicity

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Biology of Mutagens and Carcinogens

1983 • 803 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells.

1984 • 685 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

1970 • 500 citations

Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eucaryotic cells.

1984 • 258 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Transfection and expression of human O⁶-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

1991 • 219 citations

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase

1991 • 187 citations

A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate

1983 • 175 citations

Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16.

1991 • 132 citations

Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA

1990 • 130 citations

Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene.

1986 • 125 citations

Cloning a eukaryotic DNA glycosylase repair gene by the suppression of a DNA repair defect in Escherichia coli.

1989 • 124 citations

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.

1986 • 115 citations

Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.

1990 • 96 citations

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

1980 • 95 citations

The suicidal DNA repalr methyltransferases of microbes

1992 • 94 citations

Hygromycin B Phosphotransferase as a Selectable Marker for DNA Transfer Experiments with Higher Eucaryotic Cells

1984 • 94 citations

Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene.

1986 • 82 citations

Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents.

1984 • 82 citations

The Role of O6-Methylguanine in Human Cell Killing, Sister Chromatid Exchange Induction and Mutagenesis: A Review

1987 • 78 citations

A second DNA methyltransferase repair enzyme in Escherichia coli.

1988 • 77 citations

Transfer of the E. coli O6-methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N′-nitro-N-nitrosoguanidine

1986 • 67 citations

Molecular cloning and characterization of the alkB gene of Escherichia coli

1985 • 66 citations

Structure and expression of the alkB gene of Escherichia coli related to the repair of alkylated DNA.

1986 • 58 citations

Resistance to alkylation damage in Escherichia coli: Role of the Ada protein in induction of the adaptive response

1990 • 51 citations

Genetic complementation of UV-induced DNA repair in Chinese hamster ovary cells by the denV gene of phage T4.

1985 • 47 citations

TheSaccharomyces cerevisiae MGT1DNA repair methyltransferease gene: its promoter and entire coding sequence, regulation andin vivobiological functions

1992 • 42 citations

Transient and stable complementation of ultraviolet repair in xeroderma pigmentosum cells by the denV gene of bacteriophage T4.

1987 • 37 citations

DNA alkylation repair and the induction of cell death and sister chromatid exchange in human cells

1987 • 34 citations

The repair of DNA alkylation damage by methyltransferases and glycosylases.

1992 • 26 citations

Eukaryotic promoters drive gene expression in Escherichia coli

1989 • 25 citations

Transfectant CHO cells expressing O⁶-alkylguanine-DNA-alkyltransferase display increased resistance to DNA damage other than O⁶-guanine alkylation

1987 • 25 citations

Expression in mammalian cells of the Escherichia coli O6 alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas

1993 • 21 citations

Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes.

1992 • 19 citations

Molecular analysis of the aidD6: : Mu dl (bla lac) fusion mutation of Escherichia coli K12

1991 • 12 citations

denV gene of bacteriophage T4 restores DNA excision repair to mei-9 and mus201 mutants of Drosophila melanogaster.

1989 • 10 citations