Purification and properties of O6-methylguanine-DNA transmethylase from rat liver.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Minimization of variation in the response to different proteins of the Coomassie blue G dye-binding assay for protein

1981 • 1,422 citations

DNA Repair Enzymes

1982 • 905 citations

DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair

1979 • 562 citations

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

1974 • 495 citations

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase

1977 • 336 citations

Formation and Metabolism of Alkylated Nucleosides: Possible Role in Carcinogenesis by Nitroso Compounds and Alkylating Agents

1977 • 304 citations

Chemical carcinogens and DNA

1979 • 288 citations

Some chemical aspects of dose-response relationships in alkylation mutagenesis

1974 • 284 citations

N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.

1979 • 276 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

Carcinogenesis: Fundamental Mechanisms and Environmental Effects

1980 • 231 citations

Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA

1975 • 193 citations

Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichiacoli

1980 • 141 citations

A system in mouse liver for the repair of O⁶-methylguanine lesions in methylated DNA

1981 • 137 citations

Molecular and Cellular Mechanisms of Mutagenesis

1982 • 118 citations

Immunological quantification by high-affinity antibodies of O6-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea.

1980 • 112 citations

Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine

1978 • 105 citations

Removal of O6-methylguanine from DNA by human liver fractions.

1982 • 102 citations

Effect of chronic treatment of rats with dimethylnitrosamine on the removal of O6-methylguanine from DNA.

1980 • 99 citations

Alkylation of Rat Liver DNA by Dimethylnitrosamine: Effect of Dosage on O 6 -Methylguanine Levels 2

1977 • 93 citations

Repair of O6-ethylguanine in DNA by a chromatin fraction from rat liver: transfer of the ethyl group to an acceptor protein.

1981 • 89 citations

Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen.

1982 • 84 citations

Enzymatic removal of O6-methylguanine from DNA by mammalian cell extracts

1978 • 83 citations

A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA

1982 • 76 citations

The Inducible Repair of Alkylated DNA

1981 • 70 citations

O6-methylguanine-DNA methyltransferase in wild-type and ada mutants of Escherichia coli

1982 • 70 citations

Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treatedhuman fibroblasts

1981 • 69 citations

Specificity of mammalian spermidine synthase and spermine synthase

1981 • 62 citations

Dimethylnitrosamine inhibits enzymatic removal of O6-methylguanine from DNA

1978 • 62 citations

Stimulation of transfer of methyl groups from O⁶-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins

1981 • 54 citations

Methylation of nuclear proteins by dimethylnitrosamine and by methionine in the rat in vivo

1971 • 53 citations

Formation and loss of alkylated purines from DNA of hamster liver after administration of dimethylnitrosamine.

1979 • 53 citations

Formation and subsequent excision of O6-ethylguanine from DNA of rat liver following administration of diethylnitrosamine.

1979 • 44 citations

Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents.

1981 • 43 citations

Mode of action of methylating carcinogens: comparative studies of murine and human cells

1981 • 37 citations

A chromatin factor in rat liver which destroys O⁶‐ethylguanine in DNA

1980 • 36 citations

REACTION OF THE CARCINOGEN DIMETHYLNITROSAMINE WITH PROTEINS AND WITH THIOL COMPOUNDS IN THE INTACT ANIMAL

1965 • 36 citations

Limited capacity for the removal of O6-methylguanine and its regeneration in a human lymphoma line

1981 • 32 citations

Repair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1

1981 • 25 citations

Formation and Subsequent Repair of Alkylation Lesions in Tissues of Rodents Treated with Nitrosamines

1980 • 24 citations

Effect of pretreatment by feeding acetylaminofluorene on methylated purines formed in rat liver DNA after administration of dimethylnitrosamine

1981 • 23 citations

Effect of pretreatment of rats with N-methyl-N-nitrosourea on the repair of O⁶-methylguanine in liver DNA

1981 • 22 citations

Metabolism of O6-alkyldeoxyguanosines and their effect on removal of O6-methylguanine from rat liver DNA

1979 • 21 citations

Chronic or acute administration of various dialkylnitrosamines enhances the removal of O6-methylguanine from rat liver DNA in vivo

1982 • 19 citations

Alkylation of DNA and carcinogenicity ofN‐nitroso compounds

1980 • 16 citations