O6-Methylguanine-DNA methyltransferase of human lymphoid cells: structural and kinetic properties and absence in repair-deficient cells.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

The Estimation of Polypeptide Chain Molecular Weights by Gel Filtration in 6 M Guanidine Hydrochloride

1969 • 603 citations

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

1974 • 495 citations

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents

1982 • 287 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification

1980 • 234 citations

Purification and properties of O6-methylguanine-DNA transmethylase from rat liver.

1983 • 187 citations

Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines

1981 • 183 citations

Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.

1982 • 178 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents

1979 • 160 citations

Quantitation of the adaptive response to alkylating agents

1979 • 145 citations

Enzymatic release of 7-methylguanine from methylated DNA by rodent liver extracts.

1981 • 142 citations

Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichiacoli

1980 • 141 citations

A system in mouse liver for the repair of O⁶-methylguanine lesions in methylated DNA

1981 • 137 citations

Human lymphoblasts contain DNA glycosylase activity excising N-3 and N-7 methyl and ethyl purines but not O6-alkylguanines or 1-alkyladenines.

1981 • 121 citations

Uracil DNA-glycosylase. Purification and properties of this enzyme isolated from blast cells of acute myelocytic leukemia patients.

1980 • 112 citations

Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents

1982 • 103 citations

Removal of O6-methylguanine from DNA by human liver fractions.

1982 • 102 citations

Effect of chronic treatment of rats with dimethylnitrosamine on the removal of O6-methylguanine from DNA.

1980 • 99 citations

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

1980 • 95 citations

Repair of O6-ethylguanine in DNA by a chromatin fraction from rat liver: transfer of the ethyl group to an acceptor protein.

1981 • 89 citations

Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen.

1982 • 84 citations

A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA

1982 • 76 citations

The Inducible Repair of Alkylated DNA

1981 • 70 citations

O6-methylguanine-DNA methyltransferase in wild-type and ada mutants of Escherichia coli

1982 • 70 citations

Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treatedhuman fibroblasts

1981 • 69 citations

HeLa cell variants that differ in sensitivity to monofunctional alkylating agents, with independence of cytotoxic and mutagenic responses

1979 • 65 citations

Enzymic excision of 3-methyladenine and 7-methylguanine by a rat liver nuclear fraction

1981 • 58 citations

Stimulation of transfer of methyl groups from O⁶-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins

1981 • 54 citations

Partial purification and characterization of a human 3-methyladenine-DNA glycosylase

1979 • 54 citations

Adaptive resynthesis of O ⁶ -methylguanine-accepting protein can explain the differences between mammalian cells proficient and deficient in methyl excision repair

1982 • 45 citations

Genetic mapping of ada and adc mutations affecting the adaptive response of Escherichia coli to alkylating agents

1982 • 44 citations

Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents.

1981 • 43 citations

Quantitation of O6-methylguanine-DNA methyltransferase in HeLa cells

1983 • 40 citations

Mode of action of methylating carcinogens: comparative studies of murine and human cells

1981 • 37 citations

Resistance of Salmonella typhimurium TA 1535 to O⁶-guanine methylation and mutagenesis induced by low doses of N-methyl-N'-nitro-N-nitrosoguanidine: an apparent constitutive repair activity

1982 • 34 citations

Limited capacity for the removal of O6-methylguanine and its regeneration in a human lymphoma line

1981 • 32 citations

Extracts of chronic lymphocytic leukemia lymphocytes have a high level of DNA repair activity fo O6-methylguanine.

1982 • 29 citations

An adaptive response to the cytotoxic effects of N-methyl-N-nitrosourea is apparently absent in normal human fibroblasts

1982 • 27 citations

Species differences in the inducibility of hepatic O6-alkylguanine repair in rodents

1982 • 19 citations

Regulation of the capacity for O6-methylguanine removal from DNA in human lymphoblastoid cells studied by cell hybridization.

1982 • 14 citations

Excision of O⁶-methylguanine from DNA by human fibroblasts determined by a sensitive competition method

1982 • 13 citations

Cellular aspects of DNA repair.

1983 • 1 citations