The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

Genetic studies of the lac repressor

1977 • 610 citations

Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

1970 • 500 citations

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

1974 • 495 citations

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate

1968 • 378 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas.

1977 • 297 citations

Mutagenesis of the replication point by nitrosoguanidine: Map and pattern of replication of the Escherichia coli chromosome

1968 • 297 citations

Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents

1982 • 287 citations

Induction of Closely Linked Multiple Mutations by Nitrosoguanidine

1971 • 284 citations

Adaptation to alkylation resistance involves the induction of a DNA glycosylase

1982 • 283 citations

N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.

1979 • 276 citations

The properties of in templates for RNA polymerase

1973 • 264 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by

1979 • 247 citations

Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification

1980 • 234 citations

Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

1982 • 227 citations

An adaptive response of E. coli to low levels of alkylating agent: Comparison with previously characterised DNA repair pathways

1977 • 225 citations

Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

1984 • 223 citations

Evidence for an adaptive DNA repair pathway in CHO and human skin fibroblast cell lines

1980 • 218 citations

Mismatch correction at O6-methylguanine residues in E. coli DNA

1982 • 215 citations

Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA

1975 • 193 citations

Mechanism of mutagenesis by O6-methylguanine

1984 • 191 citations

Purification and properties of O6-methylguanine-DNA transmethylase from rat liver.

1983 • 187 citations

Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines

1981 • 183 citations

<italic>Brief Communication:</italic> Carcinogenicity of N-Methyl-N-nitrosourea: Possible Role of Excision Repair of O<sup>6</sup>-Methylguanine From DNA

1974 • 182 citations

Repair of O6-methylguanine in adapted Escherichia coli.

1978 • 180 citations

Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.

1982 • 178 citations

Specific excision of methylation products from DNA of Escherichia coli treated with N-methyl-N′-nitro-N-nitrosoguanidine

1970 • 173 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Human tumor cell strains defective in the repair of alkylation damage

1980 • 169 citations

O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine.

1984 • 164 citations

Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

1984 • 162 citations

Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents

1979 • 160 citations

Quantitation of the adaptive response to alkylating agents

1979 • 145 citations

Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichiacoli

1980 • 141 citations

Repair of O⁶-methylguanine in DNA by demethylation is lacking in Mer⁻ human tumor cell strains

1983 • 140 citations

Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulphonate

1971 • 140 citations

O⁶-Alkylguanine-DNA alkyltransferase activity in human brain and brain tumors

1984 • 137 citations

A system in mouse liver for the repair of O⁶-methylguanine lesions in methylated DNA

1981 • 137 citations

Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O⁶-methyiguanine-DNA methyttransferase

1983 • 137 citations

Comparative Studies of the Hepatocarcinogen N,N-Dimethylnitrosamine in vivo: Reaction Sites in Rat Liver DNA and the Significance of their Relative Stabilities

1973 • 135 citations

Base-pairing properties of O6-methylguanine in template DNA during in vitro DNA replication.

1984 • 133 citations

Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas.

1984 • 127 citations

O6-Methylguanine-DNA methyltransferase of human lymphoid cells: structural and kinetic properties and absence in repair-deficient cells.

1983 • 125 citations

Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli

1983 • 110 citations

Inactivation and mutation of coliphage T2 by N-methyl- and N-ethyl-N-nitrosourea

1969 • 109 citations

Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine

1978 • 105 citations

A simplified assay for O⁶-methylguanine-DNA methyltransferase activity and its application to human neoplastic and non-neoplastic tissues

1984 • 104 citations

Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents

1982 • 103 citations

Interindividual variation in the activity of O⁶-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs

1983 • 102 citations

Removal of O6-methylguanine from DNA by human liver fractions.

1982 • 102 citations

Increased excision of O6-methylguanine from rat liver DNA after chronic administration of dimethylnitrosamine.

1979 • 101 citations

Inability of Chinese hamster ovary cells to excise O6-alkylguanine.

1980 • 98 citations

O6-alkylguanine-DNA alkyltransferase activity in normal human tissues and cells.

1984 • 98 citations

Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts.

1984 • 97 citations

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

1980 • 95 citations

Repair of O6-ethylguanine in DNA by a chromatin fraction from rat liver: transfer of the ethyl group to an acceptor protein.

1981 • 89 citations

DNA synthesis with methylated poly(dA-dT) templates: possible role of O⁴-methylthymine as a pro-mutagenic base

1977 • 88 citations

Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase.

1984 • 88 citations

Escherichia coli gene that controls sensitivity to alkylating agents

1978 • 88 citations

Evidence for removal at different rates of O-ethyl pyrimidines and ethylphosphotriesters in two human fibroblast cell lines

1979 • 86 citations

Enzymatic removal of O6-methylguanine from DNA by mammalian cell extracts

1978 • 83 citations

Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents.

