Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

1970 • 500 citations

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

1974 • 495 citations

Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens.

1974 • 439 citations

All oxygens in nucleic acids react with carcinogenic ethylating agents

1976 • 311 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay

1978 • 206 citations

Repair of O6-methylguanine in adapted Escherichia coli.

1978 • 180 citations

Human tumor cell strains defective in the repair of alkylation damage

1980 • 169 citations

Repair of DNA damaged by alkylating carcinogens is defective in xeroderma pigmentosum-derived fibroblasts

1977 • 109 citations

Evidence for removal at different rates of O-ethyl pyrimidines and ethylphosphotriesters in two human fibroblast cell lines

1979 • 86 citations

Enzymatic removal of O6-methylguanine from DNA by mammalian cell extracts

1978 • 83 citations

The measurement of chemically-induced DNA repair synthesis in human cells by BND-Cellulose chromatography

1975 • 81 citations

Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N′-nitro-N-nitrosoguanidine-damaged adenovirus 5

1979 • 74 citations

The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects

1980 • 49 citations

Selectivity of the excision of alkylation products in a xeroderma pigmentosum-derived lymphoblastoid line

1979 • 42 citations

Role of the uvrE gene product and of inducible O-methylguanine removal in the induction of mutations by N-methyl-N′-nitro-N-nitrosoguanidine in Escherichia coli

1980 • 34 citations

Untransformed xeroderma pigmentosum cells are not hypersensitive to sister-chromatid exchange production by ethyl methanesulphonate — implications for the use of transformed cell lines and for the mechanism by which SCE arise

1980 • 28 citations

Differences in the ability of human lymphoblastoid lines to exclude bromodeoxyuridine and in their sensitivity to methyl methanesulfonate and to incorporated [3H]thymidine.

1979 • 7 citations