Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

Experiments in molecular genetics

1972 • 28,260 citations

Tissue sulfhydryl groups

1959 • 25,130 citations

The Role of Glutathione and Glutathione S-Transferases in the Metabolism of Chemical Carcinogens and Other Electrophilic Agents

1979 • 1,179 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

1970 • 500 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

An adaptive response of E. coli to low levels of alkylating agent: Comparison with previously characterised DNA repair pathways

1977 • 225 citations

Repair of O6-methylguanine in adapted Escherichia coli.

1978 • 180 citations

Isolation and initial characterization of glutathione-deficient mutants of Escherichia coli K 12

1975 • 173 citations

Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents

1979 • 160 citations

Quantitation of the adaptive response to alkylating agents

1979 • 145 citations

THE FREQUENCY DISTRIBUTION OF SPONTANEOUS BACTERIOPHAGE MUTANTS AS EVIDENCE FOR THE EXPONENTIAL RATE OF PHAGE REPRODUCTION

1951 • 124 citations

Diazomethane as the active agent in nitrosoguanidine mutagenesis and lethality

1968 • 107 citations

Glutathione biosynthesis in Escherichia coli K 12 properties of the enzymes and regulation

1975 • 98 citations

Pathways of mutagenesis and repair in Escherichia coli exposed to low levels of simple alkylating agents

1978 • 95 citations

Reactions of cysteine with N-methyl-N-nitroso-p-toluenesulfonamide and N-methyl-N′-nitro-N-nitrosoguanidine

1969 • 91 citations

The Inducible Repair of Alkylated DNA

1981 • 70 citations

Comparison of the effects of cysteine upon the decomposition of nitrosoureas and of 1-methyl-3-nitro-1-nitrosoguanidine

1972 • 35 citations

Studies on mechanisms for the maintenance of constant mutability: mutability and the resistance to mutagens.

1966 • 29 citations

RESISTANCE AND CROSS-RESISTANCE OF ESCHERICHIA COLI MUTANTS TO ANTICANCER AGENTS. 1-METHYL-3-NITRO-1-NITROSOGUANIDINE

1961 • 22 citations