1984 • 82 citations

Effect of partial hepatectomy on removal of O6-methylguanine from alkylated DNA by rat liver extracts

1981 • 81 citations

The stability of methylated purines and of methylphosphotriesters in the DNA of V79 cells after treatment with N-methyl-N-nitrosourea

1979 • 80 citations

Relative mutagenicity of antineoplastic drugs and other alkylating agents in V79 chinese hamster cells, independence of cytotoxic and mutagenic responses

1980 • 80 citations

Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone

1983 • 79 citations

A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA

1982 • 76 citations

Tissue-dependent enzyme-mediated repair or removal of O-ethyl pyrimidines and ethyl purines in carcinogen-treated rats

1981 • 74 citations

Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N′-nitro-N-nitrosoguanidine-damaged adenovirus 5

1979 • 74 citations

O6-methylguanine-DNA methyltransferase in wild-type and ada mutants of Escherichia coli

1982 • 70 citations

Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treatedhuman fibroblasts

1981 • 69 citations

HeLa cell variants that differ in sensitivity to monofunctional alkylating agents, with independence of cytotoxic and mutagenic responses

1979 • 65 citations

Adaptive response in mammalian cells: crossreactivity of different pretreatments on cytotoxicity as contrasted to mutagenicity.

1984 • 64 citations

Inducible repair of phosphotriesters in Escherichia coli.

1983 • 64 citations

Relationship of DNA repair phenotypes of human fibroblast and tumor strains to killing by N-methyl-N'-nitro-N-nitrosoguanidine.

1984 • 63 citations

Preparation and template activities of polynucleotides containing O2- and O4-alkyluridine.

1978 • 61 citations

Enhanced survival and reduced mutation and aberration frequencies induced in 79 Chinese hamster cells pre-exposed to low levels of methylating agents

1982 • 58 citations

O6-Methylguanine-DNA methyltransferase in human cells

1984 • 58 citations

Pretreatment with acetylaminofluorene enhances the repair of O6-methylguanine in DNA

1979 • 57 citations

The adaptive response of E. coli to low levels of alkylating agent: The role of polA in killing adaptation

1978 • 56 citations

Repair of premutagenic DNA lesions in human fetal tissues: evidence for low levels of O⁶-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activity in some tissues

1983 • 56 citations

Formation by diethylnitrosamine and persistence of O4-ethylthymidine in rat liver DNA in vivo

1980 • 55 citations

Stimulation of transfer of methyl groups from O⁶-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins

1981 • 54 citations

The prosthetic groups of animal amine oxidases

1966 • 51 citations

Adaptive response of Bacillus subtilis to N-methyl-N'-nitro-N-nitrosoguanidine

1983 • 50 citations

The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects

1980 • 49 citations

Cellular Responses to DNA Damage

1984 • 49 citations

Mechanism of action of the nitrosoureas—V

1983 • 49 citations

The stability of methyl and ethyl phosphotriesters in DNA in vivo

1977 • 46 citations

Regulation of O6-methylguanine-DNA methyltransferase levels in rat liver and kidney.

1983 • 46 citations

Adaptive resynthesis of O ⁶ -methylguanine-accepting protein can explain the differences between mammalian cells proficient and deficient in methyl excision repair

1982 • 45 citations

Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli

1984 • 44 citations

Genetic mapping of ada and adc mutations affecting the adaptive response of Escherichia coli to alkylating agents

1982 • 44 citations

Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents.

1981 • 43 citations

Lack of induction of O⁶-methylguanine-DNA methyltransferase in mammalian cells treated with N-methyl-N' -nitro-N-nitrosoguanidine

1984 • 43 citations

Enzymatic repair of O alkylated thymidine residues in DNA: Involvement of a O4-methylthymine-DNA methyltransferase and a O2-methylthymine DNA glycosylase

1984 • 40 citations

Quantitation of O6-methylguanine-DNA methyltransferase in HeLa cells

1983 • 40 citations

Comparison of repair of O⁶-methylguanine produced by N-methyl-N'-nitro-N-nitrosoguanidine in mouse and human cells

1984 • 38 citations

Repair and mutagenesis in Escherichia coli K-12 after exposure to various alkyl-nitrosoguanidines

1983 • 38 citations

O6-Methylguanine methyltransferase in rat liver

1983 • 38 citations

Adaptive increase of O⁶-methlguanine-acceptor protein in HeLa cells following N-methyl-N′-nitro-N-nitrosoguanidine treatment

1982 • 38 citations

A chromatin factor in rat liver which destroys O⁶‐ethylguanine in DNA

1980 • 36 citations

Dose response for DNA alkylation, [3H]thymidine uptake into DNA, and O6-methylguanine-DNA methyltransferase activity in hepatocytes of rats and mice continuously exposed to dimethylnitrosamine.

