Repair of Methylation Damage in DNA and RNA by Mammalian AlkB Homologues

Molecular Biology of Mutagens and Carcinogens

1983 • 803 citations

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

2002 • 723 citations

Alkylation damage in DNA and RNA—repair mechanisms and medical significance

2004 • 613 citations

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

2003 • 611 citations

AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli

2002 • 590 citations

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

2001 • 504 citations

Reversal of DNA alkylation damage by two human dioxygenases

2002 • 392 citations

Methyl-directed repair of DNA base-pair mismatches in vitro.

1983 • 344 citations

Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli

2004 • 234 citations

Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB

2003 • 198 citations

AlkB Restores the Biological Function of mRNA and tRNA Inactivated by Chemical Methylation

2004 • 194 citations

A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate

1983 • 175 citations

Functionality of Human Thymine DNA Glycosylase Requires SUMO-Regulated Changes in Protein Conformation

2005 • 161 citations

Recent progress on the Ada response for inducible repair of DNA alkylation damage

2002 • 144 citations

Defective processing of methylated single-stranded DNA by E. coli alkB mutants

2000 • 121 citations

Substrate specificities of bacterial and human AlkB proteins

2004 • 118 citations

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.

1986 • 115 citations

Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction.

1987 • 109 citations

Adaptive response of escherichia coli to alkylation damage

1988 • 108 citations

O₂- and α-Ketoglutarate-Dependent Tyrosyl Radical Formation in TauD, an α-Keto Acid-Dependent Non-Heme Iron Dioxygenase

2003 • 106 citations

Demethylation of 3-Methylthymine in DNA by Bacterial and Human DNA Dioxygenases

2004 • 99 citations

A novel fluorometric oligonucleotide assay to measure O 6-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase

2001 • 91 citations

Inactivation of mammalian 8-oxoguanine-DNA glycosylase by cadmium(II): implications for cadmium genotoxicity

2002 • 88 citations

Molecular Biology of Mutagens and Carcinogens

1984 • 87 citations

The Selectivity and Inhibition of AlkB

2003 • 84 citations

Minimal Methylated Substrate and Extended Substrate Range of Escherichia coli AlkB Protein, a 1-Methyladenine-DNA Dioxygenase

2003 • 84 citations

RNA Repair: Damage Control

2003 • 80 citations

Molecular Cloning and Functional Analysis of a Human cDNA Encoding an Escherichia Coli AlkB Homolog, a Protein Involved in DNA Alkylation Damage Repair

1996 • 77 citations

The Escherichia coli AlkB protein protects human cells against alkylation-induced toxicity

1994 • 71 citations

Molecular cloning and characterization of the alkB gene of Escherichia coli

1985 • 66 citations

Interaction of the recombinant human methylpurine-DNA glycosylase (MPG protein) with oligodeoxyribonucleotides containing either hypoxanthine or abasic sites

1998 • 62 citations

Structure and expression of the alkB gene of Escherichia coli related to the repair of alkylated DNA.

1986 • 58 citations

Aberrant activity of the DNA repair enzyme AlkB

2003 • 53 citations

Interconversion of two oxidized forms of taurine/α-ketoglutarate dioxygenase, a non-heme iron hydroxylase: Evidence for bicarbonate binding

2003 • 51 citations

AP site structural determinants for Fpg specific recognition

1999 • 50 citations

DNA damage recognition and repair by the murine MutY homologue

2004 • 47 citations

The stability of methyl and ethyl phosphotriesters in DNA in vivo

1977 • 46 citations

AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism

2003 • 41 citations

Expression of DNA damage-inducible genes of Escherichia coli upon treatment with methylating, ethylating and propylating agents

1989 • 37 citations

Succinate Complex Crystal Structures of the α-Ketoglutarate-dependent Dioxygenase AtsK

2004 • 34 citations

Repair in Escherichia coli alkB mutants of abasic sites and 3-methyladenine residues in DNA

1998 • 31 citations

Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies

2004 • 28 citations

Induction of the alkylation-inducible aidB gene of Escherichia coli by anaerobiosis

1989 • 14 citations

An assay for 0⁶-alkylguanine-DNA alkyltransferase based on restriction endonuclease inhibition and magnetic bead separation of products

1994 • 14 citations

Assay for O6-alkylguanine-DNA-alkyltransferase using oligonucleotides containing O6-methylguanine in a BamHI recognition site as substrate

1992 • 13 citations

A new damage limitation exercise: ironing (Fe(II)) out minor DNA methylation lesions

2002 • 6 citations

Methylation of μ2 bacteriophage ribonucleic acid by the carcinogen N-methyl-N-nitrosourea: evidence for O-methylation

1971 • 5 citations

Methods and problems in the study of plasma triglyceride metabolism in man

1971 • 1 citations