1984 • 35 citations

Pretreatment of Chinese hamster V79 cells with MNU increases survival without affecting DNA repair or mutagenicity

1981 • 34 citations

Role of the uvrE gene product and of inducible O-methylguanine removal in the induction of mutations by N-methyl-N′-nitro-N-nitrosoguanidine in Escherichia coli

1980 • 34 citations

Repair of O⁶‐methyl‐guanine residues in DNA takes place by a similar mechanism in extracts from hela cells, human liver, and rat liver

1982 • 33 citations

Limited capacity for the removal of O6-methylguanine and its regeneration in a human lymphoma line

1981 • 32 citations

Evidence for the involvement of lesions other than O⁶-alkylguanine in mammalian cell mutagenesis

1980 • 31 citations

Cross-resistance studies with V79 Chinese hamster cells adapted to the mutagenic or clastogenic effect of N-methyl-N′-nitro-N-nitrosoguanidine

1983 • 30 citations

Vertical distribution of mercury in sediments from the East Pacific Rise

1981 • 30 citations

Comparison of virus reactivation, DNA base damage, and cell cycle effects in autologous human melanoma cells resistant to methylating agents.

1984 • 28 citations

Untransformed xeroderma pigmentosum cells are not hypersensitive to sister-chromatid exchange production by ethyl methanesulphonate — implications for the use of transformed cell lines and for the mechanism by which SCE arise

1980 • 28 citations

An adaptive response to the cytotoxic effects of N-methyl-N-nitrosourea is apparently absent in normal human fibroblasts

1982 • 27 citations

Studies on adaptation of V79 Chinese hamster cells to low doses of methylating agents

1983 • 26 citations

Adaptive response to simple alkylating agents in Bacillus subtilis cells

1983 • 26 citations

Direct assay for O6-methylguanine-acceptor protein in cell extracts

1982 • 24 citations

Physiological modification of alkylating-agent induced mutagenesis. I. Effect of growth rate and repair capacity on nitrosomethylurea-induced mutation of Escherichia coli

1977 • 23 citations

Adaptive response orMicrococcus luteusto alkylating chemlcals

1984 • 23 citations

The formation and stability of methyl phosphotriesters in the DNA of rat tissues after treatment with the carcinogen N,N-dimethylnitrosamine

1977 • 23 citations

Nature of the constitutive and induced mammalian O6-methylguanine DNA repair enzyme

1982 • 23 citations

O⁶-Methylguanine-DNA transmethylase activity in extracts of human gastric mucosa

1984 • 22 citations

Enchancement of nitrosoguanidine mutagenesis by chloramphenicol in Escherichia coli K-12

1978 • 20 citations

DNA methylation by dimethylnitrosamine in the Mongolian gerbil (Meriones unguiculatus): indications of a deficient, noninducible hepatic repair system for O6-methylguanine.

1983 • 19 citations

Species differences in the inducibility of hepatic O6-alkylguanine repair in rodents

1982 • 19 citations

O6-Methylguanine removal by competent and incompetent human lymphoblastoid lines from the same male individual.

1983 • 18 citations

The Induction of Resistance to Alkylation Damage in Mammalian Cells

1983 • 15 citations

Cellular Response to DNA Damage

2007 • 15 citations

Relationship of methyl purines produced by MNNG in adenovirus 5 DNA to viral inactivation in repair-deficient (Mer−) human tumor cell strains

1984 • 14 citations

Kinetics of repair of O6-methylguanine in DNA by O6-methylguanine-DNA methyltransferase in, vitro and in, vivo

1982 • 14 citations

Regulation of the capacity for O6-methylguanine removal from DNA in human lymphoblastoid cells studied by cell hybridization.

1982 • 14 citations

The capacity of rat hepatoma cell lines for O⁶-methylguanine-DNA repair correlates with their status of differentiation

1984 • 14 citations

Comparison of mutagenicity of N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea in human diploid fibroblasts

1983 • 12 citations

Mutation induction in Chinese hamster ovary cells after chronic pretreatment with MNNG

1983 • 12 citations

MNNG-pretreatment of a human kidney carcinoma cell strain decreases its ability to repair MNNG-treated adenovirus 5

1981 • 11 citations

Hybrids between human tumor cell strains differing in repair of MNNG-produced DNA damage

1984 • 10 citations

A search for adaptive or inducible responses to DNA damage in V79 Chinese hamster cells

1982 • 8 citations

Repair of O⁶‐ethylguanine DNA lesions in isolated cell nuclei

1983 • 8 citations

Properties of the chromatin repair activity against O⁶‐ethylguanine lesions in DNA

1983 • 3 citations